Multimodal therapy for cancer cell destruction
The field of the disclosure relates generally to cancer cell destruction and, more specifically, to cancer cell destruction by photo-magnetic irradiation mediated multimodal therapy using smart nanostructures.
1. A multimodal method of cancer cell destruction, the method comprising:
interacting at least one nanostructure with at least one cancer cell, wherein the at least one nanostructure comprises a cluster of nanoparticles, and wherein the cluster comprises at least one core-shell magnetic nanosphere (CSMNS) nanoparticle comprising a magnetic nanoparticle (MNP) core and at least one capped gold nanoparticle (AuNP);
applying optical irradiation induced temperature change to the at least one nanostructure;
simultaneously applying an oscillating magnetic field to the at least one nanostructure; and
inducing a coupled hyperthermia and oxidative stress to destroy the at least one cancer cell through the simultaneous optical irradiation and oscillating magnetic field application.
2. The method of claim 1 , wherein the simultaneous application of optical irradiation and oscillating magnetic field occur with an incubator-actuator device.
3. The method of claim 1 , wherein the oscillating magnetic field has an intensity of from about 0 Oe to about 150 Oe.
4. The method of claim 1 , wherein the oscillating magnetic field has a frequency of from about 0 kHz to about 1,000 kHz.
5. The method of claim 1 , wherein the at least one CSMNS nanoparticle has a diameter of from about 50 nm to about 400 nm.
6. The method of claim 1 , wherein the nanostructure comprises the at least one CSMNS nanoparticle at a concentration of from about 200 μg/ml to about 600 μg/ml.
7. The method of claim 1 , wherein the at least one CSMNS nanoparticle comprises a polymer shell.
8. The method of claim 7 , wherein the MNP core is selected from at least one of magnetite, ferric oxide, maghemite, gadolinium-doped cobalt ferrite, and combinations thereof.
9. The method of claim 7 , wherein the polymer shell comprises polyvinylpyrrolidone (PVP).
10. The method of claim 1 , wherein the nanostructure comprises the at least one capped AuNP at a concentration of from about 0.5 μg/ml to about 6 μg/ml.
11. The method of claim 1 , wherein the at least one capped AuNP is capped with a material comprising at least one of polyvinylpyrrolidone (PVP), polyethylene glycol (PEG), poly(N-isopropylacrylamide) (PNIPAM), dextran, dimercaptosuccinic acid (DMSA) and combinations thereof.
12. A nanostructure for cancer cell destruction, the nanostructure comprising:
a cluster of nanoparticles comprising:
at least one core-shell magnetic nanosphere (CSMNS) nanoparticle and at least one capped gold nanoparticle (AuNP);
wherein the at least one CSMNS nanoparticle comprises a magnetic nanoparticle (MNP) core.
13. The nanostructure of claim 12 , wherein the at least one CSMNS nanoparticle has a diameter of from about 50 nm to about 400 nm.
14. The nanostructure of claim 12 , wherein the nanostructure comprises the at least one CSMNS nanoparticle at a concentration of from about 200 μg/ml to about 600 μg/ml.
15. The nanostructure of claim 12 , wherein the MNP core is selected from at least one of magnetite, ferric oxide, maghemite, gadolinium-doped cobalt ferrite, and combinations thereof.
16. The nanostructure of claim 12 , wherein the at least one CSMNS nanoparticle comprises a polymer shell.
17. The nanostructure of claim 16 , wherein the polymer shell comprises polyvinylpyrrolidone (PVP).
18. The nanostructure of claim 12 , wherein the nanostructure comprises the at least one capped AuNP at a concentration of from about 0.5 μg/ml to about 6 μg/ml.
19. The nanostructure of claim 12 , wherein the at least one capped AuNP is capped with a material comprising at least one of polyvinylpyrrolidone (PVP), polyethylene glycol (PEG), poly(N-isopropylacrylamide) (PNIPAM), dextran, dimercaptosuccinic acid (DMSA) and combinations thereof.