Therapeutic nanomaterials
Disclosed herein is a delivery vehicle based on DNA-inspired Janus based nanotubes (JBNTs) for anti-viral treatment. The nanoparticles (NPs) are based the JBNTs conjugated with targeting moieties such as small molecules, aptamers, and peptides.
1. A composition comprising a compound of Formula (I):
or a pharmaceutically acceptable salt thereof, wherein:
R 1 is H or CH 3 ;
R 2 is (CH 2 ) j , (CH 2 CH 2 O) k or (CH 2 CH 2 NH) m ;
j, k, and m are the chemical subscripts for the moieties listed in R2 and each it independently represents 0-200 of the repeating moieties;
L is absent; and
X is folic acid
wherein the composition has a pH of about 1 to about 10.
2. The composition of claim 1 , wherein the therapeutic agent is targeting molecule that is a surface targeting modifier, a membrane dipeptidase targeting molecule, an endoplasmic reticulum (ER) targeting molecule, a mitochondrial membrane targeting molecule, a nucleus targeting molecule.