Synthesis for 3-bromo-5-(2-ethylimidazo[1, 2-alpha]pyridine-3-carbonyl)-2-hydroxybenzonitrile
A method for synthesizing 3-bromo-5-(2-ethylimidazo[1,2-a] pyridine-3-carbonyl)-2-hydroxybenzonitrile, particularly relates to a method for synthesizing a compound represented by a formula (III), and particularly relates to step A or step B; step A: a compound represented by a formula (I) and a compound represented by a formula (II) are first heated in an organic solvent to react, and the resulting reaction product and a base are heated in the presence of water to continue the reaction to obtain a compound represented by a formula (III); and step B: a compound represented by the formula (I), a compound represented by a formula (II), and a base are heated in an organic solvent to react, and the resulting reaction product is heated in the presence of water to continue the reaction to obtain a compound represented by a formula (III).
1. A method for synthesizing a compound represented by formula (III), comprising step A or step B,
Step A: a compound represented by formula (I) and a compound represented by formula (II) are first heated in an organic solvent to react, and the resulting reaction product and a base are heated in the presence of water to continue the reaction to obtain a compound represented by formula (III);
Step B: a compound represented by formula (I), a compound represented by formula (II), and the base are heated in an organic solvent to react, and the resulting reaction product is heated in the presence of water to continue the reaction to obtain a compound represented by formula (III);
wherein, R 1 is H or C1-3 alkyl, R 2 is H, —CN, I or Br, R 3 is H, I or Br, and R 4 is Cl, Br or I; the organic solvent is selected from the group consisting of toluene, xylene, ethyl acetate, isopropyl acetate, isopropanol, ethanol, N-methyl-2-pyrrolidone (NMP), tert-butanol, dimethylformamide (DMF) and acetonitrile;
wherein the base is selected from the group consisting of sodium carbonate, potassium carbonate, sodium bicarbonate, potassium bicarbonate, triethylamine, diisopropylethylamine, lithium hydroxide, sodium hydroxide and potassium hydroxide.
2. The method according to claim 1 , wherein the reaction temperature of the compound represented by formula (I) and the compound represented by formula (II) is 75 to 150° C. the temperature for continuing the reaction is 50 to 100° C.
3. The method according to claim 1 , wherein the organic solvent is ethyl acetate.
4. The method according to claim 1 , wherein in step A, the base is added to such an amount that the pH value of the reaction solution that continues to react reaches 4 to 7; in step B, the amount of the base added is 0.1 to 2.5 times the moles of the compound represented by formula (II).
5. The method according to claim 2 , wherein the reaction temperature of the compound represented by formula (I) and the compound represented by formula (II) is 77 to 100° C.; the temperature for continuing the reaction is 60 to 100° C.
6. The method according to claim 4 , wherein the base is sodium bicarbonate; in step B, the amount of the base added is 0.5 to 2.5 times the moles of the compound represented by formula (II).