PHARMACEUTICAL COMPOSITIONS COMPRISING POH DERIVATIVES
The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative. For example, the perillyl alcohol derivative may be a perillyl alcohol carbamate. The perillyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as cancer, comprising the step of delivering to a patient a therapeutically effective amount of a derivative of monoterpene (or sesquiterpene). The route of administration may vary, and can include, inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.
1 . A method for treating a disease in a mammal, the method comprising administering to the mammal a therapeutically effective amount of a pharmaceutical composition comprising octadeca-9, 12-dienoic acid 4-isopropenyl-cylcohex-1-enylmethyl ester (linoleoyl ester of POH) and at least one pharmaceutically acceptable carrier or diluent.
2 . The method of claim 2 , wherein the pharmaceutical composition is administered before, during or after radiation treatment.
3 . The method of claim 2 , further comprising administering to the mammal a chemotherapeutic agent.
4 . The method of claim 2 , wherein the pharmaceutical composition is administered by topical application.
5 . The method of claim 2 , wherein the disease is cancer.
6 . The method of claim 5 , wherein the cancer is selected from the group consisting of: lung cancer, ear, nose and throat cancer, leukemia, colon cancer, melanoma, pancreatic cancer, mammary cancer, prostate cancer, breast cancer, hematopoietic cancer, ovarian cancer, basal cell carcinoma, biliary tract cancer; bladder cancer; bone cancer; breast cancer; cervical cancer; choriocarcinoma; colon and rectum cancer; connective tissue cancer; cancer of the digestive system; endometrial cancer; esophageal cancer; eye cancer; cancer of the head and neck; gastric cancer; intra-epithelial neoplasm; kidney cancer; larynx cancer; leukemia including acute myeloid leukemia, acute lymphoid leukemia, chronic myeloid leukemia, chronic lymphoid leukemia; liver cancer; lymphoma including Hodgkin's and Non-Hodgkin's lymphoma; myeloma; fibroma, neuroblastoma; oral cavity cancer (e.g., lip, tongue, mouth, and pharynx); ovarian cancer; pancreatic cancer; prostate cancer; retinoblastoma; rhabdomyosarcoma; rectal cancer; renal cancer; cancer of the respiratory system; sarcoma; skin cancer; stomach cancer; testicular cancer; thyroid cancer; uterine cancer; cancer of the urinary system; and combinations thereof.
7 . A method for treating a disease in a mammal, comprising the step of delivering to the mammal pharmaceutical composition comprising hexadecanoic acid 4-isopropenyl-cylcohex-1-enylmethyl ester (palmitoyl ester of POH) having the chemical formula:
and at least one pharmaceutically acceptable carrier or diluent.
8 . The method of claim 7 , further comprising delivering to the mammal a chemotherapeutic agent.
9 . The method of claim 7 , wherein the pharmaceutical composition is administered by topical application.
10 . The method of claim 7 , wherein the disease is cancer.
11 . The method of claim 10 , wherein the cancer is selected from the group consisting of: lung cancer, ear, nose and throat cancer, leukemia, colon cancer, melanoma, pancreatic cancer, mammary cancer, prostate cancer, breast cancer, hematopoietic cancer, ovarian cancer, basal cell carcinoma, biliary tract cancer; bladder cancer; bone cancer; breast cancer; cervical cancer; choriocarcinoma; colon and rectum cancer; connective tissue cancer; cancer of the digestive system; endometrial cancer; esophageal cancer; eye cancer; cancer of the head and neck; gastric cancer; intra-epithelial neoplasm; kidney cancer; larynx cancer; leukemia including acute myeloid leukemia, acute lymphoid leukemia, chronic myeloid leukemia, chronic lymphoid leukemia; liver cancer; lymphoma including Hodgkin's and Non-Hodgkin's lymphoma; myeloma; fibroma, neuroblastoma; oral cavity cancer (e.g., lip, tongue, mouth, and pharynx); ovarian cancer; pancreatic cancer; prostate cancer; retinoblastoma; rhabdomyosarcoma; rectal cancer; renal cancer; cancer of the respiratory system; sarcoma; skin cancer; stomach cancer; testicular cancer; thyroid cancer; uterine cancer; cancer of the urinary system; and combinations thereof.