IP Library › Granted Patent US 12,397,031
Granted Patent B2
US 12,397,031 · App. 17/299,893 · Granted Aug 26, 2025

Patent

Inventors: Jeom Yong Kim (Seongnam-si, KR); Sun Kyu Park (Seongnam-si, KR); Min Jung Jang (Seongnam-si, KR); Jong Hoon Lee (Seongnam-si, KR); Su Hwan Lim (Seongnam-si, KR)
Assignee: Green Cross Wellbeing Corporation
A61K36/355A23L2/52A23L33/105A23P10/28A23P10/30A61K31/7048A61P31/04A23V2002/00
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Quick Facts
Patent No.
US 12,397,031
App. No.
17/299,893
Granted
Aug 26, 2025
Kind
B2
Abstract

The present invention pertains to a Lonicera japonica flower water extract composition for preventing or treating Helicobacter pylori infection, the composition containing secoxyloganin as an active ingredient. The extract contains a specific amount of secoxyloganin, and thus exhibited excellent antibacterial effects when used on Helicobacter pylori bacteria, and exhibited excellent effects in terms of reducing Helicobacter pylori IgG antibody expression in the blood, alleviating histopathological lesions, and reducing cytokine expression when used on Helicobacter pylori -infected mice. Thus, the Lonicera japonica flower water extract of the present invention can be usefully used as a composition for preventing or treating Helicobacter pylori infection.

Claims (6)

1. A method for treating Helicobacter pylori infection in a subject in need thereof, comprising administering an effective amount of a composition comprising Lonicera japonica flower water extract or secoxyloganin as an active ingredient, to the subject, wherein the Lonicera japonica flower water extract contains secoxyloganin,

wherein the secoxyloganin is contained in 0.5 to 5 wt % in the Lonicera japonica flower water extract, and

wherein the Lonicera japonica flower water extract is obtained by mixing Lonicera japonica flower with 1500 to 2500 parts by weight of water with respect to 100 parts by weight of Lonicera japonica flower, and then extracting a resulting mixture for 1 to 5 hours at a temperature of 90° C.

2. The method of claim 1 , wherein the composition is a pharmaceutical composition or a foodstuff.

3. The method of claim 2 , wherein the pharmaceutical composition further comprises a pharmaceutically acceptable carrier, an excipient or a diluent.

4. The method of claim 2 , wherein the foodstuff is in a form of a tablet, a capsule, a pill, or a liquid.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 4, 2021
From: KIM, JEOM YONG; PARK, SUN KYU; JANG, MIN JUNG; LEE, JONG HOON; LIM, SU HWAN
To: GREEN CROSS WELLBEING CORPORATION
Reel/Frame 056439/0532 →
Priority Claims (1)
KR 10-2018-0155638 · Dec 6, 2018 · national
Continuity (1)
Related Publication 20220023366A1 · Jan 27, 2022
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