IP Library Granted Patent US 12,252,697
Granted Patent B2
US 12,252,697 · App. 17/310,994 · Granted Mar 18, 2025

Herbicide tolerant plants and production and detection of same

Inventors: Todd Gaines (Fort Collins, CO); Marcelo Rodrigues Alves De Figueiredo (Fort Collins, CO); Anita Küpper (Fort Collins, CO); Christopher Preston (Fort Collins, CO)
Assignees: Colorado State University Research Foundation; University of Adelaide
C12N15/8274C07K14/415C12Q1/6895
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Quick Facts
Patent No.
US 12,252,697
App. No.
17/310,994
Granted
Mar 18, 2025
Kind
B2
Abstract

The present invention refers to a plant or plant part comprising a polynucleotide encoding an herbicide tolerant IAA2 polypeptide having a deleted or disrupted degron tail region, the expression of said polynucleotide confers to the plant or plant part tolerance to synthetic auxin herbicides, such as 2,4-D. The present invention relates to methods and plants and that have a deleted or disrupted degron tail region of the IAA2 protein obtained by gene editing, transformation, mutagenesis, breeding, and the like.

Claims (8)

1. A method of producing a plant having tolerance to an herbicide, the method comprising:

introducing a heterologous nucleic acid encoding an Aux/IAA polypeptide having a deleted or disrupted degron tail of domain II of the Aux/IAA protein into the plant, wherein the heterologous nucleic acid comprises a nucleotide sequence having at least 80% sequence identity to SEQ ID NO: 4 or encodes a polypeptide comprising an amino acid sequence having at least 80% sequence identity to SEQ ID NO: 3.

2. The method of claim 1 , wherein the heterologous nucleic acid comprises a nucleotide sequence having at least 95% sequence identity to SEQ ID NO: 4 or encodes a polypeptide comprising an amino acid sequence having at least 95% sequence identity to SEQ ID NO: 3.

3. The method of claim 1 , wherein said herbicide is a synthetic auxin herbicide.

4. The method of claim 3 , wherein said herbicide is selected from 2,4-dichlorophenoxyacetic acid, dicamba, dichlorprop, clopyralid, fluroxypyr, florpyrauxifen-benzyl, and 2-methyl-4-chlorophenoxyacetic acid.

5. The method of claim 4 , wherein said herbicide is 2,4-dichlorophenoxyacetic acid.

6. The method of claim 1 , wherein said plant is a member of the Brassicaceae family.

7. The method of claim 1 , wherein the heterologous nucleic acid comprises the nucleotide sequence set forth in SEQ ID NO: 4 or encodes a polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 3.

Assignments (3)
NUNC PRO TUNC ASSIGNMENT Recorded Jun 2, 2026
From: THE UNIVERSITY OF ADELAIDE
To: ADELAIDE UNIVERSITY
Reel/Frame 075843/0344 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 30, 2021
From: GAINES, TODD; RODRIGUES ALVES DE FIGUEIREDO, MARCELO; KÜPPER, ANITA
To: COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
Reel/Frame 058243/0574 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 30, 2021
From: PRESTON, CHRISTOPHER
To: UNIVERSITY OF ADELAIDE
Reel/Frame 058243/0584 →
Continuity (3)
Provisional Application 62963630 · Jan 21, 2020
Provisional Application 62816773 · Mar 11, 2019
Related Publication 20220127633A1 · Apr 28, 2022
References Cited (10)
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LeClere et al., “Cross-resistance to dicamba, 2,4-D, and fluroxypyr in Kochia scoparia is endowed by a mutation in an AUX/IAA gene”, PNAS, vol. 115, No. 13, pp. E2911-E2920, 2018. [cited by applicant]