IP Library Granted Patent US 11,672,508
Granted Patent B2
US 11,672,508 · App. 17/372,182 · Granted Jun 13, 2023

System and method for shear wave elastography by transmitting ultrasound with subgroups of ultrasound transducer elements

Inventors: James F. Greenleaf (Rochester, MN); Shigao Chen (Rochester, MN); Pengfei Song (Champaign, IL); Armando Manduca (Rochester, MN)
Assignee: Mayo Foundation for Medical Education and Research
A61B8/485A61B8/08A61B8/4488A61B8/4494A61B8/5223G01N29/07G01N29/262G01S7/5209G01S7/52022G01S7/52042G01S15/8915G01S15/8927G01N2291/011G01N2291/02475G01N2291/02827G01N2291/0422
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Quick Facts
Patent No.
US 11,672,508
App. No.
17/372,182
Granted
Jun 13, 2023
Kind
B2
Abstract

Systems and methods for performing shear wave elastography using push and/or detection ultrasound beams that are generated by subsets of the available number of transducer elements in an ultrasound transducer. These techniques provide several advantages over currently available approaches to shear wave elastography, including the ability to use a standard, low frame rate ultrasound imaging system and the ability to measure shear wave speed throughout the entire field-of-view rather than only those regions where the push beams are not generated.

Claims (24)

1. A method for measuring a mechanical property of an object using an ultrasound system having an ultrasound transducer that includes a plurality of transducer elements, the steps of the method comprising:

a) controlling the ultrasound transducer to energize a plurality of subgroups of transducer elements so as to transmit a corresponding plurality of different focused ultrasound beams each focused at one of a plurality of different lateral locations, wherein the plurality of different focused ultrasound beams extend outward from the ultrasound transducer in a comb-shaped pattern;

b) obtaining elastography data representative of the multiple different shear waves by transmitting at least one detection ultrasound beam into the object and receiving echo signals in response thereto;

c) generating processed elastography data by processing the obtained elastography data to separate the multiple different shear waves into multiple different directional components to reduce effects of interference between the multiple different shear waves; and

d) calculating a mechanical property of the object using the processed elastography data.

2. The method of claim 1 , wherein:

the plurality of subgroups of transducer elements comprises a first plurality of subgroups of transducer elements and a second plurality of subgroups of transducer elements,

the comb-shaped pattern comprises a first comb-shaped pattern associated with the first plurality of subgroups of transducer elements and a second comb-shaped pattern associated with the second plurality of subgroups of transducer elements; and

step a) comprises:

controlling the ultrasound transducer to energize a first plurality of subgroups of transducer elements so as to transmit a corresponding first plurality of different focused ultrasound beams each focused at one of the plurality of different lateral locations, wherein the first plurality of different focused ultrasound beams extend outward from the ultrasound transducer in a first comb-shaped pattern; and

controlling the ultrasound transducer to energize a second plurality of subgroups of transducer elements so as to transmit a corresponding second plurality of different focused ultrasound beams each focused at one of the plurality of different lateral locations, wherein the second plurality of different focused ultrasound beams extend outward from the ultrasound transducer in a second comb-shaped pattern.

3. The method as recited in claim 2 , wherein at least some of the first plurality of different focused ultrasound beams and second plurality of different focused ultrasound beams are generated by spatially adjacent subgroups of transducer elements.

4. The method as recited in claim 2 , wherein at least some of the first plurality of different focused ultrasound beams and second plurality of different focused ultrasound beams are generated by spatially overlapping subgroups of transducer elements.

5. The method as recited in claim 1 , wherein step b) includes:

i) dividing the transducer elements in the ultrasound transducer into a plurality of subgroups of transducer elements;

ii) successively transmitting a set of ultrasound beams using a different subgroup of transducer elements, thereby successively transmitting ultrasound to different regions in the object;

iii) repeating step ii) at a pulse repetition frequency such that each set of ultrasound beams is effectively repeated at the pulse repetition frequency.

6. The method as recited in claim 1 , wherein step c) includes applying a directional filter to the elastography data.

7. The method as recited in claim 1 , wherein step a) includes transmitting at least some of the plurality of different focused ultrasound beams to focus at different depth locations than other ones of the plurality of different focused ultrasound beams.

8. The method as recited in claim 1 , wherein calculating the mechanical property in step d) includes using at least one of a time-to-peak method, a cross-correlation method, a direct inversion method, and a frequency dependent analysis method.

9. The method as recited in claim 1 , wherein at least some of the plurality of different focused ultrasound beams are transmitted for a longer duration than others of the plurality of different focused ultrasound beams.

10. The method as recited in claim 1 , wherein some of the plurality of subgroups of transducer elements include more transducer elements than others of the plurality of subgroups of transducer elements.

11. The method of claim 1 , wherein the plurality of different focused ultrasound beams are focused at lateral locations in a first region in the object and the elastography data are obtained from a second region that is different from the first region.

12. The method of claim 11 , wherein the second region comprises lateral locations that are adjacent the first region.

Assignments (2)
CONFIRMATORY LICENSE Recorded Dec 6, 2023
From: MAYO CLINIC ROCHESTER
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 065789/0281 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 12, 2021
From: GREENLEAF, JAMES F.; CHEN, SHIGAO; SONG, PENGFEI; MANDUCA, ARMANDO
To: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
Reel/Frame 056817/0525 →
Continuity (4)
Continuation 16023782 · Jun 29, 2018
Division 14397395
Provisional Application 61710744 · Oct 7, 2012
Related Publication 20210338205A1 · Nov 4, 2021