Functionalized superabsorbent material for use in lesion phantom
Contrast targets for medical imaging are disclosed herein which include a granule of superabsorbent polymer (SAP) material. The granule of SAP material has absorbed and formed crosslinks with a hydrogen-containing liquid to form an expanded SAP particle with at least one predetermined medical imaging physical property.
1 . A medical imaging phantom, comprising:
a plurality of contrast targets, each contrast target of the plurality of contrast targets comprising an expanded superabsorbent polymer (SAP) sphere comprised of SAP material crosslinked with water or alcohol, the expanded SAP sphere having a predetermined size between 0.1 mm and 50 mm diameter; and
a background material surrounding the plurality of contrast targets, wherein the background material is a tissue-mimicking gel.
2 . The medical imaging phantom of claim 1 , wherein the plurality of contrast targets comprises a first portion of contrast targets of the plurality of contrast targets and a second portion of contrast targets of the plurality of contrast targets, wherein the contrast targets of the first portion have at least one physical property different from at least one physical property of the contrast targets of the second portion.
3 . The medical imaging phantom of claim 1 , wherein the plurality of contrast targets are present in the background material at a concentration of between 10%-80% by volume.
4 . The medical imaging phantom of claim 3 , wherein the plurality of contrast targets are present in the background material at the concentration of between 20%-80% by volume.
5 . The medical imaging phantom of claim 1 , wherein the plurality of contrast targets are randomly distributed within the background material.
6 . The medical imaging phantom of claim 5 , wherein the plurality of contrast targets are present in the background material at a concentration of between 20%-80% by volume.
7 . The medical imaging phantom of claim 1 , wherein the SAP material of the expanded SAP spheres has also absorbed and formed crosslinks with the other of water or alcohol.
8 . The medical imaging phantom of claim 1 , wherein the water or alcohol is a solution that comprises the water or alcohol and at least one additive material to achieve the predetermined size of the expanded SAP sphere.
9 . The medical imaging phantom of claim 8 , wherein the additive material is sodium chloride.
10 . The medical imaging phantom of claim 8 , wherein the additive material is a compound that comprises at least one of sodium, calcium, potassium, or iodine.
11 . The medical imaging phantom of claim 8 , wherein the at least one additive material comprises a first additive material and a second additive material, wherein the first additive material is different from the second additive material.
12 . The medical imaging phantom of claim 1 , wherein the plurality of contrast targets are between 1 mm-4 mm in diameter.
13 . The medical imaging phantom of claim 2 , wherein the medical imaging phantom is configured for use as a phantom for at least one of ultrasound, computed tomography (CT), magnetic resonance imaging (MRI), or photoacoustic imaging.
14 . The medical imaging phantom of claim 1 , wherein the medical imaging phantom is an ultrasound phantom and the contrast targets are anechoic.
15 . The medical imaging phantom of claim 1 , wherein the medical imaging phantom is an ultrasound phantom and the contrast targets have a different echogenicity than the background material.
16 . The medical imaging phantoms of claim 1 , wherein the medical imaging phantom is an ultrasound phantom and the contrast targets are hypoechoic or hyperechoic.
17 . A medical imaging phantom, comprising:
a plurality of contrast targets, each contrast target of the plurality of contrast targets comprising an expanded superabsorbent polymer (SAP) sphere comprised of SAP material crosslinked with water or alcohol, the expanded SAP sphere having a predetermined size between 0.1 mm and 50 mm diameter; and
a background material surrounding the plurality of contrast targets;
wherein the background material comprises a plurality of expanded SAP spheres comprised of SAP material crosslinked with water or alcohol, wherein the plurality of expanded SAP spheres of the background material have at least one physical property different from a physical property of the expanded SAP spheres of the plurality of contrast targets.
18 . A medical imaging phantom, comprising:
a plurality of contrast targets, each contrast target of the plurality of contrast targets comprising an expanded superabsorbent polymer (SAP) sphere comprised of SAP material crosslinked with water or alcohol, the expanded SAP sphere having a predetermined size between 0.1 mm and 50 mm diameter;
a background material surrounding the plurality of contrast targets; and
a solid container wherein the background material and the plurality of contrast targets are held within the solid container.
19 . A method of constructing a medical imaging phantom, the method comprising:
exposing granules of superabsorbent polymer (SAP) material to water or alcohol; forming expanded SAP spheres by absorbing the water or alcohol into the granules of SAP material to form crosslinks between the hydrogen-containing liquid and the SAP material;
selecting the expanded SAP spheres based upon size;
locating the expanded SAP spheres within a background material of tissue-mimicking gel.
20 . The method of claim 19 , further comprising:
sorting the granules of SAP material by at least one of shape or size; and
selecting a portion of the granules of SAP material for exposure to the water or alcohol based upon the sorting.
21 . The method of claim 19 , wherein locating the expanded SAP particles comprises providing the expanded SAP particles in a random distribution in the background material at a concentration of 10%-80% by volume.