Granted Patent B2

US 12,653,992 · App. 17/295,277 · Granted Jun 16, 2026

Inventors: Jeffrey A. Shimizu (Poway, CA); Mitchell Lawrence Jones (La Jolla, CA); Mark Sasha Drlik (Victoria, CA); Iman Niknia (Victoria, CA); Nathan John Muller (Victoria, CA); Tuyen Nguyen (Victoria, CA); Christopher Loren Wahl (San Diego, CA); Edward Mudge (Cambridgeshire, GB); Nicholas Mark Salt (Cambridgeshire, GB); Nia Eleri Stevens (Cambridgeshire, GB); Stuart Robert Abercrombie (Cambridgeshire, GB); Christopher Ian Bunce (Cambridgeshire, GB); Nelson Quintana (Temecula, CA)

Assignee: BT Bidco, Inc.

A61M31/002A61K38/1796A61K38/26A61K38/28A61M11/02A61P1/04C07K16/241A61M2210/1042A61M2210/106A61M2210/1064

Abstract

Claims (31)

1 . An ingestible device comprising:

a storage reservoir in a housing;

a dispensable substance in the storage reservoir;

one or more nozzles in the housing connecting into the storage reservoir, each nozzle extending through a curved sidewall of the housing;

a gas container in the housing containing a compressed gas providing an internal pressure of about 280 psig to about 390 psig; and

a piercer for piercing the gas container to release the compressed gas from the gas container the piercer exerting a force on an enteric material triggering component, the enteric material triggering component resisting the force until the device is triggered, releasing the compressed gas from the gas container after the ingestible device is ingested;

wherein the released compressed gas drives the dispensable substance into the submucosa of the gastrointestinal tract of a patient.

2 . The ingestible device of claim 1 wherein the ingestible device is configured to deliver the dispensable substance as a jet through each nozzle with a peak jet power of each jet of about one Watt to about three Watts.

3 . The ingestible device of claim 1 wherein the released compressed gas drives a sliding piston in the housing between the gas container and the storage reservoir.

4 . The ingestible device of claim 1 wherein the ingestible device is configured to provide a peak fluid pressure on the dispensable substance of about 300 psig to about 375 psig.

5 . The ingestible device of claim 1 wherein the ingestible device is configured to deliver the dispensable substance at a mean jet velocity of from about 20 m/s to about 50 m/s.

6 . The ingestible device of claim 1 wherein the ingestible device is configured to deliver the dispensable substance to tissue of the gastrointestinal tract of a patient at a peak jet force of about 0.09 N to about 0.15 N.

7 . The ingestible device of claim 1 wherein the device is configured to release a dispensable substance volume of 50 microliters to 500 microliters.

8 . The ingestible device of claim 1 wherein one or more of the nozzles has a nozzle diameter of 0.25 millimeters to 0.45 millimeters.

9 . The ingestible device of claim 1 wherein the device is configured to release a dispensable substance volume of 200 microliters to 400 microliters.

10 . An ingestible device comprising:

a storage reservoir in a housing;

a dispensable substance in the storage reservoir;

one or more nozzles connecting into the storage reservoir, each nozzle extending through a sidewall of the housing;

a gas container in the housing containing a compressed gas, the gas container configured to provide an internal pressure of about 280 psig to about 390 psig;

a sliding piston in the housing between the gas container and the storage reservoir; and

an enteric material triggering component which triggers release of the compressed gas from the gas container after the ingestible device is ingested;

wherein the internal pressure is configured to deliver the dispensable substance into the submucosa of the gastrointestinal tract of a patient.

11 . The ingestible device of claim 10 wherein the ingestible device is configured to deliver the dispensable substance as a jet through each nozzle with a peak jet power of each jet of about one Watt to about three Watts.

12 . The ingestible device of claim 10 wherein the ingestible device is configured to provide a peak fluid pressure on the dispensable substance of about 300 psig to about 375 psig.

13 . The ingestible device of claim 10 wherein the ingestible device is configured to deliver the dispensable substance at a mean jet velocity of from about 20 m/s to about 50 m/s.

14 . The ingestible device of claim 10 wherein the ingestible device is configured to deliver the dispensable substance to tissue of the gastrointestinal tract of a patient at a peak jet force of about 0.09 N to about 0.15 N.

15 . The ingestible device of claim 10 wherein the device is configured to release a dispensable substance volume of 50 microliters to 500 microliters.

16 . The ingestible device of claim 10 wherein one or more of the nozzles has a nozzle diameter of 0.25 millimeters to 0.45 millimeters.

17 . The ingestible device of claim 10 wherein the nozzles extend through a cylindrical sidewall of the housing.

18 . The ingestible device of claim 10 wherein the enteric material triggering component exerts a restraining force which prevents release of compressed gas from the gas container until it is at least partially dissolved, degraded and/or eroded after the device is ingested.

Assignments (7)

Continuity (5)

References Cited (137)