CELL PROCESSING PLATFORM CELL PROCESSING SYSTEM AND METHODS OF USE THEREOF
The present disclosure relates to a cell processing platform for use in one or more unit operations in cell and/or gene therapy manufacture, the platform comprising a body portion comprising at least one fluid inlet fluidly connected to a fluid outlet, and an auxiliary container port fluidly coupled to the at least one fluid inlet of the body portion, wherein the auxiliary container port is configured and arranged to receive and sealingly engage with an auxiliary container and to fluidly connect the auxiliary container lumen with the at least one fluid inlet of the body portion, and a primary container port configured and arranged to sealingly engage with a primary container and to fluidly connect the primary container lumen with the fluid outlet of the body portion.
1 . A cell processing platform for use in one or more unit operations in cell and/or gene therapy manufacture, the platform comprising a body portion comprising at least one fluid inlet fluidly connected to a fluid outlet, and an auxiliary container port fluidly coupled to the at least one fluid inlet of the body portion, wherein the auxiliary container port is configured and arranged to receive and sealingly engage with an auxiliary container and to fluidly connect an auxiliary container lumen with the at least one fluid inlet of the body portion, and a primary container port configured and arranged to sealingly engage with a primary container and to fluidly connect the primary container lumen with the fluid outlet of the body portion.
2 . The cell processing platform of claim 1 , wherein the auxiliary container port comprises a container receiving sleeve connected to the body portion and being configured to surround at least a portion of the auxiliary container which, which portion comprises the fluid outlet of the container.
3 . The cell processing platform of claim 1 , wherein the auxiliary container port comprises a mating element configured to fluidly connect to a corresponding mating element on an auxiliary container.
4 . The cell processing platform of claim 3 , wherein the mating element is at least one of: a sterile connector end or a LUER-LOK™.
5 . The cell processing platform of claim 1 , wherein the primary container port comprises a mating element configured to fluidly connect to a corresponding mating element on a primary container.
6 . The cell processing platform of claim 5 , wherein the mating element comprises at least one of: a sterile connector end or a LUER-LOK™.
7 . The cell processing platform of claim 1 , wherein the auxiliary container port comprises a sterile connector end at the fluid inlet and/or the fluid outlet of the auxiliary container port, each sterile connector end configured to engage with a further sterile connector end on a container and/or on the body portion, respectively.
8 . The cell processing platform of claim 1 , wherein the fluid outlet of the body portion comprises a sterile connector end configured to engage with a further sterile connector end on a primary container attachable to the body portion.
9 . (canceled)
10 . The cell processing platform of claim 1 , wherein the at least one fluid inlet and the fluid outlet of the body portion are fluidly coupled to one another by a fluid conduit.
11 .- 16 . (canceled)
17 . The cell processing platform of claim 1 , comprising a plurality of auxiliary container ports each configured and arranged to receive and sealingly engage with an auxiliary container and to fluidly connect the container lumen with a fluid inlet of the body portion.
18 . The cell processing platform of claim 17 , wherein each auxiliary container port is coupled to a separate fluid inlet of the body portion.
19 . The cell processing platform of claim 18 , wherein each separate fluid inlet of the body portion is fluidly connected to a fluid outlet of the body portion.
20 . The cell processing platform of claim 1 , comprising at least one positional tracking device that indicates a set location on the platform.
21 . (canceled)
22 . (canceled)
23 . The cell processing platform of claim 20 , wherein the at least one positional tracking device is located relative to the auxiliary container port such that the location of the positional tracking device is related to the position of the auxiliary container port.
24 . (canceled)
25 . The cell processing platform of claim 1 , comprising a sampling port in the body portion.
26 . The cell processing platform of claim 1 , comprising a gas transfer port in the body portion.
27 . The cell processing platform of claim 1 , wherein the auxiliary container port is configured to receive a container having a base section, a top section arranged substantially in parallel with the base section and a wall element arranged between the top section and the base section and defining an internal lumen of the container, in which the wall element of the container preferably is compressible with respect to the top and base section and the wall element of the container is composed of a flexible material.
28 . The cell processing platform of claim 1 , wherein the primary container port is configured to receive a primary container having a base section, a top section arranged substantially in parallel with the base section and a wall element arranged between the top section and the base section and defining an internal lumen of the container, in which the wall element of the container preferably is compressible with respect to the top and base section and the wall element of the container is composed of a flexible material.
29 . The cell processing platform of claim 28 , wherein the primary container further comprises an attachment flange mounted to the top section of the primary container and being configured to sealingly engage and detachably mount to the primary container port.