Free-polyunsaturated-fatty-acid-containing composition and method for manufacturing same
Provided is a free-polyunsaturated-fatty-acid-containing composition that has a total metal content of 0.1 ppm or less and that comprises at least one free polyunsaturated fatty acid having 20 or more carbon atoms, in an amount that is at least 80.0% of the amount of fatty acids in the composition; and a method for manufacturing a free-polyunsaturated-fatty-acid-containing composition, comprising: providing a raw material composition containing at least one polyunsaturated fatty acid having 20 or more carbon atoms; performing a hydrolysis treatment on a reaction solution prepared by combining the provided raw material composition, a lower alcohol, water having a total metal content of 0.01 ppm or less, and an alkali catalyst; and limiting the contact between the reaction composition and the metal after the hydrolysis treatment so that the product T [cm 2 ×days] of the contact surface area [cm 2 ] per 1 g and the contact time [days] between the composition and the metal is 100 or less.
1. A method of manufacturing a free polyunsaturated fatty acid-containing composition, the method comprising:
providing a raw material composition containing at least one polyunsaturated fatty acid having 20 or more carbons;
performing hydrolysis treatment on a reaction solution prepared by combining the provided raw material composition, a lower alcohol, water having an iron content of 0.01 ppm or less, and an alkali catalyst; and
after hydrolysis treatment, limiting contact between the reaction solution and any metal surface such that a product T (cm 2 ·day), calculated by multiplying (i) the contact surface area (cm 2 ) per 1 g of the reaction solution with the metal surface and (ii) a corresponding contact time (day) becomes 100 or less, does not exceed 100 cm 2 ·day, thereby obtaining the free polyunsaturated fatty acid-containing composition.
2. The method according to claim 1 , wherein the product T does not exceed 80 cm 2 ·day.
3. The method according to claim 1 , wherein a content of the free polyunsaturated fatty acid having 20 or more carbons in the raw material composition is 80.0% or greater more of the fatty acids in the composition.
4. The method according to claim 1 , wherein the hydrolysis treatment is performed at a temperature of 10° C. or lower.
5. The method according to claim 1 , wherein the iron content of the water used in the hydrolysis treatment is 0.005 ppm or less.
6. The method according to claim 1 , wherein the polyunsaturated fatty acid in the raw material composition is in the form of a polyunsaturated fatty acid alkyl ester.
7. The method according to claim 1 , wherein the raw material composition is derived from a microbial raw material.
8. The method according to claim 1 , wherein the reaction composition contacts with a surface of iron, a surface of stainless steel, a surface of steel, a surface of tin plate, or a surface of steel that is coated with zinc phosphate after hydrolysis treatment.
9. The method according to claim 8 , wherein the reaction composition contacts with a surface of stainless steel after hydrolysis treatment.
10. The method according to claim 1 , wherein the lower alcohol has one carbon atom, two carbon atoms, or three carbon atoms.
11. The method according to claim 10 , wherein the lower alcohol is ethanol.
12. The method according to claim 1 , wherein the polyunsaturated fatty acid is selected from the group consisting of eicosadienoic acid, dihomo-γ-linolenic acid, Mead acid, eicosatetraenoic acid, arachidonic acid, eicosapentaenoic acid, docosatetraenoic acid, docosapentaenoic acid, and docosahexaenoic acid.
13. The method according to claim 12 , wherein the polyunsaturated fatty acid is dihomo-γ-linolenic acid.