Thermally controlled reconfigurable medical devices
Systems and methods related to reconfigurable medical devices are described. In some embodiments, a reconfigurable medical device may include a central core and a plurality of arms. The arms may be rotatably coupled to the central core such that the plurality of arms may rotate outwards away from the central core to selectively reconfigure the reconfigurable device between a retracted configuration and an expanded configuration. In an initial state, the arms may be biased outwards away from the central core into the expanded configuration. When the reconfigurable device is exposed to a temperature greater than a threshold temperature, the arms may be biased towards the central core into the retracted configuration. In some embodiments, a reconfigurable medical device may include therapeutic compound-loaded needles coupled to distal portions of the arms.
1. A reconfigurable medical device comprising:
a central core; and
a plurality of arms rotatably coupled to the central core such that the plurality of arms are configured to rotate outwards away from the central core to selectively reconfigure the reconfigurable device between a first retracted configuration and a second expanded configuration, wherein in an initial state each arm of the plurality of arms is biased outwards away from the central core into the second expanded configuration, wherein when the reconfigurable device is exposed to a temperature greater than a threshold temperature, each arm of the plurality of arms is biased towards the central core into the first retracted configuration, and wherein, in the first retracted configuration, a longitudinal axis of each arm of the plurality of arms is parallel to a longitudinal axis of the central core and, in the second expanded configuration, the longitudinal axis of each arm of the plurality of arms is perpendicular to the longitudinal axis of the central core.
2. The reconfigurable medical device of claim 1 , further comprising a plurality of therapeutic compound-loaded needles coupled to distal portions of the plurality of arms.
3. The reconfigurable medical device of claim 1 , wherein each arm of the plurality of arms is biased towards the central core by a shape memory component.
4. The reconfigurable medical device of claim 3 , wherein each arm of the plurality of arms is connected to an elastic component that uses stored elastic energy to bias the reconfigurable medical device into the second expanded configuration.
5. The reconfigurable medical device of claim 3 , wherein the shape memory component includes a shape memory spring.
6. The reconfigurable medical device of claim 3 , wherein the shape memory component comprises one or more selected from the group of a shape memory alloy and a shape memory polymer.
7. The reconfigurable medical device of claim 1 , further comprising a dissolvable capsule at least partially surrounding the central core and the plurality of arms, wherein the dissolvable capsule retains the plurality of arms in the first retracted configuration.
8. The reconfigurable medical device of claim 1 , wherein the threshold temperature is greater than normothermia.
9. The reconfigurable medical device of claim 1 , wherein a maximum transverse dimension of the reconfigurable medical device in the first retracted configuration is less than 18 mm.
10. The reconfigurable medical device of claim 1 , wherein a maximum transverse dimension of the reconfigurable medical device in the second expanded configuration is greater than or equal to 20 mm and less than or equal to 40 mm.
11. The reconfigurable medical device of claim 1 , wherein the reconfigurable medical device is configured to be deployed in an esophagus of a subject.
12. The reconfigurable medical device of claim 1 , wherein each arm is configured to rotate about a respective rotational axis located outwardly from an outer perimeter of the central core.