IP Library › Granted Patent US 12,324,927
Granted Patent B2
US 12,324,927 · App. 17/291,703 · Granted Jun 10, 2025

Methods and systems for photodynamic therapy calculations

Inventors: Timothy C. Zhu (Glen Mills, PA); Arjun G. Yodh (Merion, PA)
Assignee: The Trustees of the University of Pennsylvania
A61N5/062A61B5/0261A61B5/1459A61B5/4836A61B5/6852A61N5/0603A61B2562/0233A61B2562/228A61N2005/0628A61N2005/063
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Quick Facts
Patent No.
US 12,324,927
App. No.
17/291,703
Granted
Jun 10, 2025
Kind
B2
Abstract

Methods and systems are described for implementing a photodynamic therapy. An example method may comprise determining, during photodynamic therapy and using a plurality of optical probes spatially distributed within a patient, data indicative of one or more of a photodynamic therapy dosage, a fluence rate of a photodynamic therapy treatment light, or a reactive oxygen species concentration associated with corresponding locations of the plurality of optical probes. The example method may comprise changing, based on the data, one or more treatment parameters associated with providing a photodynamic therapy.

Claims (52)

1. A method, comprising:

determining, during photodynamic therapy and using a plurality of optical probes spatially distributed within a patient, data indicative of a reactive oxygen species concentration associated with corresponding locations of the plurality of optical probes; and

changing, based on the data, one or more treatment parameters associated with providing a photodynamic therapy.

2. The method of claim 1 , further comprises determining, during the photodynamic therapy and using the plurality of optical probes spatially distributed within the patient, one or more of data indicative of a photodynamic therapy dosage or data indicative of a fluence rate of a photodynamic therapy treatment light.

3. The method of claim 2 , wherein one or more of the data indicative of the photodynamic therapy dosage, the data indicative of the fluence rate of the photodynamic therapy treatment light, or the data indicative of the reactive oxygen species concentration are determined in parallel.

4. The method of claim 1 , wherein the one or more treatment parameters comprise one or more of an intensity of the photodynamic therapy treatment light, a location of the photodynamic therapy treatment light, or a duration of photodynamic therapy treatment light.

5. The method of claim 1 , further comprising:

causing, during the photodynamic therapy and using the plurality of optical probes spatially distributed within the patient, emission of light; and

determining, based on optical signals received via the plurality of optical probes and for one or more corresponding locations, data indicative of one or more of an oxygen level or a blood flow rate associated with the corresponding location,

wherein the reactive oxygen species concentration is determined based on the data indicative of one or more of the oxygen level or the blood flow rate associated with the corresponding location.

6. The method of claim 1 , wherein one of more of the plurality of optical probes comprises a blood flow sensor comprising a first optical fiber configured to emit a light and one or more second optical fibers configured to receive a reflection of the emitted light.

7. The method of claim 6 , wherein the one or more second optical fibers comprise a third optical fiber for receiving the reflection and a fourth optical fiber for receiving the reflection, wherein the third optical fiber has a different length than the fourth optical fiber.

8. The method of claim 1 , wherein the plurality of optical probes comprise a photodynamic therapy dosage sensor comprising a fifth optical fiber.

9. A system, comprising:

a plurality of optical probes configured to be disposed at one or more locations of a patient, the plurality of optical probes each comprising:

a first optical fiber configured to emit light at a corresponding location of the one or more locations;

one or more second optical fibers configured to receive a reflection of the emitted light; and

at least one processor configured to:

determine, based on optical signals received via the one or more second optical fibers and for one or more corresponding locations, data indicative of one or more of an oxygen level or a blood flow rate associated with the corresponding location;

determine, based on the data indicative of one or more of the oxygen level or the blood flow rate, a reactive oxygen species concentration associated with the corresponding location; and

output the reactive oxygen species concentration associated with the corresponding location.

10. The system of claim 9 , wherein the plurality of optical probes comprise a third optical fiber that is bifurcated into a fourth optical fiber and a fifth optical fiber.

11. The system of claim 10 , further comprising:

one or more spectrometers optically coupled to the plurality of optical probes via corresponding fourth optical fibers, wherein each of the plurality of optical probes is coupled to a different channel of the one or more spectrometers, wherein the one or more spectrometers are configured to generate spectral data based on optical signals from the plurality of optical probes.

