IP Library Granted Patent US 12,121,503
Granted Patent B2
US 12,121,503 · App. 17/382,219 · Granted Oct 22, 2024

Antiviral treatments

Inventors: Yarlagadda S Babu (Birmingham, AL); Pooran Chand (Birmingham, AL); Shanta Bantia (Birmingham, AL); Shane Arnold (Hoover, AL); John Michael Kilpatrick (Helena, AL)
Assignee: BIOCRYST PHARMACEUTICALS, INC.
A61K31/215A61K9/0019A61K9/006A61K31/195A61K31/196A61K45/06
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Quick Facts
Patent No.
US 12,121,503
App. No.
17/382,219
Granted
Oct 22, 2024
Kind
B2
Abstract

The invention provides unit dosage forms, kits, and methods useful for treating viral infections.

Claims (18)

1. A method for treating an influenza viral infection in a human comprising administering in multiple intravenous administrations for up to 20 days, the multiple intravenous administrations providing an effective anti-viral amount of from 500 mg to 1,000 mg of a compound of formula I or formula Ia:

or a pharmaceutically acceptable salt thereof, to the human, wherein the influenza viral infection is a seasonal influenza viral infection.

2. The method of claim 1 , wherein the compound of formula I is a compound of formula Ia:

or a pharmaceutically acceptable salt thereof.

3. The method of claim 1 , wherein the effective anti-viral amount is 500 mg.

4. The method of claim 1 , wherein the effective anti-viral amount is 1000 mg.

5. The method of claim 1 , wherein the effective anti-viral amount is 600 mg.

6. The method of claim 1 , further comprising orally administering a neuraminidase inhibitor to the human.

7. The method of claim 6 , wherein the neuraminidase inhibitor that is administered orally is oseltamivir carboxylate.

8. The method of claim 6 , wherein the neuraminidase inhibitor that is administered orally is a compound of formula I, II, III, or IV:

or a pharmaceutically acceptable salt thereof.

9. The method of claim 6 , wherein the neuraminidase inhibitor that is administered orally is a compound of formula Ia, IIa, IIIa, or IVa:

or a pharmaceutically acceptable salt thereof.

10. The method of claim 6 , wherein the neuraminidase inhibitor that is administered orally is a compound of formula Ia,

or a pharmaceutically acceptable salt thereof.

11. The method of claim 6 , wherein the neuraminidase inhibitor that is administered orally is administered for up to 20 days.

12. The method of claim 6 , wherein the neuraminidase inhibitor that is administered orally is administered for up to 10 days.

13. The method of claim 6 , wherein the neuraminidase inhibitor that is administered orally is administered for up to 5 days.

Assignments (2)
SECURITY INTEREST Recorded Jan 23, 2026
From: BIOCRYST PHARMACEUTICALS, INC.
To: WILMINGTON TRUST, NATIONAL ASSOCIATION
Reel/Frame 074485/0651 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 28, 2023
From: BABU, YARLAGADDA SUDHAKARA; CHAND, POORAN; BANTIA, SHANTA; ARNOLD, SHANE; KILPATRICK, JOHN MICHAEL
To: BIOCRYST PHARMACEUTICALS, INC.
Reel/Frame 065067/0406 →
Continuity (7)
Continuation 16533283 · Aug 6, 2019
Continuation 15714918 · Sep 25, 2017
Continuation 14313738 · Jun 24, 2014
Continuation 13103562 · May 9, 2011
Division 11705546 · Feb 12, 2007
Provisional Application 60772748 · Feb 13, 2006
Related Publication 20220040137A1 · Feb 10, 2022