IP Library › Granted Patent US 12,409,257
Granted Patent B2
US 12,409,257 · App. 17/308,567 · Granted Sep 9, 2025

Peritoneal oxygenation system and method

Inventors: Joseph Friedberg (Baltimore, MD); Hosam Fathy (Kensington, MD); Jin-Oh Hahn (Potomac, MD); Mahsa Doosthosseini (Laurel, MD); Majid Aroom (Preston, MD); Kevin Aroom (Silver Spring, MD)
Assignees: UNIVERSITY OF MARYLAND, BALTIMORE; UNIVERSITY OF MARYLAND, COLLEGE PARK
A61M1/28A61M1/282A61M1/32A61M1/369A61M2202/0476A61M2210/1017A61M2210/1021
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Quick Facts
Patent No.
US 12,409,257
App. No.
17/308,567
Granted
Sep 9, 2025
Kind
B2
Abstract

Systems and methods for gas exchange in a patient are provided that use an external circuit to cause oxygenation perfusion in a body cavity (such as an abdomen) of the patient using an inert chemical (e.g., perfluorocarbon), independent of lungs. The external circuit includes components configured to control properties of the chemical, including temperature, flow rate, pressure, oxygenation percentage, and carbon dioxide percentage. The systems also include safety features to reduce a likelihood of injury to the patient. Each of the safety features and the properties of the chemical can be controlled by a healthcare worker, such as a physician, a nurse, or an emergency operator, for a particular patient.

Claims (30)

1. A system for peritoneal oxygenation, the system comprising:

a suction canister system having fluidly separated portions;

a gas exchanger comprising a carbon dioxide removal tank and an oxygenation tank;

wherein said gas exchanger is in fluid communication with said suction canister system and is configured for fluid coupling to a patient's abdominal cavity; and

a controller configured to cause each of said fluidly separated portions to alternate between suctioning an oxygenation fluid from the patient's abdominal cavity and feeding the oxygenation fluid to the gas exchanger.

2. The system for peritoneal oxygenation of claim 1 , wherein each of said fluidly separated portions comprises one of a plurality of fluid canisters, wherein a first one of said fluid canisters has a first inlet valve and a first outlet valve, and wherein a second one of said fluid canisters has a second inlet valve and a second outlet valve.

3. The system for peritoneal oxygenation of claim 2 , wherein said controller is further configured to position said first inlet valve open when said second inlet valve is closed, and wherein said controller is further configured to position said second inlet valve open when said first inlet valve is closed.

4. The system for peritoneal oxygenation of claim 3 , wherein said controller is further configured to position said first outlet valve closed when said first inlet valve is open, and wherein said controller is further configured to position said second outlet valve open when said second inlet valve is closed.

5. The system for peritoneal oxygenation of claim 3 , wherein each of said fluid canisters further comprises a valve configured to vent to atmosphere.

6. The system for peritoneal oxygenation of claim 3 , wherein each of said fluid canisters further comprises a valve configured to fluidly connect each of said fluid canisters to a vacuum source.

7. The system for peritoneal oxygenation of claim 1 , wherein said controller is further configured to transition a first one of said fluidly separated portions from suctioning said oxygenation fluid from the patient's abdominal cavity to feeding of said oxygenation fluid that has been suctioned to said gas exchanger upon said oxygenation fluid that has been suctioned reaching a predesignated maximum fill level in said first one of said fluidly separated portions.

8. The system for peritoneal oxygenation of claim 7 , wherein said controller is further configured to simultaneously transition a second one of said fluidly separated portions from feeding said oxygenation fluid to suctioning said oxygenation fluid upon transitioning said first one of said fluidly separated portions from suctioning said oxygenation fluid to feeding said oxygenation fluid.

9. The system for peritoneal oxygenation of claim 1 , further comprising a pump between and in fluid communication with each of said suction canister system and said gas exchanger.

10. The system for peritoneal oxygenation of claim 9 , wherein said controller is further configured to set a flow rate of said pump to zero upon either a first one of said fluidly separated portions or a second one of said fluidly separated portions having an oxygenation fluid level below a predetermined minimum level.

11. A method for peritoneal oxygenation, the method comprising:

providing a system for the peritoneal oxygenation, the system comprising:

a suction canister system having fluidly separated portions;

a gas exchanger comprising a carbon dioxide removal tank and an oxygenation tank;

wherein said gas exchanger is in fluid communication with said suction canister system and is configured for fluid coupling to a patient's abdominal cavity; and

a controller; and

causing said system to alternate operation of each of said fluidly separated portions between suctioning an oxygenation fluid from the patient's abdominal cavity and feeding said oxygenation fluid to the gas exchanger.

12. The method for peritoneal oxygenation of claim 11 , further comprising controlling a temperature of said oxygenation fluid at a point of perfusion into said patient to substantially match a body temperature of the patient.

13. The method for peritoneal oxygenation of claim 12 , further comprising heating said oxygenation fluid in said carbon dioxide removal tank to a second temperature above said body temperature of said patient, wherein said second temperature is selected to increase carbon dioxide removal in said carbon dioxide removal tank.

14. The method for peritoneal oxygenation of claim 11 , wherein each of said fluidly separated portions comprises one of a plurality of fluid canisters, wherein a first one of said fluid canisters has a first inlet valve and a first outlet valve, and wherein a second one of said fluid canisters has a second inlet valve and a second outlet valve.

15. The method for peritoneal oxygenation of claim 14 , further comprising steps of positioning said first inlet valve open when said second inlet valve is closed, and positioning said second inlet valve open when said first inlet valve is closed.

16. The method for peritoneal oxygenation of claim 15 , further comprising steps of positioning said first outlet valve closed when said first inlet valve is open, and positioning said second outlet valve open when said second inlet valve is closed.

17. The method for peritoneal oxygenation of claim 15 , wherein each of said fluid canisters further comprises a valve configured to vent to atmosphere.

18. The method for peritoneal oxygenation of claim 15 , wherein each of said fluid canisters further comprises a valve configured to fluidly connect each of said fluid canisters to a vacuum source.

19. The method for peritoneal oxygenation of claim 11 , further comprising a step of transitioning a first one of said fluidly separated portions from suctioning said oxygenation fluid from the patient's abdominal cavity to feeding of said oxygenation fluid that has been suctioned to said gas exchanger upon said oxygenation fluid that has been suctioned reaching a predesignated maximum fill level in said first one of said fluidly separated portions.

20. The method for peritoneal oxygenation of claim 19 , further comprising a step of simultaneously transitioning a second one of said fluidly separated portions from feeding said oxygenation fluid to suctioning said oxygenation fluid upon transitioning said first one of said fluidly separated portions from suctioning said oxygenation fluid to feeding said oxygenation fluid.

Assignments (3)
CONFIRMATORY LICENSE Recorded Apr 3, 2025
From: UNIV OF MARYLAND, COLLEGE PARK
To: NATIONAL SCIENCE FOUNDATION
Reel/Frame 070731/0702 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 19, 2023
From: AROOM, KEVIN; FATHY, HOSAM K.; HAHN, JIN-OH; AROOM, MAJID; DOOSTHOSSEINI, MAHSA
To: UNIVERSITY OF MARYLAND, COLLEGE PARK
Reel/Frame 062423/0446 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 14, 2021
From: FRIEDBERG, JOSEPH
To: UNIVERSITY OF MARYLAND, BALTIMORE
Reel/Frame 056534/0441 →
Continuity (2)
Provisional Application 63020207 · May 5, 2020
Related Publication 20210346582A1 · Nov 11, 2021
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