IP Library › Granted Patent US 12,311,044
Granted Patent B2
US 12,311,044 · App. 17/296,568 · Granted May 27, 2025

Antimicrobial composition

Inventors: Renu Kapoor (Bangalore, IN); Srikala Kumaran (Bangalore, IN); Mruthyunjaya Swamy Mathapathi (Bangalore, IN); Amitabha Majumdar (Bangalore, IN)
Assignee: Conopco, Inc.
A61K8/41A61K8/347A61K8/4926A61Q17/005A61Q19/10
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,311,044
App. No.
17/296,568
Granted
May 27, 2025
Kind
B2
Abstract

The present invention relates to an antimicrobial composition. More particularly the present invention relates to an antimicrobial composition for malodor and oral biofilm inhibitions benefits. Accordingly, the present invention provides an antimicrobial composition comprising: a. 0.1 to 10% by weight of tetrahydroxypropyl ethylenediamine (THPE) and, b. 0.001 to 10% by weight of at least one compound selected from a biphenol.

Claims (15)

1. An antimicrobial composition comprising;

a. 0.1 to 10% by weight of tetrahydroxypropyl ethylenediamine (THPE); and,

b. 0.001 to 10% by weight of at least one compound selected from a biphenol.

2. The antimicrobial composition as claimed in claim 1 , wherein the biphenol comprises di-allyl substitution.

3. The antimicrobial composition as claimed in claim 2 , wherein the di-allyl substitution is at the position 3-5′ or 5-5′ of the biphenol.

4. The antimicrobial composition as claimed in claim 3 , wherein the biphenol is selected from honokiol and magnolol.

5. The antimicrobial composition as claimed in claim 1 , additionally comprising niacinamide or its derivatives selected from picolinamide, isonicotinamide, N-cyclopropyl nicotinamide, and N-cyclopentyl nicotinamide.

6. The antimicrobial composition as claimed in claim 5 , wherein the amount of niacinamide or its derivatives is in the range of 0.1 to 10% by weight.

7. The antimicrobial composition as claimed in claim 1 , further comprising a cosmetically accepted base.

8. The antimicrobial composition as claimed in claim 1 , wherein the composition is in the form of a leave-on composition.

9. The antimicrobial composition as claimed in claim 1 , wherein the composition is in the form of a wash-off composition.

10. The antimicrobial composition as claimed in claim 8 , wherein said leave-on composition includes lotion, cream, deodorants, hand sanitizer and body spray.

11. A method of disinfecting a surface comprising the step of applying on to the surface the antimicrobial composition as claimed in claim 1 .

12. The method as claimed in claim 11 , wherein the composition is in the form of a wash-off composition and wherein the method comprises an additional step of at least partially removing the composition.

