IP Library › Granted Patent US 11,466,000

Granted Patent B2

US 11,466,000 · App. 17/521,711 · Granted Oct 11, 2022

Heteroaryl derivative, method for producing same, and pharmaceutical composition comprising same as effective component

Inventors: Youn Ho Lee (Incheon, KR); Ju Hee Kang (Incheon, KR); Se In Kang (Incheon, KR); Yi Kyung Ko (Incheon, KR); Eun Hwa Ko (Incheon, KR); Hwan Geun Choi (Seoul, KR); Jung Beom Son (Incheon, KR); Nam Doo Kim (Incheon, KR)

Assignee: VORONOI INC.

C07D413/14 A61P35/00 C07D413/04 C07D487/08 C07D498/08

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Quick Facts

Patent No.: US 11,466,000
App. No.: 17/521,711
Granted: Oct 11, 2022
Kind: B2

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Abstract

The present invention relates to a 6-(isooxazolidin-2-yl)-N-phenylpyrimidin-4-amine derivative, and a pharmaceutical composition for preventing or treating cancer comprising the compound as an effective component. The compound exhibits high inhibitory activity against an epidermal growth factor receptor (EGFR) variant, or wild-type or variants of one or more of ERBB2 and ERBB4, and thus may be usefully used in the treatment of cancers in which same are expressed. In particular, the compound exhibits excellent inhibitory activity on proliferation of lung cancer cell lines, and thus can be usefully used in the treatment of lung cancer.

Claims (1165)

1. A compound of Formula 1,

wherein:

R 1 is hydrogen, halogen, C 1-8 alkyl, or C 1-8 alkoxy, where the C 1-8 alkyl and C 1-8 alkoxy of R 1 are, respectively and independently, substituted or unsubstituted by at least one halogen;

R 2 is hydrogen or —NR 7 R 8 , where R 7 and R 8 are, respectively and independently, hydrogen or C 1-8 alkyl, or the R 7 and R 8 are linked together with the N atom to which they are bonded to form a heterocycloalkyl of 3 to 12 atoms, where the C 1-8 alkyl or 3 to 12 atom heterocycloalkyl of R 7 and R 8 are, respectively and independently, substituted or unsubstituted by at least one substituent selected from the group consisting of C 1-8 alkyl, C 1-8 alkoxy and C 1-8 alkylamino;

where the substituents R are, respectively and independently, additionally substituted or unsubstituted by at least one substituent selected from the group consisting of halogen; carbonyl; C 1-8 alkyl substituted or unsubstituted by hydroxy or C 1-8 alkylamino; C 2-8 alkenyl; C 1-8 alkoxy; C 1-8 alkylamino; C 1-8 alkylcarbonyl; and a 3 to 12 atom heterocycloalkyl substituted or unsubstituted by C 1-8 alkyl, and where the R 12 and R 13 are, respectively and independently, by hydrogen, C 1-8 alkyl, C 2-8 alkenyl, C 1-8 alkylcarbonyl, C 2-8 alkenylcarbonyl, or a 3 to 12 atom heterocycloalkyl substituted or unsubstituted by C 1-8 alkyl;

R 4 is —NHC(═O)R 14 C═CR 15 R 16 , where the R 14 , R 15 and R 16 are, respectively and independently, hydrogen, halogen, or C 1-8 alkyl substituted or unsubstituted by C 1-8 alkylamino;

R 5 is C 1-8 alkyl, an aryl of 3 to 12 atoms, a heteroaryl of 3 to 12 atoms, or a heterocycloalkyl of 3 to 12 atoms, and the C 1-8 alkyl, aryl of 3 to 12 atoms, heteroaryl of 3 to 12 atoms, or heterocycloalkyl of 3 to 12 atoms of R 5 are, respectively and independently, substituted or unsubstituted by at least one substituent J selected from the group consisting of halogen, cyano, C 1-8 alkyl substituted or unsubstituted by halogen, aryl of 3 to 12 atoms, heteroaryl of 3 to 12 atoms, heterocycloalkyl of 3 to 12 atoms, C 2-8 alkenyl, C 1-8 alkoxy, C 2-8 alkynyl and C 1-8 alkylamino, wherein each of the substituents J are independently substituted or unsubstituted with one or more substituents selected from the group consisting of halogen, C 1-8 alkyl substituted or unsubstituted by halogen, C 1-8 alkoxy, and C 1-8 alkylamino,

and R 6 is hydrogen or C 1-8 alkyl,

or a stereoisomer, hydrate, or pharmaceutically acceptable salt thereof.

