METHODS OF INTRODUCING FOOD ALLERGENS
Methods for introducing allergens to a human subject are provided.
1 . A method for introducing allergens to a human subject for the treatment or prevention of food allergies, the method comprising administering to the subject two or more allergenic units, wherein the initial administration of each allergenic unit is staggered, each allergenic unit is administered daily, every other day, every 2 or 3 days, or weekly, the initial administration of each additional allergenic unit is at least two days after the initial administration of a previously administered allergenic unit, and each previously administered allergenic unit continues to be administered in addition to each additional allergenic unit as each additional allergenic unit is administered; and
wherein each allergenic unit comprises a different food allergen selected from the group consisting of: an allergenic unit comprising least one tree nut selected from the group consisting of almond, cashew, walnut, pecan, hazelnut, and pistachio; an allergenic unit comprising a white fish and/or a pink fish; and an allergenic unit comprising shellfish.
2 . A method for introducing allergens to a human subject comprising administering to the subject:
a first allergenic unit comprising about 30 mg of peanut protein and optionally Vitamin D; wherein the first allergenic unit is administered daily, every other day, every 2 or 3 days, or weekly.
3 . The method of claim 2 , further comprising administering to the subject a second allergenic unit comprising about 30 mg of soy protein, wherein the second allergenic unit is administered at least about 2 days after the first allergenic unit is first administered, and wherein the second allergenic unit is administered daily, every other day, every 2 or 3 days or weekly.
4 . The method of claim 3 , further comprising administering to the subject a third allergenic unit comprising about 30 mg of egg protein, wherein the third allergenic unit is administered at least about 2 days after the second allergenic unit is first administered, and wherein the third allergenic unit is administered daily, every other day, every 2 or 3 days or weekly.
5 . The method of claim 4 , further comprising administering to the subject a fourth allergenic unit comprising about 30 mg of milk protein, wherein the fourth allergenic unit is administered at least about 2 days after the third allergenic unit is first administered, and wherein the fourth allergenic unit is administered daily, every other day, every 2 or 3 days or weekly.
6 . The method of claim 5 , further comprising administering to the subject a fifth allergenic unit comprising about 30 mg each of almond protein, cashew protein, walnut protein, pecan protein, hazelnut protein and pistachio protein, wherein the fifth allergenic unit is administered at least about 2 days after the fourth allergenic unit is first administered, and wherein the fifth allergenic unit is administered daily, every other day, every 2 or 3 days or weekly.
7 . The method of claim 6 , further comprising administering to the subject a sixth allergenic unit comprising about 30 mg each of salmon protein and cod protein, wherein the sixth allergenic unit is administered at least about 2 days after the fifth allergenic unit is first administered, and wherein the sixth allergenic unit is administered daily, every other day, every 2 or 3 days or weekly.
8 . The method of claim 7 , further comprising administering to the subject a seventh allergenic unit comprising about 30 mg of shrimp protein, wherein the seventh allergenic unit is administered at least about 2 days after the sixth allergenic unit is first administered, and wherein the seventh allergenic unit is administered daily, every other day, every 2 or 3 days or weekly.
9 . The method of claim 8 , further comprising administering to the subject an eighth allergenic unit comprising about 30 mg of sesame protein, wherein the eighth allergenic unit is administered at least about 2 days after the seventh allergenic unit is first administered, and wherein the eighth allergenic unit is administered daily, every other day, every 2 or 3 days or weekly.
10 . The method of claim 9 , further comprising administering to the subject a ninth allergenic unit comprising about 30 mg each of wheat protein and oat protein, wherein the ninth allergenic unit is administered at least about 2 days after the eighth allergenic unit is first administered, and wherein the ninth allergenic unit is administered daily, every other day, every 2 or 3 days or weekly.
11 . The method of claim 5 , further comprising administering to the subject a fifth allergenic unit comprising about 30 mg each of 1-6 tree nut proteins, wherein the fifth allergenic unit is administered at least about 2 days after the fourth allergenic unit is first administered, and wherein the fifth allergenic unit is administered daily, every other day, every 2 or 3 days or weekly.
12 . The method of claim 6 , further comprising administering to the subject a sixth allergenic unit comprising about 30 mg each of one, two or three fish proteins, wherein the sixth allergenic unit is administered at least about 2 days after the fifth allergenic unit is first administered, and wherein the sixth allergenic unit is administered daily, every other day, every 2 or 3 days or weekly.
13 . The method of claim 7 , further comprising administering to the subject a seventh allergenic unit comprising about 30 mg of a shellfish protein, wherein the seventh allergenic unit is administered at least about 2 days after the sixth allergenic unit is first administered, and wherein the seventh allergenic unit is administered daily, every other day, every 2 or 3 days or weekly.
