IMPLANTABLE OCULAR DRUG DELIVERY DEVICES AND METHODS
An implantable ocular drug delivery system can include inserting an implantable device into an eye, where the device contains therapeutics intended to be released for local or systemic effects. In some implantable device embodiments, the device includes a microchannel intended to reduce intraocular pressure. In some implantable device embodiments, the device includes a microchannel intended to treat dry eye.
1 - 14 . (canceled)
15 . An implantable ocular drug delivery device, comprising:
a body having a distal end portion and a proximal end portion, the body having a longitudinal length sufficient to position the distal end portion in an anterior chamber of an eye and the proximal end portion in a tear film of the eye when the body is implanted in a sclera of the eye,
the body defining an internal chamber and an inlet to the internal chamber through an outer surface of the body, wherein the internal chamber is communicative to an exterior region around the body via the inlet; and
a pharmacological agent in the internal chamber.
16 . The device of claim 15 , the body defining a lumen extending between the distal end portion and the proximal end portion, the lumen providing fluid communication between the anterior chamber and the tear film when the body is implanted in the sclera of the eye.
17 . The device of claim 16 , wherein material of the body separates an entirety of the internal chamber from the lumen.
18 . The device of claim 15 , wherein the body defines one or more fenestrations.
19 . The device of claim 15 , wherein an inlet portion of the internal chamber has a smaller cross-sectional area than a remaining portion of the internal chamber that is located farther internally than the inlet portion.
20 . The device of claim 15 , wherein an inlet portion of the internal chamber has a larger cross-sectional area than a remaining portion of the internal chamber that is located farther internally than the inlet portion.
21 . The device of claim 15 , wherein the body defines one or more additional inlets to the internal chamber.
22 . The device of claim 15 , wherein the body defines one or more additional internal chambers and corresponding inlets to the one or more additional internal chambers.
23 . The device of claim 22 , wherein the pharmacological agent is a first pharmacological agent, wherein the device further comprises a second pharmacological agent in the one or more additional internal chambers, and wherein the first and second pharmacological agents are different types of pharmacological agents.
24 . The device of claim 15 , wherein the proximal end portion is laterally wider than the distal end portion.
25 . The device of claim 15 , wherein the proximal end portion comprises a crossbar tab that is a laterally wider than the distal end portion.
26 . The device of claim 15 , wherein the body comprises at least two barbs extending laterally from a mid-body portion of the body.
27 . The device of claim 15 , wherein the pharmacological agent comprises a polymeric matrix that includes poly(lactic acid), poly(glycolic acid), poly(lactide-co-glycolide), poly(anhydrides), poly(dioxanone), poly(amides), poly(hydroxy butyrate), polyester, poly(caprolactone), poly(adepic acid), poly(sebacic acid), poly(terpthalic acid), poly(amino acids), poly(glutamic acid), poly(imino carbonate), poly(phosphates), poly(phosphonates), poly(phosphazenes), poly(cyanoacrylates), poly(urethanes), poly(ortho ester), poly(acetals), poly(dimethylsiloxane), poly(urethane), poly(amido amines), poly(amide-enamines), poly(acrylates), poly(acrylamides), poly(carbophil), poly(acrylic acid), poly(ethylene-vinyl acetate), poly(vinyl alcohol), poly(enol-ketone), poly(ethylene), poly(propylene), poly(vinyl chloride), poly(ortho esters), poly(ether-ester), collagen, albumin, gelatin, alginate, cyclodextrin, chitosan, dextran, agarose, hyaluronic acid, starch, or cellulose.
28 . The device of claim 15 , wherein at least a portion of an external surface of the body is textured by laser engraving or plasma treatment.
29 . The device of claim 15 , wherein the body does not define a microchannel running through a length of the device.