2. The compound of claim 1 , wherein:

R 1 is hydrogen, halogen, C 1-8 alkyl, or C 1-8 alkoxy substituted or unsubstituted by at least one halogen,

R 2 is hydrogen or —NR 7 R 8 , where R 7 and R 8 are, respectively and independently, hydrogen or C 1-8 alkyl, or the R 7 and R 8 are linked together with the N atom to which they are bonded to form a heterocycloalkyl of 3 to 12 atoms, and the C 1-8 alkyl of R 7 and R 8 are, respectively and independently, substituted or unsubstituted by at least one substituent selected from the group consisting of C 1-8 alkoxy and C 1-8 alkylamino, and the 3 to 12 atom heterocycloalkyl formed by the bonding of R 7 and R 8 is substituted or unsubstituted by at least one substituent selected from the group consisting of C 1-8 alkyl and C 1-8 alkoxy,

R 3 is hydrogen, —NR 9 R 10 or —OR 11 , where R 9 , R 10 and R 11 are, respectively and independently, hydrogen or C 1-8 alkyl, or the R 9 and R 10 are linked together with the N atom to which they are bonded to form a heterocycloalkyl of 3 to 12 atoms or heteroaryl of 3 to 12 atoms, and the C 1-8 alkyls of R 9 , R 10 and R 11 are, respectively and independently, substituted or unsubstituted by at least one substituent R selected from the group consisting of C 1-8 alkoxy and C 1-8 alkylamino, where the 3 to 12 atom heterocycloalkyl formed by the bonding of R 9 and R 10 is substituted or unsubstituted by at least one substituent R a selected from the group consisting of hydroxy, C 1-8 alkyl, C 1-8 alkoxy, C 1-8 alkylamino, C 1-8 alkylcarbonyl, —NR 12 R 13 , and heterocycloalkyls of 3 to 12 atoms, and the C 1-8 alkyl, C 1-8 alkoxy, C 1-8 alkylamino, and C 1-8 alkylcarbonyl of the substituent R a are, respectively and independently, additionally substituted or unsubstituted by at least one substituent selected from the group consisting of C 1-8 alkyl, C 1-8 alkoxy, C 1-8 alkylamino, and heterocycloalkyls of 3 to 12 atoms, wherein the heterocycloalkyl of 3 to 12 atoms of the substituent R a is additionally substituted or unsubstituted by at least one substituent selected from the group consisting of halogen; carbonyl; C 1-8 alkyl substituted or unsubstituted by a hydroxy or a C 1-8 alkylamino; C 2-8 alkenyl; C 1-8 alkoxy; C 1-8 alkylamino; C 1-8 alkylcarbonyl; and, a 3 to 12 atom heterocycloalkyl substituted or unsubstituted by C 1-8 alkyl, where the R 12 and R 13 are, respectively and independently, hydrogen, C 1-8 alkylcarbonyl, C 2-8 alkenylcarbonyl, or a 3 to 12 atom heterocycloalkyl substituted or unsubstituted by C 1-8 alkyl, and the 3 to 12 atom heteroaryl formed by the bonding of R 9 and R 10 is substituted or unsubstituted by C 1-8 alkyl,

R 4 is —NHC(═O)R 14 C═CR 15 R 16 , where the R 14 is hydrogen or halogen, and the R 15 and R 16 are, respectively and independently, hydrogen or C 1-8 alkyl substituted or unsubstituted by an alkylamino of C 1-8 ,

R 5 is a C 1-8 alkyl substituted by a 3 to 12 atom aryl or a 3 to 12 atom heteroaryl; an aryl of 3 to 12 atoms; or a heteroaryl of 3 to 12 atoms, where the aryl of 3 to 12 atoms and the heteroaryl of 3 to 12 atoms of R 5 are, respectively and independently, substituted or unsubstituted by at least one substituent selected from the group consisting of halogen, cyano, C 1-8 alkyl, C 1-8 alkoxy, and C 2-8 alkynyl, C 1-8 alkyl substituted with a 3 to 12 atom aryl or 3 to 12 atom heteroaryl of R 5 is substituted or unsubstituted by at least one substituent selected from the group consisting of halogen, C 1-8 alkyl substituted or unsubstituted by halogen, C 1-8 alkoxy and C 1-8 alkylamino,

and R 6 is hydrogen or C 1-8 alkyl, or a stereoisomer, hydrate, or pharmaceutically acceptable salt thereof.

