IP Library › Patent Application 17465354
Patent Application
App. No. 17/465,354

FIXED DOSE COMBINATIONS AND FORMULATIONS COMPRISING ETC1002 AND ONE OR MORE STATINS AND METHODS OF TREATING OR REDUCING THE RISK OF CARDIOVASCULAR DISEASE

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Patent No.
US None
App. No.
17/465,354
Abstract

Disclosed herein are compositions comprising fixed doses of ETC-1002 and one or more statins. Also disclosed herein are methods for using fixed doses of ETC-1002 and one or more statins. Uses include methods of treating cardiovascular disease or reducing the risk of cardiovascular disease in a subject. Uses also include methods of treating hypercholesterolemia in a subject.

Claims (25)

1 . A fixed-dose combination of ETC-1002 and one or more statins selected from the group consisting of rosuvastatin, simvastatin, pravastatin, lovastatin, fluvastatin, pitavastatin, and atorvastatin, wherein

the fixed dose of ETC-1002 is 120 mg or 180 mg,

the fixed dose of rosuvastatin is 20-40 mg,

the fixed dose of simvastatin is 40-80 mg,

the fixed dose of pravastatin is 80 mg,

the fixed dose of lovastatin is 20-40 mg,

the fixed dose of fluvastatin is 20-80 mg,

the fixed dose of pitavastatin is 1-4 mg, and

the fixed dose of atorvastatin is 40-80 mg.

2 . The fixed-dose combination of claim 1 , wherein the fixed dose of ETC-1002 is 120 mg.

3 . The fixed-dose combination of claim 1 , wherein the fixed dose of ETC-1002 is 180 mg.

4 . The fixed-dose combination of claim 2 , wherein the fixed dose of rosuvastatin is 20-40 mg.

5 . The fixed-dose combination of claim 3 , wherein the fixed dose of rosuvastatin is 20-40 mg.

6 . The fixed-dose combination of claim 2 , wherein the fixed dose of simvastatin is 40-80 mg.

7 . The fixed-dose combination of claim 3 , wherein the fixed dose of simvastatin is 40-80 mg.

8 . The fixed-dose combination of claim 2 , wherein the fixed dose of pravastatin is 80 mg.

9 . The fixed-dose combination of claim 3 , wherein the fixed dose of pravastatin is 80 mg.

10 . The fixed-dose combination of claim 2 , wherein the fixed dose of lovastatin is 20-40 mg.

11 . The fixed-dose combination of claim 3 , wherein the fixed dose of lovastatin is 20-40 mg.

12 . The fixed-dose combination of claim 2 , wherein the fixed dose of fluvastatin is 20-80 mg.

13 . The fixed-dose combination of claim 3 , wherein the fixed dose of fluvastatin is 20-80 mg.

14 . The fixed-dose combination of claim 2 , wherein the fixed dose of pitavastatin is 1-4 mg.

15 . The fixed-dose combination of claim 3 , wherein the fixed dose of pitavastatin is 1-4 mg.

16 . The fixed-dose combination of claim 2 , wherein the fixed dose of atorvastatin is 40-80 mg.

17 . The fixed-dose combination of claim 3 , wherein the fixed dose of atorvastatin is 40-80 mg.