Mussel adhesive protein-based photothermal agent and photothermal-responsive adhesive nanoparticles
The present invention relates to: a photothermal agent which includes a mussel adhesive protein; and photothermal-responsive nanoparticles that generate a biocompatible gas by means of light and heat and release a drug. Nanoparticles according to the present invention exhibit a photothermal effect when near-infrared rays are applied thereto, and may be applied to trimodality therapy in which a biocompatible gas is generated by means of light and heat to induce the release of a drug.
1. Photothermal-responsive adhesive nanoparticles comprising
a mussel adhesive protein consisting of the amino acid sequence of SEQ ID NO: 9,
S-nitrosoglutathione as a photothermal-responsive gas donor, and
VCl 3 as a transition metal halide.
2. The photothermal-responsive adhesive nanoparticles of claim 1 , wherein the mussel adhesive protein is characterized in that 10 to 100% of the total tyrosine residues are modified into DOPA.
3. The photothermal-responsive adhesive nanoparticles of claim 1 , further comprising doxorubicin as an anti-cancer drug.
4. The photothermal-responsive adhesive nanoparticles of claim 1 , wherein the gas is nitric oxide.