3. The compound of claim 1 , wherein:

R 1 is hydrogen, halogen, C 1-4 alkyl, or C 1-4 alkoxy substituted or unsubstituted by at least one halogen,

R 2 is hydrogen or —NR 7 R 8 , where R 7 and R 8 are linked, together with the N atom to which they are bonded, to form a 3 to 8 atom heterocycloalkyl, where the 3 to 8 atom heterocycloalkyl formed by the bonding of R 7 and R 8 is substituted or unsubstituted by at least one C 1-4 alkyl,

R 3 is hydrogen, —NR 9 R 10 or —OR 11 , where R 9 , R 10 , and R 11 are, respectively and independently, C 1-6 alkyl, or R 9 and R 10 are linked together with the N atom with which they are bonded to form a 3 to 10 atom heterocycloalkyl or 3 to 8 atom heteroaryl, wherein the C 1-6 alkyls of R 9 , R 10 , and R 11 are, respectively and independently, substituted or unsubstituted by at least one substituent selected from the group consisting of C 1-4 alkylamino and C 1-4 alkoxy, and the 3 to 10 atom heterocycloalkyl formed by the bonding of R 9 and R 10 is substituted or unsubstituted by at least one substituent R b selected from the group consisting of hydroxy, C 1-6 alkyl, C 1-4 alkoxy, C 1-4 alkylamino, C 1-4 alkylcarbonyl, —NR 12 R 13 and heterocycloalkyls of 3 to 10 atoms, the C 1-6 alkyl, C 1-4 alkoxy, and C 1-4 alkylamino of the substituent R b are, respectively and independently, additionally substituted or unsubstituted by at least one substituent selected from the group consisting of C 1-6 alkyl, C 1-4 alkoxy, and C 1-4 alkylamino, the 3 to 10 atom heterocycloalkyl of substituent R b is additionally substituted or unsubstituted by at least one substituent selected from the group consisting of halogen; carbonyl; C 1-6 alkyl substituted or unsubstituted by C 1-4 alkylamino; C 2-4 alkenyl; C 1-4 alkylamino; C 1-4 alkylcarbonyl; and, a 3 to 8 atom heterocycloalkyl substituted or unsubstituted by C 1-4 alkyl, wherein the R 12 and R 13 are, respectively and independently, hydrogen, C 2-4 alkenylcarbonyl, or 3 to 8 atom heterocycloalkyl substituted or unsubstituted by C 1-4 alkyl, and the 3 to 8 atom heterocycloalkyl formed by the bonding of R 9 and R 10 is substituted or unsubstituted by C 1-4 alkyl,

R 4 is —NHC(═O)R 14 C═CR 15 R 16 , wherein R 14 is hydrogen or halogen, and R 15 and R 16 are, respectively and independently, hydrogen or C 1-4 alkyl substituted by an alkylamino of C 1-4 ,

R 5 is a C 1-4 alkyl; a 3 to 8 atom aryl; or a 3 to 8 atom heteroaryl substituted by a 3 to 8 atom aryl or 3 to 8 atom heteroaryl; wherein the 3 to 8 atom aryl or 3 to 8 atom heteroaryl of R 5 are, respectively and independently, substituted or unsubstituted by at least one substituent selected from the group consisting of halogen, cyano, C 1-4 alkyl substituted or unsubstituted by halogen, C 1-4 alkoxy, and C 2-4 alkynyl, wherein the C 1-4 alkyl substituted by a 3 to 8 atom aryl or 3 to 8 atom heteroaryl of R 5 is substituted or unsubstituted by at least one substituent selected from the group consisting of halogen, C 1-4 alkyl substituted or unsubstituted by halogen, and C 1-4 alkylamino;

and R 6 is hydrogen or C 1-4 alkyl, or a stereoisomer, hydrate, or pharmaceutically acceptable salt thereof.

