Stimulation design for neuromodulation
The present application relates to a new stimulation design which can be utilized to treat neurological conditions. The stimulation system produces a burst mode stimulation which alters the neuronal activity of the predetermined site, thereby treating the neurological condition or disorder. The burst stimulus comprises a plurality of groups of spike pulses having a maximum inter-spike interval of 100 milliseconds. The burst stimulus is separated by a substantially quiescent period of time between the plurality of groups of spike pulses. This inter-group interval may comprise a minimum of 5 seconds.
1. A method of stimulating nerve tissue of a patient to treat a neurological disorder using an implantable pulse generator, the method comprising:
generating, by the implantable pulse generator, a burst stimulus that comprises a plurality of groups of pulses with a quiescent period between each group in the plurality of groups, wherein:
(i) each group of pulses begins and ends at a reference amplitude level,
(ii) the burst stimulus is maintained at or above an amplitude level greater than the reference amplitude level between pulses within a respective group of the plurality of pulses,
(iii) each pulse within each group is separated by an inter-pulse interval of between 0.5 to 100 milliseconds, and
(iv) each group is separated by an inter-group interval of between 5 milliseconds and 5 seconds;
providing the burst stimulus from the implantable pulse generator to a medical lead; and
applying the burst stimulus to the nerve tissue of the patient via one or several electrodes of the medical lead.
2. The method of claim 1 further comprising: controlling the inter-pulse interval according to a parameter stored in the implantable pulse generator.
3. The method of claim 1 further comprising: controlling the inter-group interval according to a parameter stored in the implantable pulse generator.
4. The method of claim 1 further comprising: controlling a number of groups within the burst stimulus according to a parameter stored in the implantable pulse generator.
5. The method of claim 1 further comprising: generating a hyperpolarizing pulse immediately before each group of pulses within the burst stimulus.
6. The method of claim 5 wherein an amplitude of the hyperpolarizing pulse is controlled by a parameter stored in the implantable pulse generator.
7. The method of claim 1 further comprising: detecting, by the implantable pulse generator, hyperactivity within neural tissue using a sensor in the implantable pulse generator, wherein the generating the burst stimulus occurs in response to the detecting.
8. The method of claim 7 wherein the sensor is coupled to one or several electrodes of the medical lead.
9. The method of claim 1 , wherein the neurological disorder is at least one of chronic pain, hypertension, heart rhythm disorders, sleep apnea, depression, obsessive-compulsive disorder, obesity, Parkinson's, epilepsy, tinnitus, phantom pain, dystonia or chorea.
10. The method of claim 1 , wherein the nerve tissue is peripheral nerve tissue.
11. The method of claim 1 wherein the nerve tissue is brain tissue, spinal cord tissue, or brainstem tissue.
12. A system to treat a neurological disorder, comprising:
a medical lead having one or several electrodes configured to be located proximate to nerve tissue of a patient;
a pulse generator;
memory configured to instructions;
one or more processors that, when executing the instructions, are configured to:
cause the pulse generator to generate a burst stimulus that comprises a plurality of groups of pulses with a quiescent period between each group in the plurality of groups, wherein:
(i) each group of pulses begins and ends at a reference amplitude level,
(ii) the burst stimulus is maintained at or above an amplitude level greater than the reference amplitude level between pulses within a respective group of the plurality of pulses,
(iii) each pulse within each group is separated by an inter-pulse interval of between 0.5 to 100 milliseconds, and
(iv) each group is separated by an inter-group interval of between 5 milliseconds and 5 seconds; and
provide the burst stimulus from the pulse generator to the one or several electrodes of the medical lead.
13. The system of claim 12 wherein the one or more processors are further configured to control a number of pulses within a group of pulses of the burst stimulus according to a parameter stored in the memory.
14. The system of claim 12 wherein the one or more processors are further configured to control a maximum pulse amplitude according to a parameter stored in the memory.
15. The system of claim 12 wherein the one or more processors are further configured to control the inter-pulse interval according to a parameter stored in the memory.
16. The system of claim 12 wherein the one or more processors are further configured to control the inter-group interval according to a parameter stored in the memory.
17. The system of claim 12 wherein the one or more processors are further configured to cause the pulse generator to generate a hyperpolarizing pulse immediately before each group of pulses within the burst stimulus.
18. The system of claim 17 wherein an amplitude of the hyperpolarizing pulse is controlled by a parameter stored in the implantable pulse generator.
19. The system of claim 12 wherein the one or more processors are further configured to detect hyperactivity using a sensor in the implantable pulse generator, and to direct the pulse generator to generate the burst stimulus in response to the hyperactivity detected.
20. The system of claim 12 , wherein the neurological disorder is at least one of chronic pain, hypertension, heart rhythm disorders, sleep apnea, depression, obsessive-compulsive disorder, obesity, Parkinson's, epilepsy, tinnitus, phantom pain, dystonia or chorea.