IP Library › Granted Patent US 12,227,515
Granted Patent B2
US 12,227,515 · App. 17/309,259 · Granted Feb 18, 2025

In-flow photooxygenation of aminothienopyridinones generates novel PTP4A3 phosphatase inhibitors

Inventors: John S. Lazo (Charlottesville, VA); Elizabeth Sharlow (Butler, PA); Peter Wipf (Pittsburgh, PA); Nikhil Tasker (Trumbull, CT); Ettore Rastelli (Pittsburgh, PA)
Assignees: University of Virginia Patent Foundation; University of Pittsburgh—Of the Commonwealth System of Higher Education
C07D495/04
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Quick Facts
Patent No.
US 12,227,515
App. No.
17/309,259
Granted
Feb 18, 2025
Kind
B2
Abstract

The disclosure provides compounds that inhibit protein tyrosine phosphatase, such as protein tyrosine phosphatase 4 A3 (PTP4A3). The disclosure also provides pharmaceutical compositions, uses, and methods of using the compounds, such as in the treatment of cancers.

Claims (16)

1. A compound, or a pharmaceutically acceptable salt thereof, selected from one of the following compounds

15

9e

NRT- 892- 04

9p

9m

9n

9o

9q

2. A method for treating a subject suffering from cancer, the method comprising administering to the subject a therapeutically effective amount of a compound according to claim 1 or a pharmaceutically acceptable salt thereof to treat the cancer.

3. The method according to claim 2 , wherein the cancer is selected from the group consisting of colorectal cancer, breast cancer, ovarian cancer, cervical cancer, lung cancer, liver cancer, stomach cancer, stromal cancer, leukemia, and lymphoma.

4. The method according to claim 3 , wherein the cancer is breast cancer or ovarian cancer.

5. The method according to claim 4 , wherein the cancer is triple negative breast cancer or advanced ovarian cancer.

6. A method for inhibiting a protein-tyrosine phosphatase in a cell, comprising contacting the cell with a compound according to claim 1 or a pharmaceutically acceptable salt thereof.

7. The method according to claim 6 , wherein the protein tyrosine phosphatase is protein tyrosine phosphatase 4A3 (PTP4A3).

8. A pharmaceutical composition comprising a therapeutically effective amount of a compound, or a pharmaceutically acceptable salt thereof, according to claim 1 .

Assignments (3)
CONFIRMATORY LICENSE Recorded Nov 10, 2022
From: UNIVERSITY OF VIRGINIA
To: UNITED STATES GOVERNMENT
Reel/Frame 061912/0660 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 21, 2021
From: LAZO, JOHN S.; SHARLOW, ELIZABETH
To: UNIVERSITY OF VIRGINIA
Reel/Frame 056309/0643 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 21, 2021
From: WIPF, PETER; TASKER, NIKHIL; RASTELLI, ETTORE
To: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
Reel/Frame 056309/0701 →
Continuity (4)
Provisional Application 62870252 · Jul 3, 2019
Provisional Application 62758759 · Nov 12, 2018
Provisional Application 62758861 · Nov 12, 2018
Related Publication 20220017534A1 · Jan 20, 2022
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