Botanical modulator of metabolic disorders
Plant-based inhibitors of MMP-9 that also function as PPAR-γ agonists, and the use of such plant-based inhibitors/agonists in modulating metabolic disorders is disclosed. The plant-based inhibitor/agonist is at least an extract obtained from the leaf of the genus Vaccinium.
1. A composition comprising:
a botanical extract of a leaf of Vaccinium macrocarpon,
wherein the botanical extract is present in an amount of about 15.0 μg/mL to about 750.0 μg/mL,
wherein the botanical extract comprises at least isoquercetin and kaempferol and is free of anthocyanins,
wherein the extract is obtained by extracting dried ground cranberry leaf powder with a solvent of ethanol in water and evaporating the solvent, and
a carrier,
wherein the composition exhibits modulation of one or more metabolic disorders.
2. The composition according to claim 1 , wherein the composition exhibits MMP-9 inhibition.
3. The composition according to claim 1 , wherein the composition exhibits PPAR-γ agonist activity.
4. The composition according to claim 1 , wherein the composition is a dietary supplement.
5. The dietary supplement according to claim 4 , wherein the dietary supplement is in solid dosage form.