IP Library Granted Patent US 12,201,433
Granted Patent B2
US 12,201,433 · App. 17/452,367 · Granted Jan 21, 2025

Detection and localization of myocardial infarction using vectorcardiography

Inventor: Alfonso Aranda Hernandez (Maastricht, NL)
Assignee: Medtronic, Inc.
A61B5/341A61B5/355A61B5/366G16H50/20G16H50/70
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,201,433
App. No.
17/452,367
Granted
Jan 21, 2025
Kind
B2
Abstract

A method includes detecting whether one or more myocardial infarctions (MI) has occurred using vectorcardiographic (VCG) signals with gradient boosting, the VCG signals including VCG loops, and determining an MI location using the VCG signals and gradient boosting.

Claims (32)

1. A method comprising:

detecting electrocardiogram (ECG) signals from a patient;

determining vectorcardiographic (VCG) signals as a function of the ECG signals, wherein the VCG signals comprise VCG loops;

extracting features from the VCG signals, wherein the extracted features comprise at least one of geometrical features of the VCG loops and/or spatio-temporal information of the VCG loops;

detecting, using one or more trained machine learning models, one or more myocardial infarctions (MI) based on the extracted features; and

determining, using the one or more trained machine learning models, an MI location of the detected one or more myocardial infarctions based on the extracted features.

2. The method of claim 1 , wherein determining the MI location includes identifying a region of a heart of where the one or more MI has occurred.

3. The method of claim 1 , wherein the geometrical features include one or more of loop perimeter, loop centroid, maximum vector length (MVL), loop area, Ratio Perimeter/Area, Maximum distance between centroid and VCG loop, Angle between MVL and the different planes, Angle between QRS and T wave maximum vectors, or Angle between QRS and T wave optimal planes.

4. The method of claim 1 , wherein the geometrical features of the VCG loops includes geometrical features of QRS VCG loops and T-wave VCG loops.

5. The method of claim 1 , wherein the spatio-temporal information includes one or more of octant average vector length, maximum vector length (MVL) per octant, percentage of time per octant, or variance of vector magnitude per octant.

6. The method of claim 1 , wherein the spatio-temporal information of the VCG loops includes spatio-temporal distribution information of the VCG loops for both QRS VCG loops and T-wave VCG loops.

7. The method of claim 1 , wherein the one or more trained machine learning models is trained using a gradient boosting method.

8. A system comprising:

a set of electrodes configured to sense electrocardiogram (ECG) signals; and

processing circuitry configured to:

determine vectorcardiographic (VCG) signals as a function of the ECG signals, wherein the VCG signal comprise CCG loops;

extract features from the VCG signals, wherein the extracted features comprise at least one of geometrical features of the VCG loops and/or spatio-temporal information of the VCG loops;

detect, using one or more trained machine learning models, one or more myocardial infarctions (MI) based on the extracted features; and

determine, using the one or more trained machine learning models, a MI location of the detected one or more myocardial infarctions based on the extracted features using the VCG signals and gradient boosting.

9. The system of claim 8 , wherein the determination of the MI location includes identification of a region of a heart of where the one or more MI has occurred.

10. The system of claim 8 , wherein the geometrical features include geometrical features of QRS VCG loops and T-wave VCG loops.

11. The system of claim 8 , wherein the geometrical features include one or more of loop perimeter, loop centroid, maximum vector length, loop area, Ratio Perimeter/Area, Maximum distance between centroid and VCG loop, Angle between MVL and the different planes, Angle between QRS and T wave maximum vectors, or Angle between QRS and T wave optimal planes.

12. The system of claim 8 , wherein the spatio-temporal information includes one or more of octant average vector length, maximum vector length (MVL) per octant, percentage of time per octant, or variance of vector magnitude per octant.

13. The system of claim 8 , wherein the spatio-temporal information of the VCG loops includes spatio-temporal distribution information of the VCG loops for both QRS VCG loops and T-wave VCG loops.

14. The system of claim 8 , wherein the one or more trained machine learning models is trained using a gradient boosting method.

15. A non-transitory computer-readable storage medium comprising instructions, that when executed, cause processing circuitry to:

receive electrocardiogram (ECG) signals from a patient;

determine vectorcardiographic (VCG) signals as a function of the ECG signals wherein the VCG signals comprise VCG loops;

extract features from the VCG signals wherein the extracted features comprise at least one of geometrical features of the VCG loops and/or spatio-temporal information of the VCG loops;

detect, using one or more trained machine learning models, one or more myocardial infarctions (MI) based on the extracted features; and

determine, using the one or more trained machine learning models, an MI location of the detected one or more myocardial infarctions based on the extracted features.

