Application for inhibitors of cAMP efflux in body care
The present invention is directed to previously identified inhibitors of cAMP efflux (ICE) and their use in treating/masking body odor, inhibiting, reducing and/or eliminating hyperhidrosis (excessive sweating), tanning skin or protecting skin before and/or after exposure to the sun as well as for treating certain skin conditions, in one embodiment, the invention provides a method for inhibiting body odor, a condition that is characterized by an unpleasant odor from the products of the microbial sweat degradation. By inhibiting the efflux of the precursor compounds that are degraded, novel compounds are capable of preventing unwanted odors. Deodorant compositions that employ this new approach for the control of bodily odor are provided, ICE compounds can also be used as components, of cosmetic formulations including tanning and after-sun formulations, formulations for skin conditions as described herein and other cosmetic formulations.
1. A method of treating body malodor and/or hyperhidrosis in a subject comprising administering to said subject a composition comprising an effective amount of a cAMP efflux inhibitor in combination with at least one additional cosmetic additive, wherein said cAMP efflux inhibitor is compound according to the chemical structure:
a pharmaceutically acceptable salt or stereoisomer thereof, or a mixture thereof; and said at least one cosmetic additive is water, an alcohol or other water compatible cosmetically acceptable solvent, a water incompatible solvent, an emollient, a humectant, an oil, a conditioning agent, a surfactant, a thickener/thickening agent, a stiffening agent, an emulsifier, a medicament, a fragrance, a preservative, a deodorant component, an antiperspirant compound, a skin protecting agent, a pigment, a dye, a coloring agent, a preservative or a mixture thereof.
2. The method according to claim 1 wherein said composition comprises at least one deodorant or antiperspirant compound.
3. The method according to claim 2 wherein said deodorant compound is triclosan or cyclomethicone and said antiperspirant compound is an aluminum salt.
4. The method according to claim 3 wherein said aluminum salt is aluminum chlorhydrate, aluminum formate, aluminum zirconium tetrachlorhydrex glycine or a mixture thereof.