13. A method of obtaining an antimicrobial benefit, comprising applying the antimicrobial composition of claim 1 to a surface, wherein after application of the antimicrobial composition, residual microbes on the surface are less than before application.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 25, 2021
From: KAPOOR, RENU; KUMARAN, SRIKALA; MATHAPATHI, MRUTHYUNJAYA SWAMY; MAJUMDAR, AMITABHA
To: CONOPCO, INC., D/B/A UNILEVER
Reel/Frame 056338/0098 →
Priority Claims (1)
EP 18213528 · Dec 18, 2018 · regional
Continuity (1)
Related Publication 20220087914A1 · Mar 24, 2022
References Cited (164)
US 3050467A · Horowtiz et al. · 1962 [cited by applicant]
US 3907745A · Bsharah et al. · 1975 [cited by applicant]
US 4585597A · Lang et al. · 1986 [cited by applicant]
US 5532290A · Newington et al. · 1996 [cited by applicant]
US 6080391A · Tsuchiya et al. · 2000 [cited by applicant]
US 6632422B2 · Burry et al. · 2003 [cited by applicant]
US 7347985B2 · Maxwell et al. · 2008 [cited by applicant]
US 8071077B2 · Subramanyam et al. · 2011 [cited by applicant]
US 9000231B2 · Naik et al. · 2015 [cited by applicant]
US 9426981B2 · Hurtmanns · 2016 [cited by examiner]
US 10130093B2 · Macinga et al. · 2018 [cited by applicant]
US 10251392B2 · Karandikar et al. · 2019 [cited by applicant]
US 20030161798A1 · Kellner et al. · 2003 [cited by applicant]
US 20040116551A1 · Terry · 2004 [cited by applicant]
US 20060047005A1 · Salamone · 2006 [cited by applicant]
US 20060134020A1 · Robinson et al. · 2006 [cited by applicant]
US 20060134024A1 · Trivedi et al. · 2006 [cited by applicant]
US 20060264497A1 · Zeligs · 2006 [cited by applicant]
US 20060275222A1 · James Dodds et al. · 2006 [cited by applicant]
US 20070281999A1 · Fox et al. · 2007 [cited by applicant]
US 20080000498A1 · Lestage et al. · 2008 [cited by applicant]
US 20080014247A1 · Lu et al. · 2008 [cited by applicant]
US 20080226582A1 · Park et al. · 2008 [cited by applicant]
US 20080260869A1 · Faller et al. · 2008 [cited by applicant]
US 20090156551A1 · Kilpert et al. · 2009 [cited by applicant]
US 20100120911A1 · Majeed et al. · 2010 [cited by applicant]
US 20110129426A1 · Tian et al. · 2011 [cited by applicant]
US 20110150949A1 · Gonzales et al. · 2011 [cited by applicant]
US 20120020896A1 · Trivedi et al. · 2012 [cited by applicant]
US 20120208894A1 · Kampf · 2012 [cited by applicant]
US 20120251464A1 · Subramanyam et al. · 2012 [cited by applicant]
US 20120288548A1 · Boyd et al. · 2012 [cited by applicant]
US 20130183394A1 · Wuttke · 2013 [cited by applicant]
US 20140234232A1 · Subramanyam et al. · 2014 [cited by applicant]
US 20140328772A1 · Hourigan · 2014 [cited by applicant]
US 20150079141A1 · Wingfield · 2015 [cited by applicant]
US 20150157542A1 · Schaeffer · 2015 [cited by applicant]
US 20170044313A1 · Youssef · 2017 [cited by applicant]
US 20170080197A1 · Paunescu et al. · 2017 [cited by applicant]
US 20170113989A1 · Jaracz et al. · 2017 [cited by applicant]
US 20170173162A1 · Jiao et al. · 2017 [cited by applicant]
US 20190117569A1 · Epps et al. · 2019 [cited by applicant]
US 20200330408A1 · Appavoo et al. · 2020 [cited by applicant]
CN 1331968 · 2002 [cited by applicant]
CN 101002798 · 2007 [cited by applicant]
CN 101279901 · 2008 [cited by applicant]
CN 101804043 · 2010 [cited by applicant]
CN 102743363 · 2011 [cited by applicant]
CN 102716188 · 2012 [cited by applicant]
CN 102871989 · 2013 [cited by applicant]
CN 103045400 · 2013 [cited by applicant]
CN 104920489 · 2015 [cited by applicant]
CN 105198712 · 2015 [cited by applicant]
CN 105997659 · 2016 [cited by applicant]
CN 106358648 · 2017 [cited by applicant]
CN 106924120 · 2017 [cited by applicant]
