Granted Patent B2

US 12,338,264 · App. 17/431,825 · Granted Jun 24, 2025

Inventors: Akiko Miyake (Okayama, JP); Osamu Sano (Okayama, JP); Hirofumi Kunitake (Okayama, JP)

Assignee: Nagase Viita Co., Ltd.

C07H17/04C07B2200/13

Abstract

Claims (12)

1. A crystalline potassium salt of 2-O-α-D-glucosyl-L-ascorbic acid.

2. The crystalline potassium salt of 2-O-α-D-glucosyl-L-ascorbic acid of claim 1 , which has at least diffraction peaks at diffraction angles (2θ) of 8.27°, 8.81°, 16.05°, 18.88°, and 25.64°, when measured by powder X-ray diffraction analysis.

3. The crystalline potassium salt of 2-O-α-D-glucosyl-L-ascorbic acid of claim 1 , which is in a hydrous crystalline form.

4. A method for producing the crystalline potassium salt of 2-O-α-D-glucosyl-L-ascorbic acid of claim 1 , comprising:

dissolving 2-O-α-D-glucosyl-L-ascorbic acid in a potassium hydroxide aqueous solution, wherein the molar ratio of potassium hydroxide to 2-O-α-D-glucosyl-L-ascorbic acid in the aqueous solution is 2.7 to 5.4;

adding an alcohol to the resulting solution such that the ratio of the alcohol to the 2-O-α-D-glucosyl-L-ascorbic acid is 3;

allowing the resulting mixture to stand; and

collecting the precipitated crystalline potassium salt of 2-O-α-D-glucosyl-L-ascorbic acid in the mixture.

5. The method of claim 4 , wherein said alcohol is methanol or ethanol.

6. A composition, which comprises the crystalline potassium salt of 2-O-α-D-glucosyl-L-ascorbic acid of claim 1 .

7. The composition of claim 6 , which further comprises an anhydrous crystalline 2-O-α-D-glucosyl-L-ascorbic acid, wherein the ratio of said anhydrous crystalline 2-O-α-D-glucosyl-L-ascorbic acid and said crystalline potassium salt of 2-O-α-D-glucosyl-L-ascorbic acid is in the range of 70:30 to 45:55 by mass.

8. The composition of claim 6 , which is in the form of food and beverage, cosmetic, pharmaceutical, quasi-drug, or industrial product.

Assignments (2)

Priority Claims (1)

Continuity (1)

References Cited (24)