Lipids and lipid nanoparticle formulations for delivery of nucleic acids
Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R 1 , R 2 , R 3 , L 1 , L 2 , G 1 , G 2 and G 3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
1. A compound having the following structure:
or a stereoisomer or pharmaceutically acceptable salt thereof.
2. A lipid nanoparticle comprising the compound of claim 1 .
3. The lipid nanoparticle of claim 2 , further comprising a messenger RNA.
4. A pharmaceutical composition comprising the compound of claim 1 and one or more pharmaceutically acceptable carriers, diluents or excipients.
5. A pharmaceutical composition comprising the lipid nanoparticle of claim 2 and one or more pharmaceutically acceptable carriers, diluents or excipients.
6. A pharmaceutical composition comprising the lipid nanoparticle of claim 3 and one or more pharmaceutically acceptable carriers, diluents or excipients.