4. The compound of claim 1 , wherein:

R 1 is hydrogen, halogen, C 1-4 alkyl or C 1-4 alkoxy substituted or unsubstituted by at least one halogen;

R 2 is hydrogen or —NR 7 R 8 , where R 7 and R 8 are linked together with the N atom to which they are bonded to form a 3 to 8 atom heterocycloalkyl having one or two N atoms, where the 3 to 8 atom heterocycloalkyl formed by the bonding of R 7 and R 8 is substituted or unsubstituted by at least one C 1-4 alkyl;

R 3 is hydrogen, —NR 9 R 10 , or —OR 11 , where R 9 , R 10 and R 11 are, respectively and independently, C 1-6 alkyl, or R 9 and R 10 are linked together with the N atom to which they are bonded to form a 3 to 10 atom heterocycloalkyl having one or two heteroatoms selected from the group consisting of N and O, or a 3 to 8 atom heteroaryl having one or two heteroatoms selected from the group consisting of N and O, the C 1-6 alkyl of R 9 , R 10 and R 11 are, respectively and independently, substituted or unsubstituted by at least one substituent selected from the group consisting of C 1-4 alkylamino and C 1-4 alkoxy, the 3 to 10 atom heterocycloalkyl formed by the bonding of R 9 and R 10 is substituted or unsubstituted by at least one substituent R c selected from the group consisting of hydroxy, C 1-6 alkyl, C 1-4 alkoxy, C 1-4 alkylamino, C 1-4 carbonyl, —NR 12 R 13 , and 3 to 10 atom heterocycloalkyl having one or two heteroatoms selected from the group consisting of N and O, wherein the C 1-6 alkyl, C 1-4 alkoxy and C 1-4 alkylamino of substituents R c are, respectively and independently, additionally substituted or unsubstituted by at least one substituent selected from the group consisting of C 1-6 alkyl, C 1-4 alkoxy and C 1-4 alkylamino, the 3 to 10 atom heterocycloalkyl of substituents R c is substituted or unsubstituted by halogen; carbonyl; C 1-6 alkyl substituted or unsubstituted by C 1-4 alkylamino; C 2-4 alkenyl; C 1-4 alkylamino; C 1-4 alkylcarbonyl; and C 1-4 alkyl, and additionally substituted or unsubstituted by at least one substituent selected from the group consisting of 3 to 8 atom heterocycloalkyls having one or two heteroatoms selected from the group consisting of N and O, R 12 and R 13 are, respectively and independently, hydrogen, C 2-4 alkenylcarbonyl or C 1-4 alkyl, or are 3 to 8 atom heterocycloalkyls having one or two N atoms, and the 3 to 8 atom heteroaryl formed by the bonding of R 9 and R 10 is substituted or unsubstituted by C 1-4 alkyl;

R 4 is —NHC(═O)R 14 C═CR 15 R 16 , wherein the R 14 is hydrogen or halogen, and the R 15 and R 16 are, respectively and independently, C 1-4 alkyl substituted by hydrogen or C 1-4 alkylamino;

R 5 is a C 1-4 alkyl substituted by a 3 to 8 atom aryl or 3 to 8 atom heteroaryl; 3 to 8 atom aryl; or 3 to 8 atom heteroaryl, the 3 to 8 atom aryl or 3 to 8 atom heteroaryl of R 5 is, respectively and independently, substituted or unsubstituted by at least one substituent selected from the group consisting of halogen, cyano, C 1-4 alkyl substituted or unsubstituted by halogen, C 1-4 alkoxy, and C 2-4 alkynyl, the C 1-4 alkyl substituted by a 3 to 8 atom aryl or a 3 to 8 atom heteroaryl of R 5 is substituted or unsubstituted by at least one substituent selected from the group consisting of halogen, C 1-4 alkyl substituted or unsubstituted by halogen, and C 1-4 alkylamino; and

R 6 is hydrogen or C 1-4 alkyl, or a stereoisomer, hydrate, or pharmaceutically acceptable salt thereof.

