IP Library › Granted Patent US 12,195,502
Granted Patent B2
US 12,195,502 · App. 17/312,484 · Granted Jan 14, 2025

Protein, and therapeutic and cosmetic uses thereof

Inventors: Nicholas T. Monsul (Sarasota, FL); Eva A. Berkes (Sarasota, FL); Frederick T. Boehm (Sarasota, FL); Yu-Hsien Liao (Sarasota, FL)
Assignee: QUORUM INNOVATIONS, LLC
C07K14/335A61P31/04C12N15/70
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Quick Facts
Patent No.
US 12,195,502
App. No.
17/312,484
Granted
Jan 14, 2025
Kind
B2
Abstract

The present invention provides a novel protein and biologically-active fragments and variants thereof with advantageous therapeutic and cosmetic uses. Also provided are methods of using the proteins, as well as methods of producing the proteins using a recombinant cell. Further provided are recombinant host cells transformed with a polynucleotide sequence that encodes the expression of the proteins.

Claims (4)

1. A method for treating dry eye disease or Meibomian gland dysfunction, wherein said method comprises administering, to a subject in need of such treatment, a therapeutically-effective amount of an isolated protein, or a cell expressing said protein, wherein the protein comprises SEQ ID NO: 1.

2. The method of claim 1 , used to treat dry eye disease.

3. The method of claim 1 , wherein the protein consists of SEQ ID NO: 1.

4. The method of claim 1 , used to treat Meibomian gland dysfunction.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 13, 2025
From: QUORUM INNOVATIONS, LLC
To: QUORUM INNOVATIONS, INC.
Reel/Frame 072547/0227 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 28, 2021
From: MONSUL, NICHOLAS T.; BERKES, EVA A.; BOEHM, FREDERICK T.; LIAO, YU-HSIEN
To: QUORUM INNOVATIONS, LLC
Reel/Frame 057006/0122 →
Continuity (2)
Provisional Application 63020860 · May 6, 2020
Related Publication 20230357332A1 · Nov 9, 2023
References Cited (15)
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WO 2017015275A1 · 2017 [cited by applicant]
Hypothetical protein BKD34_08830 [Limosilactobacillus fermentum], 2 pages, provided with Sep. 20, 2021 IDS, Oct. 2016 (Year: 2016). [cited by examiner]
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Yotpanya, P., et al., “Draft genome sequence of Lactobacillus fermentum 47-7, a probiotic strain isolated from healthy infants.” Genbank: AOY86567.1 hypothetical protein BKD34_08830 [Limosilactobacillus fermentum]. [cited by applicant]
Subhadra, B., et al., “Draft Whole-Genome Sequence of Lactobacillus Fermentum LfQi6, Derived from the Human Microbiome.” Genome Announcements, 2015, 3(3): e00423-15, pp. 1-2. [cited by applicant]
Database UniProt [Online] May 26, 2009 (May 26, 2009), “SubName: Full=Uncharacterized protein {ECO:0000313IEMBL:EEI22862.1 };” retrieved from EBI accession No. UniProt:COWVN8 Database accession No. COWVN8. [cited by applicant]
Database UniProt [Online] Jan. 18, 2017 (Jan. 18, 2017), “SubName: Full=Uncharacterized protein {ECO:0000313IEMBL:AOR74302.1 };” retrieved from EBI accession No. UniProt:A0A1 D7ZWV9 Database accession No. A0A 1 D7ZWV9. [cited by applicant]