IP Library Granted Patent US 12,181,076
Granted Patent B2
US 12,181,076 · App. 17/306,513 · Granted Dec 31, 2024

Encapsulated valve system and method of use

Inventors: Michael C. Gagne (Carson City, NV); Steven V. Cates (Corona, CA)
Assignee: Repligen Corporation
F16K7/04F16K3/30F16K7/00F16K7/045F16K7/06F16K7/07F16K11/027F16K11/10F16K27/003F16K31/0655F16K7/066Y10T137/60Y10T137/87153Y10T137/87684Y10T137/87708Y10T137/87885Y10T137/87925
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,181,076
App. No.
17/306,513
Granted
Dec 31, 2024
Kind
B2
Abstract

An encapsulated valve system includes a first housing portion having a first facing surface, the first facing surface comprising a plurality of branch pathways formed as a recess within the first facing surface. The valve system further includes a second housing portion having a second facing surface, the second facing surface comprising a plurality of branch pathways formed as a recess within the second facing surface. A disposable conduit is configured to be interposed between the first and second housing portions and disposed within the recess of the first facing surface and the recess of the second facing surface. The disposable conduit is thus sandwiched between the first and second facing surfaces. A plurality of pinch valve actuators are mounted on one or both of the first housing portion and the second housing portion, the plurality of pinch valve actuators configured to pinch the disposable conduit at selective branch pathways.

Claims (43)

1. An encapsulated valve system for pharmaceutical or biological liquid fluids, said valve system comprising:

a first housing portion having a first facing surface; and

a second housing portion having a second facing surface and configured to be separably coupleable with said first housing portion;

wherein:

said first facing surface includes a first plurality of branch passageways and a common passageway bridging said first plurality of branch passageways formed as a first recess within said first facing surface;

said second facing surface includes a second plurality of branch passageways and a common passageway bridging said second plurality of branch passageways formed as a second recess within said second facing surface, the first and second plurality of branch passageways extending from said common passageway in a single lateral direction;

said first recess and said second recess are shaped and configured to form a conduit passageway shaped and configured to encapsulate a disposable conduit therein;

at least one first aperture is provided in communication with said first plurality of branch passageways, the at least one first aperture dimensioned to receive a first valve element; and

at least one second aperture is provided in communication with said second plurality of branch passageways, the at least one second aperture dimensioned to receive a second valve element;

the valve system further comprising:

a first pinch valve with a first pinching element extending into one of said at least one first aperture provided in communication with said first plurality of branch passageways; and

a second pinch valve with a second pinching element extending into one of said at least one second aperture provided in communication with said second plurality of branch passageways;

wherein:

said at least one first aperture provided in communication with said first plurality of branch passageways is located spaced apart from said at least one second aperture provided in communication with said second plurality of branch passageways; and

said first pinch valve is positioned to pinch only a first side of a conduit disposed within said conduit passageway, and said second pinch valve is positioned to pinch only a second side of the conduit disposed within said conduit passageway, the first side and second side being opposite sides of the conduit.

2. The encapsulated system of claim 1 , further comprising the disposable conduit shaped to be encapsulated within said conduit passageway formed by said first recess and said second recess.

3. The encapsulated system of claim 2 , wherein said disposable conduit is formed of an unreinforced silicone tubing.

4. The encapsulated system of claim 1 , further comprising at least one common passageway aperture is provided in communication with said common passageway.

5. The encapsulated system of claim 4 , further comprising:

a common pinch valve with a pinching element extending into said common passageway aperture;

wherein:

said first branch pinch valve is positioned to control fluid flow through a first branch passageway;

said second pinch valve is positioned to control fluid flow through a second branch passageway different from said first branch passageway; and

said common pinch valve is positioned to control fluid flow through said common passageway.

6. The encapsulated system of claim 5 , further comprising at least one automatically-controlled pinch valve actuator controlling at least one of said first pinch valve or said second pinch valve or said common pinch valve.

7. The encapsulated system of claim 5 , further comprising at least one manually-controlled pinch valve actuator controlling at least one of said first pinch valve or said second pinch valve or said common pinch valve.

8. The encapsulated system of claim 1 , wherein said plurality of branch passageways terminate at respective flange fittings.

9. The encapsulated system of claim 8 , wherein said disposable conduit includes a seal or gasket at least one terminal end thereof dimensioned to fit within a recess in one of said flange fittings.

10. The encapsulated system of claim 1 , wherein said plurality of branch passageways terminate in plain tube endings.

11. An encapsulated valve system comprising:

a first housing portion; and

a second housing portion;

wherein:

said first housing portion and said second housing portion are formed separately and, when facing surfaces thereof are brought into contact, form an inlet passageway, a plurality of enclosed branch passageways including at least first and second branch passageways and a common passageway bridging said inlet passageway and said plurality of enclosed branch passageways including said first and second branch passageways, each of the plurality of enclosed branch passageways including said first and second branch passageways extending from the common passageway and from the first and second housing portions through only a first lateral side thereof;

a disposable conduit is extendable within said inlet passageway, said branch passageways, and said common passageway to be encapsulated therein; and

a common passageway aperture formed in said first housing portion, said common passageway aperture being in communication with said common passageway, said common passageway aperture being positioned between said first and second branch passageways.

12. The encapsulated valve system of claim 11 , further comprising:

a first pinch valve actuator mounted on said first housing portion with a pinching element passing through said common passageway aperture to contact a portion of the disposable conduit within said common passageway.

13. The encapsulated valve system of claim 11 , further comprising at least one valve positioned to gate a fluid medium flowing through the disposable conduit within said plurality of enclosed branch passageways and said common passageway into one or more selected branch passageways.

14. The encapsulated valve system of claim 11 , wherein the disposable conduit is made of unreinforced silicone tubing, said first and second housing portions forming an exoskeleton encapsulating said disposable conduit.

15. The encapsulated valve system of claim 11 , further comprising a disposable conduit encapsulated within said branch passageways and said common passageway, wherein:

said plurality of branch passageways terminate at respective flange fittings; and

said disposable conduit includes a seal or gasket at least one terminal end thereof dimensioned to fit within a recess in one of said flange fittings.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 19, 2024
From: ALPHINITY, LLC
To: REPLIGEN CORPORATION
Reel/Frame 068636/0413 →
Continuity (6)
Continuation 16267997 · Feb 5, 2019
Continuation 15252134 · Aug 30, 2016
Continuation 14165206 · Jan 27, 2014
Continuation 13554983 · Jul 20, 2012
Continuation 12466918 · May 15, 2009
Related Publication 20210254729A1 · Aug 19, 2021