IP Library › Patent Application 17488137
Patent Application
App. No. 17/488,137

PTH Prodrugs

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Quick Facts
Patent No.
US None
App. No.
17/488,137
Abstract

The present invention relates to PTH prodrugs, pharmaceutical compositions comprising such PTH prodrugs and their uses.

Claims (14)

1 - 18 . (canceled)

19 . A parathyroid hormone (PTH) conjugate of formula (IIf-i) or a pharmaceutically acceptable salt thereof:

wherein

the unmarked dashed line indicates the attachment to the N-terminal nitrogen of a PTH moiety having the sequence of SEQ ID NO:51; and

the dashed line marked with the asterisk indicates attachment to a moiety

wherein

m and p are independently an integer ranging from and including 400 to 500.

20 . The PTH conjugate or a pharmacological salt thereof of claim 19 , wherein the moiety

has a molecular weight of about 40 kDa.

21 . The PTH conjugate or a pharmacological salt thereof of claim 19 , wherein m and p are the same integer.

22 . The PTH conjugate or a pharmacological salt thereof of claim 19 , wherein m and p are about 450.

23 . A pharmaceutical composition comprising at least one PTH conjugate or a pharmaceutically acceptable salt thereof of claim 19 and at least one excipient.

24 . The pharmaceutical composition of claim 19 , wherein the pharmaceutical composition has a pH ranging from and including pH 4 to pH 6.

25 . A method of treating a patient having hypoparathyroidism comprising administering an effective amount of the PTH conjugate or pharmaceutically acceptable salt thereof of claim 1 or a pharmaceutical composition comprising such PTH conjugate or pharmaceutically acceptable salt thereof to the patient.