Intrasacular Aneurysm Occlusion Device with a Flexible Net or Mesh and Polymer Longitudinal Embolic Members
This invention is an intrasaccular aneurysm occlusion device with a flexible net or mesh which is deployed into an aneurysm sac and then expanded by the insertion of polymer longitudinal embolic members (e.g. polymer tubular strands) into the net or mesh. As the net or mesh expands, it comes into contact with the walls of the aneurysm sac and conforms to the shape of even an irregularly-shaped aneurysm sac.
1 . An intrasacular device to occlude an aneurysm comprising:
a flexible and expandable net or mesh which is configured to be inserted into an aneurysm sac; and
one or more polymer longitudinal embolic members which are inserted into the net or mesh after the net or mesh has been inserted into the aneurysm sac, wherein accumulation of the embolic members in the net or mesh causes the net or mesh to expand, come into contact with the interior walls of the aneurysm sac, and conform to the shape of the interior walls of the aneurysm sac.
2 . The device in claim 1 wherein the embolic members are tubular polymer strands and/or soft polymer coils.
3 . The device in claim 1 wherein the embolic members are made from made from one or more materials selected from the group consisting of: cellulose acetate, cellulose acetate butyrate, cellulose acetate phthalate, carboxymethyl cellulose, cellulose ester, cellulose propionate, cellulose triacetate, ethyl cellulose, hydroxybutyl methyl cellulose, methyl cellulose, hydroxypropyl cellulose, and nitrocellulose.
4 . The device in claim 1 wherein the embolic members are made from one or more materials selected from the group consisting of: polyvinyl alcohol, polyvinyl chloride, polyvinyl ester, polyvinyl halide, polyvinyl pyrrolidone, polyvinyl acetate, polyvinyl phenol, and polyvinyl pyrrolidone.
5 . The device in claim 1 wherein the embolic members are made from one or more materials selected from the group consisting of: PEG (poly-ethylene-glycol), PMMA (poly-methyl-meth-acrylate), PLGA (poly-glycolic-acid), and PEEK (poly-ether-ether-ketone).
6 . The device in claim 1 wherein the embolic members are made from one or more materials selected from the group consisting of: chitin and collagen.
7 . The device in claim 1 wherein the embolic members are made from hydrogel.
8 . The device in claim 1 wherein a longitudinal segment of a polymer longitudinal embolic member is detached by cutting after the segment has been inserted into the net or mesh.
9 . The device in claim 1 wherein a longitudinal segment of a polymer longitudinal embolic member is detached by cutting by a moving sharp edge after the segment has been inserted into the net or mesh.
10 . The device in claim 1 wherein a longitudinal segment of a polymer longitudinal embolic member is detached by cutting by a laser after the segment has been inserted into the net or mesh.
11 . The device in claim 1 wherein there is a closeable proximal opening in the net or mesh, wherein the longitudinal embolic members are inserted through the proximal opening into the net or mesh after the net or mesh has been inserted into the aneurysm sac, and wherein the proximal opening is closed after the longitudinal embolic members have been inserted into the net or mesh.
12 . The device in claim 1 wherein there is a closeable proximal opening in the net or mesh, wherein the longitudinal embolic members are inserted through the proximal opening into the net or mesh after the net or mesh has been inserted into the aneurysm sac, and wherein the proximal opening is closed by the device operator after the longitudinal embolic members have been inserted into the net or mesh.
13 . The device in claim 1 wherein there is a closeable proximal opening in the net or mesh, wherein the closeable opening, when open, has a diameter that is at least 25% greater than the cross-sectional diameter of the longitudinal embolic members, wherein the longitudinal embolic members are inserted through the opening into the net or mesh after the net or mesh has been inserted into the aneurysm sac, and wherein the opening is closed after the longitudinal embolic members have been inserted into the net or mesh.
14 . The device in claim 1 wherein a proximal portion of the net or mesh has a first level of porosity, a distal portion of the net or mesh has a second level of porosity, and the second level is greater than the first level.
15 . The device in claim 1 wherein a proximal portion of the net or mesh has a first level of flexibility, elasticity, and/or malleability, a distal portion of the net or mesh has a second level of flexibility, elasticity, and/or malleability, and the second level is greater than the first level.
16 . The device in claim 1 wherein a proximal portion of the net or mesh is composed of material with a first percentage of metal, up to 100%, a distal portion of the net or mesh is composed of material with a second percentage of metal, and the second percentage is less than the first percentage.
17 . The device in claim 1 wherein the device further comprises an intrasacular neck bridge which is configured to be inserted into the aneurysm sac and self-expand to span the interior of the aneurysm neck, wherein the neck-bridge is closer to the aneurysm neck than the net or mesh.
18 . The device in claim 17 wherein the intrasacular neck bridge is attached to the net or mesh.
19 . The device in claim 17 wherein the intrasacular neck bridge is inside the net or mesh.
20 . The device in claim 17 wherein the intrasacular neck bridge is outside the net or mesh.