Efficient tobramycin compound conjugate compositions
Disclosed herein are compositions comprising tobramycin or a tobramycin derivative that exhibit improvements in permeation of corneal cells, retention in corneal cells, or both. Such compositions can comprise tobramycin or tobramycin derivative(s) complexed to an agent which facilitates improved permeation of corneal cells, retention in corneal cells, or both. The invention also relates to a process of preparing such compositions.
1. A pharmaceutically acceptable composition for treating an infection caused by a bacteria in a mammalian eye comprising an effective amount of an ophthalmologically suitable complex, the complex comprising:
(a) tobramycin at 0.3-3% w/v and
(b) polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft co-polymer (PCL-PVAc-PEG) at 0.3-3% w/v, wherein the PCL-PVAc-PEG forms a stable complex with tobramycin and the PCL-PVAc-PEG detectably promotes the uptake of tobramycin by corneal cells, the retention of tobramycin by corneal cells, or both, as compared to the free (noncomplexed) tobramycin.
2. The pharmaceutically acceptable composition of claim 1 , wherein the composition comprises tobramycin in an amount of about 1% w/v to about 3% w/v.
3. The pharmaceutically acceptable composition of claim 1 , wherein the composition comprises PCL-PVAc-PEG in an amount of about 1% w/v to about 3% w/v.
4. The pharmaceutically acceptable composition of claim 1 , wherein the composition is effective in treating the infection caused by the bacteria when administered no more than two times per day.
5. The pharmaceutically acceptable composition of claim 4 , wherein the composition is effective in treating the infection caused by the bacteria when administered no more than once per day.
6. The pharmaceutically acceptable composition of claim 4 , wherein the composition is provided as a solution, and a single administration comprises no more than two drops of the composition to the infected eye.
7. The pharmaceutically acceptable composition of claim 6 , wherein the composition is provided as a solution, and a single administration comprises no more than one drop of the composition to the infected eye.
8. The pharmaceutically acceptable composition of claim 5 , wherein the composition is provided as a solution, and a single administration comprises no more than two drops of the composition to the infected eye.
9. The pharmaceutically acceptable composition of claim 8 , wherein the composition is provided as a solution, and a single administration comprises no more than one drop of the composition to the infected eye.