IP Library › Granted Patent US 12,466,867
Granted Patent B2
US 12,466,867 · App. 17/304,585 · Granted Nov 11, 2025

Methods for activation and expansion of natural killer cells and uses thereof

Inventors: Lucila Nassif Kerbauy (Houston, TX); Elizabeth Shpall (Houston, TX); Katy Rezvani (Houston, TX)
Assignee: Board of Regents, The University of Texas System
C07K14/5434A61K40/15A61K40/31A61K40/35A61K40/4211A61K40/4217C07K14/5443C07K14/55C07K14/70592C07K14/70596C12N5/0646
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Quick Facts
Patent No.
US 12,466,867
App. No.
17/304,585
Granted
Nov 11, 2025
Kind
B2
Abstract

Provided herein are methods for pre-activating and expanding an isolated population of NK cells. Further provided herein are methods for the treatment of cancer by administering the pre-activated and expanded NK cells.

Claims (12)

1 . A method for treating cancer in an individual in need thereof, comprising administering to the individual in need thereof a therapeutically effective amount of ex vivo-combined pre-activated NK cells and a monoclonal, bispecific, or trispecific antibody, wherein the antibody binds an NK cell receptor to redirect the NK cells to a target tumor cell, wherein

(a) the NK cells are produced by the step of pre-activating the population of NK cells in a pre-activation culture comprising an effective concentration of IL-12, IL-15, and IL-18 to obtain pre-activated NK cells and then

(b) expanding the pre-activated NK cells in an expansion culture comprising artificial antigen presenting cells (aAPCs) expressing CD 137 ligand.

2 . The method of claim 1 , wherein the NK cell receptor is CD16 or CD56.

3 . The method of claim 1 , wherein the NK cells express a chimeric antigen receptor.

4 . The method of claim 1 , wherein the cancer is a solid tumor or a hematological tumor.

5 . The method of claim 1 , wherein the cells are CD56 + NK cells.

6 . The method of claim 1 , wherein the NK cells and/or the antibodies are administered intravenously, intraperitoneally, intratracheally, intratumorally, intramuscularly, endoscopically, intralesionally, percutaneously, subcutaneously, regionally, by direct injection or perfusion.

7 . The method of claim 1 , wherein the NK cells are autologous or allogeneic with respect to the individual.

8 . The method of claim 1 , wherein the aAPCs express membrane bound IL-21.

9 . The method of claim 1 , wherein the pre-activating step is for 16 hours.

10 . The method of claim 1 , wherein the expansion culture further comprises IL-2.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 23, 2021
From: KERBAUY, LUCILA NASSIF; SHPALL, ELIZABETH; REZVANI, KATY
To: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
Reel/Frame 056638/0756 →
Continuity (3)
Continuation 16970937
Provisional Application 62633592 · Feb 21, 2018
Related Publication 20220118013A1 · Apr 21, 2022
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