IP Library Granted Patent US 12,186,340
Granted Patent B2
US 12,186,340 · App. 17/358,929 · Granted Jan 7, 2025

Synthetic antimicrobial mineral compositions, methods of making and using same

Inventors: Keith David Morrison (Livermore, CA); Gabriela G. Loots (Oakland, CA); Ty James Samo (Walnut Creek, CA); Kelly Anne Martin (Dublin, CA)
Assignee: LAWRENCE LIVERMORE NATIONAL SECURITY, LLC
A61K33/26A61L15/18A61L15/44B33Y70/10B33Y80/00C08L83/04
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Quick Facts
Patent No.
US 12,186,340
App. No.
17/358,929
Granted
Jan 7, 2025
Kind
B2
Abstract

Provided herein are pharmaceutical compositions comprising a Fe 2+ -exchanged fluorinated synthetic smectite and a synthetic semiconducting metal sulfide. The compositions can be used to treat topical conditions and gastrointestinal ailments, and can be incorporated into wound dressings, hydrogels, personal protective equipment, and 3D printed articles. Also provided are methods of synthesizing the Fe 2+ -exchanged fluorinated synthetic smectite and methods of making the synthetic semiconducting metal sulfide.

Claims (21)

1. A pharmaceutical composition comprising Fe 2+ -exchanged fluorinated synthetic smectite and synthetic semiconducting metal sulfide, wherein the Fe 2+ -exchanged fluorinated synthetic smectite comprises interlayer Fe 2+ , and when administered the interlayer Fe 2+ is released from interlayer spaces of the Fe 2+ -exchanged fluorinated synthetic smectite.

2. The composition of claim 1 , wherein the Fe 2+ -exchanged fluorinated synthetic smectite is present in an amount of 80 wt % to 98.5 wt %, based on the total weight of the composition and wherein the synthetic semiconducting metal sulfide is present in an amount of 1.5 wt % to 20 wt % based on the total weight of the composition.

3. The composition of claim 2 , wherein the Fe 2+ -exchanged fluorinated synthetic smectite is produced by exchange of a fluorinated synthetic smectite with 5 mM to 60 mM of a ferrous iron source.

4. The composition of claim 1 , wherein the Fe 2+ -exchanged fluorinated synthetic smectite, at an octahedral site, comprises Li + .

5. The composition of claim 1 , wherein the Fe 2+ -exchanged fluorinated synthetic smectite, at an octahedral site, comprises Mg 2+ , Cu 2+ , Zn 2+ , or Fe 2+ .

6. The composition of claim 1 , wherein the Fe 2+ -exchanged fluorinated synthetic smectite comprises from 5 meq to 100 meq of ferrous iron (Fe 2+ ), per 100 g of the Fe 2+ -exchanged fluorinated synthetic smectite.

7. The composition of claim 1 , free of arsenic, lead, cobalt, nickel, mercury, or uranium.

8. The composition of claim 1 , wherein the semiconducting metal sulfide comprises one or more of synthetic pyrite, synthetic acanthite, synthetic chalcocite, synthetic bornite, synthetic sphalerite, synthetic chalcopyrite, and synthetic marcasite.

9. The composition of claim 1 , wherein the semiconducting metal sulfide is present in amount of 5 wt % to 20 wt % based on the total weight of the composition.

10. The composition of claim 9 , wherein the Fe 2+ -exchanged fluorinated synthetic smectite is produced by exchange of a fluorinated synthetic smectite with 20 mM to 150 mM of a ferrous iron source.

11. A wound dressing comprising the composition of claim 1 suspended in a hydrogel.

12. An article of personal protective equipment comprising the composition of claim 1 .

13. A 3D-printed article comprising the composition of claim 1 and a siloxane resin.

14. A method of treating an infection, comprising administering the pharmaceutical composition of claim 1 to a subject in need thereof.

15. The method of claim 14 , wherein the composition is administered orally or topically.

16. The method of claim 14 , wherein upon administration, the composition maintains an Eh value of about 400 mV to about 900 mv for at least 24 hours.

17. The method of claim 14 , wherein the infection is a topical infection.

18. The method of any one of claims 17 , wherein the topical infection is a bacterial infection, a fungal infection, or acne.

19. The method of claim 14 , wherein the infection is a gastrointestinal infection.

20. The method of claim 19 , wherein the gastrointestinal infection is dysentery.

21. The method of claim 14 , wherein the infection is a bacterial infection comprising antibiotic resistant bacteria, and the antibiotic resistant bacteria is selected from the group consisting of Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumonia, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter, Escherichia coli , extended-spectrum beta lactamase positive (ESBL) Escherichia coli, Salmonella enterica serotype typhimurium , a methicillin-resistant Staphylococcus aureus (MRSA), Staphylococcus epidermidis , methicillin-resistant Staphylococcus epidermidis (MRSE), Propionibacterium acnes, Clostridiodies difficile, Listeria monocytogenes, Pasteurella multocida, Proteus vulgaris, Bacillus cereus, Bordetella bronchiseptica , and any combination thereof.

Assignments (2)
CONFIRMATORY LICENSE Recorded Aug 27, 2021
From: LAWRENCE LIVERMORE NATIONAL SECURITY, LLC.
To: U.S. DEPARTMENT OF ENERGY
Reel/Frame 057336/0459 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 7, 2021
From: MORRISON, KEITH DAVID; LOOTS, GABRIELA G.; SAMO, TY JAMES; MARTIN, KELLY ANNE
To: LAWRENCE LIVERMORE NATIONAL SECURITY, LLC
Reel/Frame 056781/0494 →
Continuity (2)
Provisional Application 63044639 · Jun 26, 2020
Related Publication 20220000912A1 · Jan 6, 2022
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