IP Library › Granted Patent US 12,691,227
Granted Patent B2
US 12,691,227 · App. 17/457,526 · Granted Jul 28, 2026

Devices and methods for precision dose delivery

Inventors: Trevor Langley (Rensselaer, NY); Justin Bechstein (Philadelphia, PA); Jeremy Odegard (Hudson, WI); Sibgat Ulla (Rensselaer, NY); Daniel Halbig (Rensselaer, NY); Bryan Grygus (Clifton Park, NY); Prithvi Singh (Rensselaer, NY); Andrew Dumont (Rensselaer, NY); David Nett (Rensselaer, NY); Tasha Gillum (Rensselaer, NY); Ryan Ainsworth (Rensselaer, NY)
Assignee: Regeneron Pharmaceuticals, Inc.
A61M5/31505A61M5/3135A61M5/3146A61M5/31536A61M5/31583A61F9/0008A61M2005/3139A61M2005/31508A61M2005/3154A61M2205/584
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Quick Facts
Patent No.
US 12,691,227
App. No.
17/457,526
Filed
Dec 3, 2021
Granted
Jul 28, 2026
Kind
B2
Art Unit
3783
USPC
604/227
Abstract

Disclosed herein are devices and methods for delivering a predetermined volume of a drug substance or other product including a fluid. An exemplary device may include a body configured to receive a drug substance therein, and a plunger rod disposed at least partially inside the body to distally move a stopper in the body. The device may include a component configured to regulate distal movement of the plunger rod in a priming step and in a subsequent delivery step, so that the device may be accurately primed and may accurately dispense a predetermined volume of a drug substance.

Claims (36)

1 . A drug delivery device, comprising:

a body;

a plunger rod having a distal end contacting a stopper inside the body, and a proximal end including an actuation portion with a thumb pad;

a plurality of protrusions extending from the actuation portion; and

a blocking component disposed on the body, the blocking component including a proximal collar having a plurality of slots,

wherein, when the protrusions and the slots are in a first configuration relative to one another, the blocking component restricts distal movement of the plunger rod to a first stopping point, and when the protrusions and the slots are in a second configuration, the blocking component restricts distal movement of the plunger rod to a second stopping point,

wherein, in the second configuration, the slots are configured to receive the protrusions upon distal movement of the plunger rod.

2 . The drug delivery device of claim 1 , wherein the protrusions and the slots are movable from the first configuration to the second configuration by rotation of the actuation portion about a longitudinal axis in relation to the blocking component, and wherein when the protrusions and the slots are in the second configuration, the protrusions and the slots are not movable to the first configuration.

3 . The drug delivery device of claim 1 , wherein a difference between the first stopping point and the second stopping point is equivalent to a distance that the stopper must travel to expel a predetermined volume of a drug product from a distal end of the body, and wherein the plunger rod is prevented from moving from the second stopping point to the first stopping point.

4 . The drug delivery device of claim 1 , wherein the drug delivery device is changeable:

(a) from a pre-use state to a primed state, by longitudinally moving the plunger rod until the plunger rod reaches the first stopping point;

(b) from the primed state to a delivery state by rotating the plunger rod in relation to the blocking component until the protrusions and the blocking component are in the second configuration; and

(c) from a delivery state to a used state by longitudinally moving the plunger rod until the plunger reaches the second stopping point, and

wherein the drug delivery device is not changeable from the used state to the delivery state, from the delivery state to the primed state, or from the primed state to the pre-use state.

5 . The drug delivery device of claim 1 , wherein the plunger rod includes a longitudinal length that is greater than a longitudinal length of the body.

6 . The drug delivery device of claim 1 , wherein at least a portion of the body is transparent.

7 . The drug delivery device of claim 1 , wherein the body contains an ophthalmic drug product.

8 . The drug delivery device of claim 1 , wherein the drug delivery device is prefilled with an antagonist of VEGF and/or ANG-2.

9 . The drug delivery device of claim 1 , wherein the drug delivery device is prefilled with aflibercept, alirocumab, abicipar pegol, bevacizumab, brolucizumab, conbercept, dupilumab, evolocumab, tocilizumab, certolizumab, abatacept, rituximab, infliximab, ranibizumab, sarilumab, adalimumab, anakinra, trastuzumab, pegfilgrastim, interferon beta-1a, insulin glargine, epoetin alpha, darbepoetin, filigrastim, golimumab, etanercept, antigen-binding fragments thereof, or combinations thereof.

10 . The drug delivery device of claim 1 , wherein the drug delivery device is prefilled with aflibercept.

11 . The drug delivery device of claim 1 , wherein the body is made of glass.

12 . The drug delivery device of claim 1 , wherein the drug delivery device is silicone-free.

13 . A drug delivery device, comprising:

a body;

a plunger rod including a proximal neck and a distal neck, wherein the proximal neck and the distal neck are rotationally offset from one another;

a flange including an opening, wherein the flange is coupled to the body, and configured to allow the plunger rod to extend into the body through the opening when the plunger rod is oriented in at least one of two configurations relative to the flange;

wherein, when the plunger rod is in a first configuration relative to the flange, the distal neck is misaligned with the opening and the flange restricts distal movement of the plunger rod through the opening, and when the plunger rod is in a second configuration relative to the flange, the distal neck is aligned with the opening and the flange allows distal movement of the plunger rod through the opening until the proximal neck abuts the flange.

14 . The drug delivery device of claim 13 , wherein, when the plunger rod is in the first configuration relative to the flange, the proximal neck is aligned with the opening and the flange restricts distal movement of the plunger rod through the opening until the distal neck is received through the opening.

15 . The drug delivery device of claim 13 , wherein when the plunger rod is in the second configuration relative to the flange, the proximal neck is misaligned with the opening and the flange restricts distal movement of the plunger rod through the opening until the plunger rod is returned to the first configuration.

16 . The drug delivery device of claim 13 , wherein the distal neck includes a tapered distal side that is configured to orient the plunger rod toward the second configuration.

17 . The drug delivery device of claim 13 , wherein the plunger rod includes a proximal stop positioned proximal to the proximal neck and the distal neck;

wherein the proximal neck and the distal neck have a similar shape, and the proximal stop is sized greater than the proximal neck and the distal neck.

18 . The drug delivery device of claim 13 , wherein the opening includes a geometry that is configured to inhibit the distal neck from extending out of the body upon being received through the flange and into the body.

19 . The drug delivery device of claim 13 , wherein the opening includes a geometry that is configured to inhibit the proximal neck from extending out of the body upon being received through the flange and into the body.

20 . The drug delivery device of claim 13 , wherein the flange includes an open channel positioned along a sidewall of the flange, and the body includes a lateral rim along a proximal end of the body.

21 . The drug delivery device of claim 20 , wherein the open channel is configured to slidably receive the lateral rim to couple the flange to the body.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 2, 2025
From: ULLA, SIBGAT; LANGLEY, TREVOR; HALBIG, DANIEL; BECHSTEIN, JUSTIN; NETT, DAVID; ODEGARD, JEREMY; GILLUM, TASHA; AINSWORTH, RYAN; GRYGUS, BRYAN; DUMONT, ANDREW; SINGH, PRITHVI
To: REGENERON PHARMACEUTICALS, INC.
Reel/Frame 069719/0775 →
Continuity (4)
Continuation PCTUS2020036200 · Jun 4, 2020
Provisional Application 62860481 · Jun 12, 2019
Provisional Application 62857678 · Jun 5, 2019
Related Publication 20220160968A1 · May 26, 2022
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