System and method for non-invasive monitoring of hemoglobin

1. A system comprising:

a medical device comprising:

one or more light sources configured to provide incident light to patient tissue at a first excitation wavelength and a second excitation wavelength; and

a photodetector configured to:

monitor emissions in response to the first excitation wavelength at an emission wavelength; and

monitor emissions in response to the second excitation wavelength at the emission wavelength; and

one or more processors configured to determine a hemoglobin concentration level based on a ratio of emissions at the emission wavelength monitored in response to the first excitation wavelength and emissions at the emission wavelength monitored in response to the second excitation wavelength.

2. The system of claim 1 , wherein the hemoglobin concentration level is an oxyhemoglobin concentration level, wherein the emission wavelength is selected to correspond with a maximum of an oxyhemoglobin emission response to the first excitation wavelength and a minimum of the oxyhemoglobin emission response to the second excitation wavelength.

3. The system of claim 1 , wherein the hemoglobin concentration level is a de-oxyhemoglobin concentration level, wherein the emission wavelength is selected to correspond with a maximum of a de-oxyhemoglobin emission response to the first excitation wavelength and a minimum of the de-oxyhemoglobin emission response to the second excitation wavelength.

4. The system of claim 1 , wherein the one or more processors are configured to:

determine that the hemoglobin concentration level has fallen below a threshold value; and

generate an alert in response to the determination that the hemoglobin concentration level has fallen below the threshold value.

5. The system of claim 4 , wherein the alert indicates anemia.

6. The system of claim 1 , wherein the one or more processors are configured to:

determine a plurality of hemoglobin concentration levels over time during a monitoring period; and

provide an output indicating a trend in hemoglobin concentration levels over the monitoring period.

7. The system of claim 1 ,

wherein the medical device comprises one or more sensors configured to sense one or more of an electrocardiogram (ECG) signal, respiration rate, bio-impedance level, activity level, posture, or temperature of the patient, and

wherein the one or more processors are configured to determine a patient condition based on the hemoglobin concentration level and the one or more of the ECG signal, respiration rate, bio-impedance level, activity level, posture, or temperature.

8. The system of claim 1 , wherein the medical device is configured for implantation within the patient.

9. The system of claim 1 , wherein the medical device comprises the one or more processors.

10. The system of claim 1 , further comprising a remote monitoring center comprising the one or more processors.

11. A system comprising:

a medical device comprising:

at least one light source configured to provide incident light to patient tissue;

a first photodetector configured to monitor an emission response at a first emission wavelength, wherein the first emission wavelength is selected to correspond with a maximum of the emission response of oxyhemoglobin;

a second photodetector configured to monitor the emission response at a second emission wavelength, wherein the second emission wavelength is selected to correspond with an isosbestic point of the emission response of oxyhemoglobin and the emission response of de-oxyhemoglobin; and

a third photodetector configured to monitor the emission response at a third emission wavelength, wherein the third emission wavelength is selected to correspond with a maximum of the emission response of de-oxyhemoglobin; and

one or more processors configured to:

receive the emission responses at the first emission wavelength, the second emission wavelength, and the third emission wavelength;

calculate a first ratio based on the received emission responses at the first wavelength and the second wavelength, wherein the first ratio is expressed as a numerator divided by a denominator;

calculate a second ratio based on the received emission responses at the third wavelength and the second wavelength, wherein the second ratio is expressed as a numerator divided by a denominator; and

determine a hemoglobin concentration level based on a combination of the first ratio and the second ratio.

12. The system of claim 11 , wherein the one or more processors are configured to:

determine that the hemoglobin concentration level has fallen below a threshold value; and

generate an alert in response to the determination that the hemoglobin concentration level has fallen below the threshold value.

13. The system of claim 11 , wherein the one or more processors are configured to:

determine a plurality of hemoglobin concentration levels over time during a monitoring period; and

provide an output indicating a trend in hemoglobin concentration levels over the monitoring period.

14. A method performed by a medical device comprising processing circuitry and being configured to determine a hemoglobin concentration level, the method comprising:

providing incident light, by one or more light sources of the medical device, to patient tissue at a first excitation wavelength;

monitoring emissions, by one or more photodetectors of the medical device, in response to the first excitation wavelength at an emission wavelength;

providing incident light, by the one or more light sources, to the patient tissue at a second excitation wavelength;

monitoring emissions, by the one or more photodetectors, in response to the second excitation wavelength at the emission wavelength; and

determining, by the processing circuitry, a hemoglobin concentration level based on a ratio of emissions at the emission wavelength monitored in response to the first excitation wavelength and emissions at the emission wavelength monitored in response to the second excitation wavelength.

15. The method of claim 14 , wherein the hemoglobin concentration level is an oxyhemoglobin concentration level, and wherein the emission wavelength is selected to correspond with a maximum of an oxyhemoglobin emission response to the first excitation wavelength and a minimum of the oxyhemoglobin emission response to the second excitation wavelength.

16. The method of claim 14 , wherein the hemoglobin concentration level is a de-oxyhemoglobin concentration level, and wherein the emission wavelength is selected to correspond with a maximum of a de-oxyhemoglobin emission response to the first excitation wavelength and a minimum of the de-oxyhemoglobin emission response to the second excitation wavelength.

17. The method of claim 14 , further comprising:

determining, by the processing circuitry, that the hemoglobin concentration level has fallen below a threshold value; and

generating, by the processing circuitry, an alert in response to the determination that the hemoglobin concentration level has fallen below the threshold value.

18. The method of claim 17 , wherein the generating of the alert comprises generating an alert of anemia.

19. The method of claim 14 , wherein the determining of the hemoglobin concentration level comprises determining a plurality of hemoglobin concentration levels over time during a monitoring period, the method further comprising providing an output, by the processing circuitry, indicating a trend in hemoglobin concentration levels over the monitoring period.

20. The method of claim 14 , further comprising:

sensing, by the medical device, one or more of an electrocardiogram (ECG) signal, respiration rate, bio-impedance level, activity level, posture, or temperature of the patient; and

determining, by the processing circuitry, a patient condition based on the hemoglobin concentration level and the one or more of the ECG signal, respiration rate, bio-impedance level, activity level, posture, or temperature.