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Provided herein is an ophthalmic composition formulated in deuterated water. Also disclosed herein are methods of treating, ameliorating, or reducing ophthalmic conditions or diseases by administering to an eye of an individual in need thereof an effective amount of an ophthalmic composition as described herein.
1. A method of treating an ophthalmic condition or disease comprising administering an ophthalmic composition to a subject in need thereof, the ophthalmic composition comprising:
(i) about 0.015 wt % to about 1 wt % pilocarpine or a pharmaceutically acceptable salt of pilocarpine, and
ii deuterated water, wherein the ophthalmic composition comprises at least 95% deuterated water;
wherein the composition comprises a pD of about 4 to about 8; wherein the composition comprises at least about 80% pilocarpine based on initial concentration after at least about one week under storage conditions.
2. The method of claim 1 , wherein the ophthalmic composition comprises at least one of: about 85%, about 90%, about 95%, about 97%, about 98%, or about 99% of the pilocarpine or the pharmaceutically acceptable salt of pilocarpine based on an initial concentration after an extended period of time under a storage condition, wherein the extended period of time is one of: about 1 week, about 2 weeks, about 3 weeks, about 1 month, about 2 months, about 3 months, about 4 months, about 5 months, about 6 months, about 8 months, about 10 months, about 12 months, about 18 months, about 24 months, about 36 months, about 4 years, or about 5 years.
3. The method of claim 2 , wherein the storage condition has a storage temperature of about 16° C. to about 30° C. or about 20° C. to about 25° C.
4. The method of claim 1 , wherein the ophthalmic composition comprises about 0.015 wt % to about 0.1 wt % of pilocarpine or a pharmaceutically acceptable salt of pilocarpine.
5. The method of claim 1 , wherein the ophthalmic composition further comprises ethylenediaminetetraacetic acid (EDTA).
6. The method of claim 1 , wherein the ophthalmic composition further comprises an osmolarity adjusting agent, a preservative, a buffering agent, a tonicity adjusting agent, a pD adjusting agent, a viscosity-enhancing agent, or a combination thereof.
7. The method of claim 6 , wherein the osmolarity adjusting agent is sodium chloride.
8. The method of claim 6 , wherein the preservative is selected from benzalkonium chloride, cetrimonium, sodium perborate, stabilized oxychloro complex, polyquaternium-1, chlorobutanol, edetate disodium, polyhexamethylene biguanide, or combinations thereof.
9. The method of claim 6 , wherein the buffering agent is selected from borates, borate-polyol complexes, phosphate buffering agents, citrate buffering agents, acetate buffering agents, carbonate buffering agents, organic buffering agents, amino acid buffering agents, or combinations thereof.
10. The method of claim 1 , wherein the ophthalmic composition has a pD of one of: about 4.5 to about 7.5, about 5 to about 7.0, or about 6 to about 7.0.
11. The method of claim 1 , wherein the ophthalmic composition is stored below room temperature prior to first use or is stored at between about 2° C. to about 10° C. prior to first use.
12. The method of claim 1 , wherein the ophthalmic composition is stored below room temperature after first use, is stored at between about 2° C. to about 10° C. after first use, or is stored at between about 16° C. to about 26° C. after first use.
13. The method of claim 1 , wherein the ophthalmic composition comprises less than 5% H 2 O.
14. A method of treating an ophthalmic condition or disease comprising administering an ophthalmic composition to a subject in need thereof, the ophthalmic composition comprising:
(i) about 0.015 wt. % to about 1 wt. % pilocarpine or a pharmaceutically acceptable salt of pilocarpine, tropicamide or a pharmaceutically acceptable salt of tropicamide, and
(ii) deuterated water, wherein the ophthalmic composition comprises at least 95% deuterated water;
wherein the composition comprises a pD of about 4 to about 8; wherein the composition comprises at least about 80% pilocarpine based on initial concentration after at least about one week under storage conditions.
15. The method of claim 14 , wherein the tropicamide or the pharmaceutically acceptable salt of tropicamide is present in the ophthalmic composition at a concentration about 0.001 wt % to about 20 wt %, about 0.010 wt % to about 0.1 wt %, or about 0.025 wt % to about 0.1 wt % of the total weight of the ophthalmic composition.
16. The method of claim 14 , wherein the tropicamide or the pharmaceutically acceptable salt of tropicamide is present in the ophthalmic composition at a concentration of at least about 0.02 wt %, 0.5 wt %, or 1.0 wt % of the total weight of the ophthalmic composition.
17. The method of claim 14 , wherein the ophthalmic composition further comprises an osmolarity adjusting agent, a preservative, a buffering agent, a tonicity adjusting agent, a pD adjusting agent, a viscosity-enhancing agent, or a combination thereof.
18. The method of claim 14 , wherein the ophthalmic composition is stored below room temperature prior to first use or is stored at between about 2° C. to about 10° C. prior to first use.
19. The method of claim 14 , wherein the ophthalmic composition is stored below room temperature after first use, is stored at between about 2° C. to about 10° C. after first use, or is stored at between about 16° C. to about 26° C. after first use.
20. The method of claim 1 , wherein the ophthalmic composition further comprises a preservative, a buffering agent, and an osmolarity adjusting agent.