CN 109771312 · 2023 [cited by applicant]
DE 202004006865 · 2004 [cited by applicant]
DE 102007028508 · 2008 [cited by applicant]
DE 202010006005 · 2010 [cited by applicant]
DE 102010015788 · 2011 [cited by applicant]
EP 2272339 · 2011 [cited by applicant]
EP 2589374 · 2013 [cited by applicant]
EP 2589375 · 2013 [cited by applicant]
EP 3246022 · 2017 [cited by applicant]
JP 2007161651 · 2007 [cited by applicant]
JP 2008247775 · 2008 [cited by applicant]
JP 2011111444 · 2011 [cited by applicant]
KR 20150041981 · 2015 [cited by applicant]
WO WO0001353 · 2000 [cited by applicant]
WO WO0047184 · 2000 [cited by applicant]
WO WO0182922 · 2001 [cited by applicant]
WO WO0185116 · 2001 [cited by applicant]
WO WO02091846 · 2002 [cited by applicant]
WO WO2006026170 · 2006 [cited by applicant]
WO WO2006071653 · 2006 [cited by applicant]
WO WO2006071655 · 2006 [cited by applicant]
WO WO2006071654 · 2006 [cited by applicant]
WO WO2006101818 · 2006 [cited by applicant]
WO WO2006101864 · 2006 [cited by applicant]
WO WO2009101615 · 2009 [cited by applicant]
WO WO2010090855 · 2010 [cited by applicant]
WO WO11038797 · 2011 [cited by applicant]
WO WO2011106003 · 2011 [cited by applicant]
WO WO2011106493 · 2011 [cited by applicant]
WO WO2012002945 · 2012 [cited by applicant]
WO WO2012015408 · 2012 [cited by applicant]
WO WO2012084164 · 2012 [cited by applicant]
WO WO2012087289 · 2012 [cited by applicant]
WO WO2013036229 · 2013 [cited by applicant]
WO WO2013081627 · 2013 [cited by applicant]
WO WO2013089716 · 2013 [cited by applicant]
WO WO2013095361 · 2013 [cited by applicant]
WO WO2013095364 · 2013 [cited by applicant]
WO WO2014092747 · 2014 [cited by applicant]
WO 092014 · 2014 [cited by applicant]
WO WO2014131191A1 · 2014 [cited by examiner]
WO WO2015117957 · 2015 [cited by applicant]
WO WO2015123115 · 2015 [cited by applicant]
WO WO2016071827 · 2016 [cited by applicant]
WO WO2017011665 · 2017 [cited by applicant]
WO WO2017083363 · 2017 [cited by applicant]
WO WO2017194256 · 2017 [cited by applicant]
WO WO2019121319 · 2019 [cited by applicant]
WO WO2020083737 · 2020 [cited by applicant]
WO WO2021249760 · 2021 [cited by applicant]
WO WO20203030963 · 2023 [cited by applicant]
WO WO2023151986 · 2023 [cited by applicant]
Mathapathi et al. “Niacinamide leave-on formulation provides long-lasting protection against bacteria in vivo”. Experimental Dermatology. 26(9):827-829. (Year: 2017). [cited by examiner]
Guo-Ying Zuo et al.; In vitro synergism of magnolol and honokiol in combination with antibacterial agents against clinical isolates of methicillin-resistant [cited by applicant]
Lai Wah Chan et al.; Antimicrobial and antioxidant activities of Cortex Magnoliae Officinalis and some other medicinal plants commonly used in South-East Asia; Chinese Medicine; Nov. 28, 2008; pp. 1-10; 3:15; BioMed Cen… [cited by applicant]
Greenberg et al.; Compressed Mints and Chewing Gum Containing Magnolia Bark Extract Are Effective against Bacteria Responsible for Oral Malodor; Journal of Agricultural and Food Chemistry; Oct. 20, 2007; 9465-9469; 55; … [cited by applicant]
Guangjing Wufu; New Cosmetics Science; China Light Industry Press; Apr. 30, 1996; pp. 442-443, with English translation. [cited by applicant]
Anonymous; Novel Acne Cleansing and conditioning Lotion; Dr. Wu; Jul. 28, 2017; https://www.cosdna.com/chs/cosmetic_91f8301224.html; Cosdna. [cited by applicant]
GNPD Database (Online) Mintel; Sensitive Foam for Vulvovaginal Care; Procare Health Palomacare Espuma; Oct. 2015; pp. 1-6, with English translation, Record ID 3437909; Spain. [cited by applicant]
Notice of Opposition in EP18825643 (EP3727300); Jul. 28, 2023; with English translation; European Patent Office (EPO). [cited by applicant]
