Synergistic composition for osteoarthritis

1. A method for treating at least one disease condition selected from the group consisting of inflammation, arthritis, joint pain, rheumatoid arthritis, osteoarthritis, chronic non-rheumatoid arthritis, and collagen degradation in a patient in need thereof, comprising administering to the patient an effective amount of a composition comprising:

a combination of therapeutically effective amounts of:

a) an alcohol or hydroalcohol extract of a Tamarindus indica seed, wherein the alcohol or hydroalcohol extract comprises proanthocyanidins; and

b) at least one of:

a water extract of the Tamarindus indica seed, the water extract comprising polysaccharides, wherein the alcohol or hydroalcohol extract of the Tamarindus indica seed and the water extract are used in a ratio ranging from 1:1 to 10:1; and

a Curcuma longa rhizome extract comprising curcuminoids, wherein the alcohol or hydroalcohol extract of the Tamarindus indica seed and the Curcuma longa rhizome extract are used in a ratio ranging from 1:4 to 4:1.

2. The method according to claim 1 , wherein the combination comprises:

a) the alcohol or hydroalcohol extract of the Tamarindus indica seed, wherein the alcohol or hydroalcohol extract comprises proanthocyanidins; and

b) the Curcuma longa rhizome extract comprising curcuminoids.

3. The method according to claim 2 , wherein the alcohol used for preparing the alcohol or hydroalcohol extract of the Tamarindus indica seed is selected from the group consisting of methanol, ethanol, propanol, isopropanol, butanol, tert-butanol, and mixtures thereof.

4. The method according to claim 2 , wherein the Curcuma longa rhizome extract is prepared from a Curcuma longa rhizome using a solvent selected from the group consisting of methanol, ethanol, propanol, isopropanol, n-butanol, tert-butanol, acetone, ethyl acetate, and mixtures thereof.

5. The method of claim 2 , wherein the combination further comprises the water extract of the Tamarindus indica seed, the water extract comprising polysaccharides.

6. The method according to claim 2 , wherein the combination is present in an amount which is effective for the treatment of inflammation.

7. The method according to claim 2 , wherein the composition further comprises a pharmaceutically, nutraceutically, or dietetically acceptable carrier or excipient.

8. The method according to claim 7 , wherein the pharmaceutically, nutraceutically, or dietetically acceptable carrier or excipient is selected from the group consisting of surfactants, binders, diluents, disintegrants, lubricants, preservatives, stabilizers, buffers, polymers, colors, flavors, suspensions and drug delivery systems.

9. The method according to claim 2 , wherein the combination comprises from greater than 0% to 30% of the carrier or excipient.

10. The method according to claim 2 , wherein the combination comprises:

from 40% to 70% of the alcohol or hydroalcohol extract of the Tamarindus indica seed; and

from greater than 0% to 15% of the excipient or carrier.

11. The method according to claim 2 , wherein the combination comprises:

60% of the alcohol or hydroalcohol extract of the Tamarindus indica seed;

30% of the Curcuma longa rhizome extract comprising curcuminoids; and

10% of the excipient or carrier.

12. The method according to claim 2 , wherein the composition is formulated to be administered orally or topically.

13. The method according to claim 1 , wherein the combination comprises

a) the alcohol or hydroalcohol extract of the Tamarindus indica seed, wherein the alcohol or hydroalcohol extract comprises proanthocyanidins; and

b) the water extract of the Tamarindus indica seed, the water extract comprising polysaccharides.

14. The method according to claim 13 , wherein the composition further comprises a pharmaceutically, nutraceutically, or dietetically acceptable carrier or excipient.

15. The method according to claim 14 , wherein the pharmaceutically, nutraceutically, or dietetically acceptable carrier or excipient is selected from the group consisting of surfactants, binders, diluents, disintegrants, lubricants, preservatives, stabilizers, buffers, polymers, colors, flavors, suspensions and drug delivery systems.

16. The method according to claim 13 , wherein the combination is present in an amount which is effective for the treatment of inflammation.

17. The method according to claim 13 , wherein the composition is formulated to be administered orally or topically.

18. The method according to claim 13 , wherein the alcohol used for preparing the alcohol or hydroalcohol extract of the Tamarindus indica seed is selected from the group consisting of methanol, ethanol, propanol, isopropanol, butanol, tert-butanol, and mixtures thereof.

19. The method according to claim 13 , wherein the composition further comprises a Curcuma longa rhizome extract comprising curcuminoids.

20. The method according to claim 18 , wherein the Curcuma longa rhizome extract is prepared from a Curcuma longa rhizome using a solvent selected from the group consisting of methanol, ethanol, propanol, isopropanol, n-butanol, tert-butanol, acetone, ethyl acetate, and mixtures thereof.

21. A method for treating at least one disease condition selected from the group consisting of inflammation, arthritis, joint pain, rheumatoid arthritis, osteoarthritis, chronic non-rheumatoid arthritis, and collagen degradation in a patient in need thereof, comprising administering to the patient an effective amount of a composition comprising:

a) a Tamarindus indica seed extract, comprising:

an alcohol or hydroalcohol extract of a Tamarindus indica seed, wherein the alcohol or hydroalcohol extract comprises proanthocyanidins; and

a water extract of a Tamarindus indica seed, the water extract comprising polysaccharides,

wherein the alcohol or hydroalcohol extract and the water extract are used in a ratio ranging from 1:1 to 10:1; and

b) a Curcuma longa rhizome extract comprising curcuminoids.