12. The system of claim 11 , wherein the at least one processor is further configured to:

determine, based on the spectral data, data indicative of a photodynamic therapy dosage associated with a corresponding location;

determine, based on optical signals from one or more of the second optical fibers, data indicative of a fluence rate of a photodynamic therapy treatment light associated with a corresponding location; and

output, during a photodynamic therapy treatment, one or more of the data indicative of the photodynamic therapy dosage or the data indicative of the fluence rate for a corresponding location.

13. The system of claim 10 , wherein the first optical fiber, the one or more second optical fibers, and the third optical fiber are integrated as a single probe.

14. The system of claim 9 , wherein the data indicative of the blood flow rate comprises a blood flow index.

15. A method, comprising:

causing, during photodynamic therapy and using a plurality of optical probes spatially distributed within a patient, emission of light;

determining, based on optical signals received via the plurality of optical probes and for one or more corresponding locations, data indicative of one or more of an oxygen level or a blood flow rate associated with the corresponding location;

determining, based on the data indicative of one or more of the oxygen level or the blood flow rate, a reactive oxygen species concentration associated with the corresponding location; and

outputting the reactive oxygen species concentration associated with the corresponding location.

16. The method of claim 15 , further comprising determining, during the photodynamic therapy and using the plurality of optical probes spatially distributed within the patient, data indicative of one or more of a photodynamic therapy dosage or a fluence rate of a photodynamic therapy treatment light associated with corresponding locations of the plurality of optical probes.

17. The method of claim 16 , further comprising outputting, during the photodynamic therapy, the data indicative of one or more of the photodynamic therapy dosage or the fluence rate of the photodynamic therapy treatment light.

18. The method of claim 15 , further comprising changing, based on the data, one or more treatment parameters associated with providing the photodynamic therapy.

19. The method of claim 15 , further comprising determining the data indicative of one or more of the oxygen level or the blood flow rate associated with the corresponding location comprise determining data indicative of a blood flow index.

20. The method of claim 15 , wherein determining the data indicative of one or more of the oxygen level or the blood flow rate associated with the corresponding location comprises determining data indicative of the blood flow using a one or more of a diffuse correlation spectroscopy system or a diffuse optical spectroscopy system.

21. A method comprising:

determining, during photodynamic therapy and using a plurality of optical probes spatially distributed within a patient, data indicative of one or more of a photodynamic therapy dosage, a fluence rate of a photodynamic therapy treatment light, or a reactive oxygen species concentration associated with corresponding locations of the plurality of optical probes; and

changing, based on the data, one or more treatment parameters associated with providing a photodynamic therapy.

22. The method of claim 21 , wherein the one or more treatment parameters comprise one or more of an intensity of the photodynamic therapy treatment light, a location of the photodynamic therapy treatment light, or a duration of photodynamic therapy treatment light.

23. The method of claim 21 , wherein one or more of the data indicative of the photodynamic therapy dosage, the data indicative of the fluence rate of the photodynamic therapy treatment light, or the data indicative of the reactive oxygen species concentration are determined in parallel.

24. An integrated probe comprising:

a photodynamic therapy dosage sensor comprising a first optical fiber that is bifurcated into a second optical fiber and a third optical fiber; and

a blood flow sensor comprising a fourth optical fiber configured to emit a light and one or more fifth optical fibers configured to receive a reflection of the emitted light.

25. The integrated probe of claim 24 , wherein the integrated probe is configured to be coupled to a device configured to one or more of:

determine, based on optical signals from the second optical fiber, data indicative of photodynamic therapy dosage associated with a location of the integrated probe,

determine, based on optical signals from the third optical fiber, data indicative of a fluence rate of a photodynamic therapy treatment light associated with location, or

determine, based on optical signals from one or more fifth optical fibers, a reactive oxygen species concentration associated with the location.

Assignments (2)
CONFIRMATORY LICENSE Recorded Dec 5, 2023
From: UNIVERSITY OF PENNSYLVANIA
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 065774/0328 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 6, 2021
From: ZHU, TIMOTHY C.; YODH, ARJUN G.
To: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Reel/Frame 056155/0400 →
Continuity (2)
Provisional Application 62756380 · Nov 6, 2018
Related Publication 20220001193A1 · Jan 6, 2022
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