14 . The method of claim 8 , further comprising administering to the subject an eighth allergenic unit comprising about 30 mg of sesame protein, wherein the eighth allergenic unit is administered at least about 2 days after the seventh allergenic unit is first administered, and wherein the eighth allergenic unit is administered daily, every other day, every 2 or 3 days or weekly.
15 . The method of claim 9 , further comprising administering to the subject a ninth allergenic unit comprising about 30 mg each of wheat protein and oat protein, wherein the ninth allergenic unit is administered at least about 2 days after the eighth allergenic unit is first administered, and wherein the ninth allergenic unit is administered daily, every other day, every 2 or 3 days or weekly.
16 . A method for introducing allergens to a human subject comprising administering to the subject:
a first allergenic unit comprising about 30 mg of peanut protein and optionally Vitamin D;
a second allergenic unit comprising about 30 mg of soy protein, wherein the second allergenic unit is administered at least about 2 days after the first allergenic unit is first administered,
a third allergenic unit comprising about 30 mg of egg protein, wherein the third allergenic unit is administered at least about 2 days after the second allergenic unit is first administered.
a fourth allergenic unit comprising about 30 mg of milk protein, wherein the fourth allergenic unit is administered at least about 2 days after the third allergenic unit is first administered;
a fifth allergenic unit comprising about 30 mg each of almond protein, cashew protein, walnut protein, pecan protein, hazelnut protein and pistachio protein, wherein the fifth allergenic unit is administered at least about 2 days after the fourth allergenic unit is first administered;
a sixth allergenic unit comprising about 30 mg each of salmon protein and cod protein, wherein the sixth allergenic unit is administered at least about 2 days after the fifth allergenic unit is first administered;
a seventh allergenic unit comprising about 30 mg of shrimp protein, wherein the seventh allergenic unit is administered at least about 2 days after the sixth allergenic unit is first administered,
an eighth allergenic unit comprising about 30 mg of sesame protein, wherein the eighth allergenic unit is administered at least about 2 days after the seventh allergenic unit is first administered; and
a ninth allergenic unit comprising about 30 mg each of wheat protein and oat protein, wherein the ninth allergenic unit is administered at least about 2 days after the eighth allergenic unit is first administered.
17 . A method for introducing allergens to a human subject comprising administering to the subject two or more allergenic units, wherein a first allergenic unit is administered daily and each additional allergenic unit is administered sequentially; wherein each allergenic unit is selected from the group consisting of:
an allergenic unit comprising about 30 mg by protein weight of peanut and optionally Vitamin D;
an allergenic unit comprising about 30 mg by protein weight of soy;
an allergenic unit comprising about 30 mg by protein weight of egg;
an allergenic unit comprising about 30 mg by protein weight of milk;
an allergenic unit comprising about 30 mg by protein weight each of at least one tree nut selected from the group consisting of almond, cashew, walnut, pecan, hazelnut, and pistachio;
an allergenic unit comprising about 30 mg by protein weight each of salmon and cod;
an allergenic unit comprising about 30 mg by protein weight of shrimp;
an allergenic unit comprising about 30 mg by protein weight of sesame; and
an allergenic unit comprising about 30 mg by protein weight of at least one of wheat and oat;
wherein each selected allergenic unit is administered after at least two days of administration of a previously selected allergenic unit.
18 . A kit comprising:
a first unit comprising one allergenic component selected from the group consisting of: peanut, tree nut, cow's milk, soy, egg, fish and shellfish; and optionally Vitamin D;
a second unit comprising a first subunit and a second subunit, wherein the first subunit comprises the same allergenic component as the first unit, and the second subunit comprises one allergenic component selected from the group consisting of: peanut, tree nut, cow's milk, soy, egg, fish and shellfish; and optionally Vitamin D, wherein the second subunit allergenic component is different than the first subunit allergenic component; and wherein the first subunit and second subunit may be separate or combined.
19 . The kit of claim 18 , further comprising one or more sequential additional units, where each additional unit comprises a first additional subunit and a second additional subunit, wherein the first additional subunit comprises the same allergenic components as the previous unit, and the second additional subunit comprises one allergenic component selected from the group consisting of: peanut, tree nut, cow's milk, soy, egg, fish and shellfish; and optionally Vitamin D, wherein the second additional subunit allergenic component is different than any of the first additional subunit allergenic components; and wherein the first additional subunit and second additional subunit may be separate or combined.
20 . The kit of claim 18 or 19 , wherein the allergenic components are each about 30 mg protein.