Stichwort: Benzalkoniumchlorid; Worterbuch der Kosmetik; 2004; pp. 1-3; with English translation. [cited by applicant]
Bin Liu; In vivo metabolism and analysis of traditional Chinese medicine ingredients; China Press of Traditional Chinese Medicine; Aug. 2011; p. 372, with English translation. [cited by applicant]
Drugbank Online; Dimethicone 100; 2022; pp. 1, Retrieved from Internet URL:https://go.drugbank.com/salts/DBSALT001523. [cited by applicant]
Poivre et al.; Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents; Biomed & Biotechnol; Mar. 2017; pp. 194-214; 18(3); J Zhejiang Univ-Sci B. [cited by applicant]
Luo et al.; Antifungal activity and potential mechanism of magnoflorine against Trichophyton rubrum; The Journal of Antibiotics; Oct. 20, 2020; pp. 206-214; 74; Japan Antibiotics Research Association; Japan. [cited by applicant]
Chemicalbook, Amphoteric surfactants; Chemical Products List; 2016; pp. 1-2, Retrieved from the Internet. [cited by applicant]
https://www.chemicalbook.com/ProductCatalog_EN/1813.htm#:˜:text=The%20lecithin%20%5B1%5D%20contained%20in,excellent%20emulsifying%20properties%20of%20oil. [cited by applicant]
Matsui, Hideo et al.; Synthesis and electronic behaviours of alternating indium-organic moiety binary hybrid copolymer; Databse Caplus (Online); 2006; pp. 1-2; XP002778749; Chemical Abstracts Service; United States of A… [cited by applicant]
Glidewell, Christopher et al.; Supramolecular chemistry of amine-phenol adducts; novel three-dimensional framework structures in adducts of bis . . . ; Database Caplus (Online); 2000; pp. 1-2; XP002778750; Chemical Abst… [cited by applicant]
Goldberg, David P et al.; A decanuclear mixed-valent manganese complex with a high spin multiplicity in the ground state; Database Caplus (Online); 1993; pp. 1-3; XP002778751; Chemical Abstracts Service; United States o… [cited by applicant]
Search Report and Written Opinion in EP17209949; Mar. 19, 2018; European Patent Office (EPO). [cited by applicant]
Search Report and Written Opinion in EP18202218; Dec. 19, 2018; European Patent Office (EPO). [cited by applicant]
Search Report and Written Opinion in PCTEP2018084749; Jan. 21, 2019; World Intellectual Property Org. (WIPO). [cited by applicant]
Search Report and Written Opinion in PCTEP2018085103; Jan. 31, 2019; World Intellectual Property Org. (WIPO). [cited by applicant]
Search Report and Written Opinion in EP17210127; May 4, 2018; European Patent Office (EPO). [cited by applicant]
Search Report and Written Opinoin in EP18213528; Jul. 19, 2019; European Patent Office (EPO). [cited by applicant]
Search Report and Written Opinoin in PCTEP201907817; Dec. 13, 2019; World Intellectual Property Org. (WIPO). [cited by applicant]
Search Report and Written Opinoin in PCTEP2019082564; Jan. 15, 2020; World Intellectual Property Org. (WIPO). [cited by applicant]
IPRP2 in PCTEP2018084749; May 13, 2020; World Intellectual Property Org. (WIPO). [cited by applicant]
IPRP1 in PCTEP2018085103; Jun. 23, 2020; World Intellectual Property Org. (WIPO). [cited by applicant]
GNPD Mintel; White Sunscreen; DHC; Jul. 2003; pp. 1-2, Record ID 214176; Japan. [cited by applicant]
GNPD Mintel; Eye Care; Martina Gebhardt Naturkosmetik; Nov. 2013; pp. 1-4, Record ID 2243030; Netherlands. [cited by applicant]
GNPD Mintel; Happy Aging Body Lotion; Martina Gebhardt Naturkosmetik; Feb. 2013; pp. 1-2, Record ID 1999361; Germany. [cited by applicant]
GNPD Mintel; Sheabutter Body Lotion; Martina Gebhardt Naturkosmetik; Feb. 2013; pp. 1-2, Record ID 1999393; Germany. [cited by applicant]
