CELL PROCESSING DEVICE CELL PROCESSING SYSTEM AND METHODS OF USE THEREOF
A cell processing device for use in performing one or more unit processes in one or more of cell or gene therapy manufacturing, comprising a cell processing platform fluidly coupled to at least one auxiliary container and to at least one primary container, the cell processing platform comprising a body portion comprising at least one fluid inlet fluidly connected to a fluid outlet, and an auxiliary container port fluidly coupled to the at least one fluid inlet of the body portion, wherein the at least one auxiliary container is received in sealing engagement with the auxiliary container port such that the auxiliary container lumen is fluidly connected with the at least one fluid inlet of the body portion, and a primary container is received in sealingly engagement with the primary container port such that the primary container lumen is fluidly connected with the fluid outlet of the body portion.
1 . A cell processing device for use in performing one or more unit processes in one or more of cell or gene therapy manufacturing, comprising:
a cell processing platform fluidly coupled to at least one auxiliary container and to at least one primary container, the cell processing platform comprising a body portion comprising at least one fluid inlet fluidly connected to a fluid outlet; and
an auxiliary container port fluidly coupled to the at least one fluid inlet of the body portion,
wherein the at least one auxiliary container is received in sealing engagement with the auxiliary container port to fluidly connect the auxiliary container lumen with the at least one fluid inlet of the body portion, and a primary container is received in sealingly engagement with the primary container port to fluidly connect the primary container lumen with the fluid outlet of the body portion.
2 . The cell processing device according to claim 1 , wherein the auxiliary container port comprises a container receiving sleeve connected to the body portion and being configured to surround at least a portion of the auxiliary container, which portion comprises the fluid outlet of the container.
3 . The cell processing device according to claim 1 , wherein the cell processing platform comprises a plurality of auxiliary container ports and wherein each one of a plurality of auxiliary containers are received in sealing engagement with one of the plurality of auxiliary container ports to fluidly couple the lumen of each auxiliary container is fluidly coupled with a fluid inlet of the body portion.
4 . The cell processing device according to claim 3 , wherein each auxiliary container port is coupled to a separate fluid inlet of the body portion.
5 . The cell processing device according to claim 4 , wherein each separate fluid inlet of the body portion is fluidly connected to a fluid outlet of the body portion.
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17 . The cell processing device according to claim 1 , wherein the auxiliary container port comprises a sterile connector end at one or more of the fluid inlet or the fluid outlet of the auxiliary container port, each sterile connector end configured to engage with a further sterile connector end on a container or on the body portion, respectively.
18 . The cell processing device according to claim 1 , wherein the fluid outlet of the body portion comprises a sterile connector end configured to engage with a further sterile connector end on the primary container attachable to the body portion.
19 . The cell processing device according to claim 1 , comprising at least one positional tracking device operable to indicate a set location on the platform.
20 . The cell processing device according to claim 19 , wherein the positional tracking device is one or more of: a magnet, an RFID sensor, a light sensor or a cog operable to engage a further cog.
21 . (canceled)
22 . (canceled)
23 . A cell processing device according to claim 19 , wherein the at least one positional tracking device is located on the body portion relative to the auxiliary container port.
24 . (canceled)
25 . The cell processing device according to claim 1 , comprising a sampling port in the body portion.
26 . The cell processing device according to claim 1 , comprising a gas transfer port in the body portion.
27 . The cell processing device according to claim 1 , wherein the auxiliary container port is configured to receive an auxiliary container having a base section, a top section arranged substantially in parallel with the base section and a wall element arranged between the top section and the base section and defining an internal lumen of the container, in which the wall element of the container preferably is compressible with respect to the top and base section and the wall element of the container is composed of a flexible material.
28 . The cell processing device according to claim 1 , wherein the primary container port is configured to receive a primary container having a base section, a top section arranged substantially in parallel with the base section and a wall element arranged between the top section and the base section and defining an internal lumen of the container, in which the wall element of the container preferably is compressible with respect to the top and base section and the wall element of the container is composed of a flexible material.
29 . The cell processing device according to claim 28 , wherein the primary container further comprises an attachment flange mounted to the top section of the primary container and being configured to sealingly engage and mount to the primary container port.
30 . The cell processing device according to claim 1 , wherein, the at least one auxiliary container is compressible.
31 . The cell processing device according to claim 1 , wherein the at least one auxiliary container is one of: a syringe or any shaped container with a moving seal allowing variable volume operations.
32 . The cell processing device according to claim 1 , wherein the at least one auxiliary container is a bag retained in a frame and moveable with respect to the frame.
33 . The cell processing device according to claim 1 , comprising one or more auxiliary containers detachably connected to an auxiliary container port of the cell processing platform.
34 . The cell processing device according to claim 33 , wherein one or more of the auxiliary containers are connected to a respective auxiliary container port with a sterile connector.
35 . (canceled)
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