16. The non-transitory computer-readable storage medium of claim 15 , wherein the one or more trained machine learning models is trained using a gradient boosting method.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 26, 2021
From: ARANDA HERNANDEZ, ALFONSO
To: MEDTRONIC BAKKEN RESEARCH CENTER B.V.
Reel/Frame 057920/0369 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 26, 2021
From: MEDTRONIC BAKKEN RESEARCH CENTER B.V.
To: MEDTRONIC, INC.
Reel/Frame 057920/0404 →
Continuity (2)
Provisional Application 63106639 · Oct 28, 2020
Related Publication 20220125365A1 · Apr 28, 2022
References Cited (30)
US 7266408B2 · Bojovic · 2007 [cited by examiner]
US 10039468B2 · Gupta · 2018 [cited by examiner]
US 11311230B2 · Sullivan · 2022 [cited by examiner]
US 20160135706A1 · Sullivan · 2016 [cited by examiner]
US 20170340887A1 · Engels · 2017 [cited by examiner]
US 20190216350A1 · Sullivan et al. · 2019 [cited by applicant]
US 20220125365A1 · Aranda Hernandez · 2022 [cited by examiner]
Acharya et al., “Automated detection and localization of myocardial infarction using electrocardiogram: a comparative study of different leads”, Knowledge-Based Systems. vol. 99, Jan. 2016, pp. 146-156. [cited by applicant]
Aranda et al., “Performance of Dower's Inverse Transform and Frank Lead System for Identification of Myocardial Infarction”, 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (… [cited by applicant]
Bousseljot, “PTB Diagnostic ECG Database”, Sep. 25, 2004, 3 pp. Retrieved from the Internet: https://www.physionet.org/content/ptbdb/1.0.0/. [cited by applicant]
Chapelle et al. “Yahoo! Learning to Rank Challenge Overview”, JMLR: Workshop and Conference Proceedings 14, Jun. 2011, 24 pp. [cited by applicant]
Correa et al., “Novel set of vectorcardiographic parameters for the identification of ischemic patients”, Medical Engineering & Physics, Mar. 12, 2012, 13 pp. [cited by applicant]
Frank, “A Direct Experimental Study of Three Systems of Spatial Vectorcardiography”, American Heart Association Circulation, vol. X, Jul. 1954, pp. 101-113. [cited by applicant]
Frank, “An Accurate, Clinically Practical System for Spatial Vectorcardiography”, American Heart Association Circulation, vol. XIII, May 1956, pp. 737-749. [cited by applicant]
Friedman et al. “Additive Logistic Regression: A Statistical View of Boosting”, The Annals of Statistics, vol. 28, No. 2, Apr. 2000, pp. 337-407. [cited by applicant]
Friedman, “Stochastic gradient boosting”, Computational Statistics & Data Analysis 38, 2002 (Applicant points out, in accordance with MPEP 609.04(a), that the year of publication, 2002, is sufficiently earlier than the … [cited by applicant]
Goldberger et al. “PhysioBank, PhysioToolkit, and PhysioNet: components of a new research resource for complex physiologic signals”, American Heart Association Circulation, vol. 101, No. 23, Jun. 13, 2000, 6 pp. [cited by applicant]
Han et al., “Automated interpretable detection of myocardial infarction fusing energy entropy and morphological features”, Computer Methods and Programs in Biomedicine, vol. 175, Jul. 2019, pp. 9-23. [cited by applicant]
Hernandez et al., “Myocardial Ischemia Diagnosis Using a Reduced Lead System”, 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Jul. 2018, 4 pp. [cited by applicant]
Hernandez, “Automated detection and localization of myocardial infarction using vectorcardiography”, Journal of Knowledge-Based Systems, Jul. 24, 2020, 29 pp. [cited by applicant]
International Search Report and Written Opinion of International Application No. PCT/US2021/072087, dated Feb. 9, 2022, 11 pp. [cited by applicant]
Liu et al., “MFB-CBRNN: A Hybrid Network for MI Detection Using 12-Lead ECGs”, IEEE Journal of Biomedical and Health Informatics, vol. 24, Issue 2, Feb. 2020, pp. 503-514. [cited by applicant]
Mathers et al., “WHO methods and data sources for country-level causes of death 2000-2016”, Department of Information, Evidence and Research WHO, Mar. 2018, 65 pp. [cited by applicant]
Reasat et al. “Detection of Inferior Myocardial Infarction using Shallow Convolutional Neural Networks”, 2017 IEEE Region 10 Humanitarian Technology Conference (R10-HTC), Dec. 21-23, 2017, pp. 718-721. [cited by applicant]
Ridgeway, “Generalized Boosted Models: A guide to the gbm package”, Aug. 3, 2007, 12 pp. [cited by applicant]
Thygesen et al., “Third universal definition of myocardial infarction”, European Heart Journal—Expert Consensus Document, Aug. 24, 2012, 18 pp. [cited by applicant]
Virani et al., “Heart Disease and Stroke Statistics—2020 Update”, American Heart Association Circulation, Mar. 3, 2020, 458 pp. [cited by applicant]
Yang et al., “Identification of myocardial infarction (MI) using spatio-temporal heart dynamics”, Medical Engineering & Physics, Aug. 17, 2011, 13 pp. [cited by applicant]
Zhang et al. “Atlas-Based Quantification of Cardiac Remodeling Due to Myocardial Infarction”, PLOS ONE, vol. 9, Issue 10, Oct. 2014, 13 pp. [cited by applicant]
Zhang et al., “An up-to-date comparison of state-of-the-art classification algorithms”, Expert Systems With Applications, vol. 82, Apr. 2017, pp. 128-150. [cited by applicant]