Granted Patent
B2
US 12,728,181 · App. 17/437,280 · Granted Sep 8, 2026
Solution blow spun polymer constructs, compositions and methods of fabrications and uses relating thereto
Inventors:
John Daristotle (Bel Air, MD); Shadden Zaki (Bethesda, MD); Peter Kofinas (North Bethesda, MD); Anthony Sandler (Bethesda, MD); Lung Lau (Washingtron, DC); Leopoldo Torres (Greenbelt, MD)
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Abstract
The present disclosure relates to a biocompatible composition comprising a solution of low molecular weight polymer and high molecular weight polymer. The present disclosure also relates to biocompatible compositions comprising poly(lactic-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG), and additionally including a suspension of silica particles and/or a therapeutic agent. The present disclosure is also directed to biocompatible polymer fiber constructs formed from the disclosed compositions, methods of fabrication thereof, and uses of such constructs and compositions.
Claims (21)
1 . A composition comprising:
a solution comprising:
(i) between about 1% and about 20% weight per volume (w/v) low molecular weight (LMW) polymer; and (ii) between about 1% and about 20% (w/v) high molecular weight (HMW) polymer;
wherein said LMW polymer is PEG;
wherein said poly(ethylene glycol) (PEG) has a molecular weight of 950 to 1050 Da; and
wherein said HMW polymer has a molecular weight of about 10000 Da to about 42000 Da.
2 . The composition of claim 1 , wherein said HMW polymer is poly(lactide-co-caprolactone) (PLCL) or poly(lactide-co-glycolide) (PLGA).
3 . The composition of claim 1 , which, after sprayed and dried, yields a solid adhesive comprising a ratio of the LMW polymer to the HMW polymer ranging from 90:10 to 20:80 by weight.
4 . The composition of claim 3 , wherein the weight ratio of the LMW polymer to the HMW polymer of the solid adhesive is about 50:50 by weight.
5 . The composition of claim 3 , wherein the weight ratio of the LMW polymer to the HMW polymer of the solid adhesive is about 70:30 by weight.
6 . The composition of claim 1 , wherein said solution further comprises between about 0.01% and about 1% w/v therapeutic agent based on the volume of the solution, wherein said therapeutic agent is selected from the group consisting of a protein, a peptide, an amine, an aliphatic compound, and an antibiotic.
7 . The composition of claim 1 , wherein the solution comprises one or more volatile solvent(s).
8 . The composition of claim 1 , wherein said HMW polymer is poly(lactide-co-caprolactone) (PLCL).
9 . The composition of claim 8 , wherein said PLCL is present in a molecular weight of about 35000 Da.
10 . A biocompatible polymer fiber construct comprising blow spun polymer fibers formed from said composition of claim 1 .
11 . The construct of claim 10 , which is a tissue sealant, adhesive, hemostatic or scaffolding material.
12 . The construct of claim 10 , wherein said polymer fibers have an average diameter of between about 1 micrometer (μm) and about 12 μm.
13 . A method of forming a polymer fiber construct, comprising:
forming a plurality of polymer fibers using a solution blow spinning process, wherein said polymer fibers are formed from said composition of claim 1 ; and
depositing said plurality of blow spun polymer fibers onto a target to form a conformal polymer fiber construct thereon.
14 . The method of claim 13 , wherein said target is a tissue surface, said polymer fiber construct formed on said tissue surface in vivo.
Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Aug 20, 2025
From: LOTHSTEIN, LEONARD; SOBERMAN, JUDITH; SEAGROVES, TIFFANY N.
To: PARADOX PHARMACEUTICALS INC.
Reel/Frame 072067/0668 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Aug 14, 2025
From: SANDLER, ANTHONY; LAU, LUNG
To: CHILDREN'S NATIONAL MEDICAL CENTER
Reel/Frame 072018/0450 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jul 9, 2025
From: KOFINAS, PETER; DARISTOTLE, JOHN; TORRES, LEOPOLDO
To: UNIVERSITY OF MARYLAND, COLLEGE PARK
Reel/Frame 071645/0122 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded May 28, 2025
From: KOFINAS, PETER; DARISTOTLE, JOHN; ZAKI, SHADDEN
To: UNIVERSITY OF MARYLAND, COLLEGE PARK
Reel/Frame 071233/0924 →
Continuity (2)
Provisional Application
62816568
· Mar 11, 2019
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