GNPD Mintel; Hand & Nail Hand Lotion; Martina Gebhardt Naturkosmetik; Feb. 2014; pp. 1-3, Record ID 2273913; Germany. [cited by applicant]
GNPD Mintel; Summer Time Face & Body Aftersun; Martina Gebhardt Naturkosmetik; Jul. 2015; pp. 1-3, Record ID 3058213; Germany. [cited by applicant]
Gnpd Mintel; Summer Time Face & Body Lotion; Martina Gebhardt Naturkosmetik; Jul. 2015; pp. 1-3, Record ID 3058215; Germany. [cited by applicant]
GNPD Mintel; Ginseng Cream; Martina Gebhardt Naturkosmetik; Feb. 2016; pp. 1-4, Record ID 3755787; Germany. [cited by applicant]
GNPD Mintel; Tassilo Linde; Martina Gebhardt Naturkosmetik; Jul. 2016; pp. 1-4, Record ID 4171881; Germany. [cited by applicant]
GNPD Mintel; Eye Care Fluid; Martina Gebhardt Naturkosmetik; Jun. 2017; pp. 1-3, Record ID 4855347; Germany. [cited by applicant]
Anonymous; Emergence EXO Serum Intensive; The Skin Saint; PP1, https://theskinsaint.com/products/emergence□exo□serum□intensive. [cited by applicant]
GNPD Mintel; Day Cream SPF 10; Oriflame Optimals Vital Definition; May 2014; pp. 1-3, Record ID 2433677; Greece. [cited by applicant]
GNPD Mintel; Swiss Allure Skrab dlya Litsa (Exfoliating Gentle Peeling); Medena; Feb. 2017; pp. 1-2, Record ID 4594303; Russian Federation. [cited by applicant]
Anonymous; Vinoderm Gentle Peeling; Hair-France.fr; pp. 1-2, https://www.hair□france.fr/fr/cleansing/792□791□creme□gommante□vinoderm.html; .; France. [cited by applicant]
Written Opinion 2 in PCTEP2019078179; Oct. 16, 2020; World Intellectual Property Org. (WIPO). [cited by applicant]
IPRP2 in PCTEP2019078179; Jan. 29, 2021; World Intellectual Property Org. (WIPO). [cited by applicant]
G. Kampf; Journal of Hospital Infection; Efficacy of ethanol in viruses in hand disinfection; Apr. 1, 2018; pp. 331-338; XP055714645; vol. 98, No. 4; Elsevier Ltd; Netherlands. [cited by applicant]
Malik et al.; AJIC: American Journal of Infection Control; Comparative efficacy of ethanol and isoprpanol against feline calicivirus, a norovirus surrogate; Feb. 1, 2006; pp. 31-35; XP005442120; vol. 34 No 1; Elsevier; … [cited by applicant]
WR Moorer; Anitiviral activity of alcohol for surface disinfection; International Journal of Dental Hygiene; Jan. 1, 2003; pp. 138-142, XP055834836; vol. 1, No. 1; Blackwell Munksgaard; Netherlands. [cited by applicant]
Diphenyl; National Institute for Occupational Safety and Health; 2019; pp. 1-3. [cited by applicant]
Search Report and Written Opinion in EP23213180; May 8, 2024; European Patent Office (EPO). [cited by applicant]
Stephen M. Mudge; Fatty Alcohols—a review of their natural synthesis and environmental distribution; Nov. 2005; pp. 1-153; The Soap and Detergent Association. [cited by applicant]
Search Report and Written Opinion in EP24150487; Jun. 25, 2024; European Patent Office (EPO). [cited by applicant]
GNPD Database (Online) Mintel; Brightening Under Eye Gel; Simple Protect ‘n’ Glow; Nov. 2023; pp. 1-4, Record ID 11299696, XP093171437; India. [cited by applicant]
GNPD Database (Online) Mintel; White Cloud Spot Corrector; Skyn Iceland; Jan. 2013; pp. 1-6, Record ID 1966690, XP093171340; United Kingdom. [cited by applicant]
GNPD Database (Online) Mintel; Anti-Aging Daily Serum 2.0; Elizabeth Arden Prevage; Mar. 2021; pp. 1-7, Record ID 8553989, XP093171361; United Kingdom. [cited by applicant]
GNPD Database (Online) Mintel; Whitening Morning Yogurt; Naruko Raw Job's Tears Supercritical CO2; Nov. 2011; pp. 1-6, Record ID 1663269, XP093171456; Singapore. [cited by applicant]
Shen Zhengyi et al.; Hospital Infection Diseases, Part 2; China Medical Science and Technology Press; Apr. 2007; pp. 1442 with English translation; 1st edition, 1st printing; China. [cited by applicant]