Rho kinase inhibitor BA-1049 (R) and active metabolites thereof
BA-1049 (R) and its active metabolite are disclosed. Also disclosed are pharmaceutical formulations containing BA-1049 (R) or its active metabolite.
1. A method for treating cerebral cavernous malformations (CCM) in a patient in need thereof, the method comprising:
administering to the patient a therapeutically effective amount of a pharmaceutical formulation comprising an adipate salt of a crystalline form of a compound of structure:
wherein the crystalline form is characterized by an X-ray powder diffraction (XRPD) spectrum having a peak expressed in degrees 2θ (±0.2) of about 12.2.
2. The method of claim 1 , wherein the compound is deuterated.
3. The method of claim 1 , wherein the pharmaceutical formulation further comprises at least one additional rho kinase inhibitor.
4. The method of claim 1 , further comprising:
administering to the patient a second pharmaceutical formulation comprising a therapeutically effective amount of an additional rho kinase inhibitor.
5. The method of claim 1 , wherein the adipate salt of the compound is in a crystalline form.
6. A crystalline form of an adipate salt of a compound of Formula I, having the structure:
wherein the crystalline form is characterized by an X-ray powder diffraction (XRPD) spectrum having a peak expressed in degrees 2θ (±0.2) of about 12.2.
7. The crystalline form of claim 5 , wherein the crystalline form is characterized by an X-ray powder diffraction (XRPD) spectrum that is substantially equivalent to FIG. 27 .
8. The crystalline form of claim 5 , wherein the crystalline form is characterized by an X-ray powder diffraction (XRPD) spectrum having a peak expressed in degrees 2θ (±0.2) of about 12.2, about 15.9, and about 19.8.
9. The crystalline form of claim 5 , wherein the crystalline form is characterized by an X-ray powder diffraction (XRPD) spectrum having a peak expressed in degrees 2θ (±0.2) of about 4, about 6, about 12.2, about 15.9, and about 19.8.
10. A method for treating a patient having a neurological condition, the method comprising:
administering a pharmaceutical composition which comprises one or more of a therapeutically effective amount of a crystalline form of the adipate salt of a compound of Formula I, a therapeutically effective amount of a compound of Formula II, or combinations thereof; wherein the crystalline form is characterized by an X-ray powder diffraction (XRPD) spectrum having a peak expressed in degrees 2θ (±0.2) of about 12.2
11. The method of claim 10 , wherein the neurological condition is selected from cerebral cavernous malformation, stroke, cerebral aneurysm, cerebral aneurysm stroke, spinal cord injury, spinal cord injury stroke, traumatic brain injury, optic nerve injury, peripheral nerve injury, vasospasm after subarachnoid hemorrhage, hereditary hemorrhagic telangiectasis, cerebral arteriovascular malformations, or combinations thereof.
12. The method of claim 10 , wherein the pharmaceutical formulation further comprises a pharmaceutically acceptable carrier.
13. The method of claim 10 , wherein the pharmaceutical formulation further comprises a therapeutically effective amount of a rho kinase inhibitor which is not the compound of Formula I or the compound of Formula II.
14. The method of claim 10 , wherein the compound of Formula I and/or the compound of Formula II is deuterated.