SPARC-derived tumor rejection antigenic peptides and medicaments comprising the same
It is an objective of the present invention to identify SPARC protein-derived peptides that are able to induce human killer T cells and helper T cells having cytotoxic activity to tumors, and to provide a means for carrying out a tumor immunotherapy of patients with various types of cancers overexpressing SPARC. The present invention provides a peptide of any of the following: (A) a peptide which consists of the amino acid sequence as shown in any one of SEQ ID NOS: 1 to 3; or (B) a peptide which consists of an amino acid sequence comprising a substitution or addition of one or several amino acids with respect to the peptide consisting of the amino acid sequence as shown in any one of SEQ ID NOS: 1 to 3, and which has capacity to induce cytotoxic (killer) T cells.
1. An isolated peptide of any of the following:
(A) a peptide which consists of the amino acid sequence as shown in SEQ ID NO: 3; or
(B) a peptide which consists of the amino acid sequence as shown in SEQ ID NO: 3 in which one to three amino acids have been substituted or added, and which has capacity to induce cytotoxic (killer) T cells.
2. A composition which comprises at least one type of the peptide of claim 1 .
3. An isolated antigen-presenting cell, which comprises a complex of an HLA molecule and the peptide of claim 1 .