5. A compound of Formula 2,

wherein:

R 1 is hydrogen or C 1-4 alkoxy;

R 3 is —X—Y—Z, where X and Y are, respectively and independently, single bonds or 3 to 8 atom heterocycloalkyls comprising at least one N atom, and Z is —NR 17 R 18 or is represented by Chemical Formula 3,

where, in a case where Z is —NR 17 R 18 , at least one of X and Y is the 3 to 8 atom heterocycloalkyl comprising at least one N atom, where R 17 and R 18 are, respectively and independently, a C 1-4 alkyl substituted or unsubstituted by hydrogen or C 1-4 alkylamino, or are linked together with an N atom to which they are bonded to form a 3 to 12 atom heterocycloalkyl;

in a case where Z is Chemical Formula 3, L is a C 1-4 alkylene substituted or unsubstituted by C 1-4 alkyl, M is —NR 19 or —O—, T and Q are, respectively and independently, C 1-4 alkyl substituted or unsubstituted by hydrogen or C 1-4 alkylamino; T and Q are linked to each other to form a 3 to 12 atom heterocycloalkyl substituted or unsubstituted by C 1-4 alkyl; or T and Q are linked to each other, with additional links between at least two different atoms forming a ring, to form a bridged or fused 3 to 12 atom heterocycloalkyl substituted or unsubstituted by a C 1-4 alkyl, R 19 is hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 1-6 alkylcarbonyl, C 1-4 alkylamino, or a 3 to 8 atom heterocycloalkyl;

R 5 is a 3 to 8 atom aralkyl, 3 to 8 atom aryl, or 3 to 8 atom heteroaryl, where the 3 to 8 atom aralkyl, 3 to 8 atom aryl, or 3 to 8 atom heteroaryl of R 5 may be, respectively and independently, substituted or unsubstituted by at least one substituent selected from the group consisting of halogen, cyano, C 1-4 alkyl, and C 1-4 alkoxy, or a stereoisomer, hydrate, or pharmaceutically acceptable salt thereof.

6. The compound of claim 5 , wherein R 1 is hydrogen, methoxy or ethoxy, or a stereoisomer, hydrate, or pharmaceutically acceptable salt thereof.

7. The compound of claim 5 , wherein:

R 3 is —X—Y—Z, where X and Y are, respectively and independently, a single bond, azetidine, pyrrolidine, piperidine or piperazine, and Z is represented by —NR 17 R 18 or Chemical Formula 3,

where, in a case where Z is —NR 17 R 18 , at least one of X and Y is azetidine, pyrrolidine, piperidine or piperazine, where R 17 and R 18 are, respectively and independently methyl or ethyl, or are linked together with an N atom to which they are bonded to be azaspiroctane,

in a case where Z is Chemical Formula 3, L is methylene, ethylene, propylene or butylene substituted or unsubstituted by methyl or ethyl,

M is —NR 19 or —O—, and T and Q are, respectively and independently, methyl or ethyl substituted or unsubstituted by dimethyl amino; M is —NR 19 , and T and Q are linked to each other to form a piperazine substituted or unsubstituted by methyl or ethyl; M is —NR 19 , and T and Q are linked together, with additional links between at least two different atoms among the atoms forming the ring, forming a 6 to 8 atom diazabicycloalkyl substituted or unsubstituted by methyl or ethyl; M is —O—, and T and Q are linked together, forming a morpholine substituted or unsubstituted by methyl or ethyl; or M is —O—, and T and Q are linked together, with additional links between at least two different atoms among the atoms forming the ring, forming a 6 to 8 atom oxazabicycloalkyl substituted or unsubstituted by methyl or ethyl; and

R 19 is methyl, ethyl, propyl, cyclopropyl, cyclopropylmethyl, cyclobutyl, cyclopentyl, prop-2-en-1-yl, acetyl, dimethylamino, or oxetane, or or a stereoisomer, hydrate, or pharmaceutically acceptable salt thereof.

8. The compound of claim 5 , wherein:

R 5 is phenyl, benzyl, pyridine or thiophene, and the phenyl, benzyl, pyridine or thiophene may be, respectively and independently, substituted or unsubstituted by at least one substituent selected from the group consisting of fluoro, chloro, cyano, methyl substituted or unsubstituted by at least one fluoro, and methoxy, or a stereoisomer, hydrate, or pharmaceutically acceptable salt thereof.

9. A compound selected from the group consisting of:

1) N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((6-((S)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

2) N-(4-methoxy-2-morpholino-5-((6-((S)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

3) N-(4-methoxy-2-(4-methylpiperazine-1-yl)-5-((6-((S)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

4) N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

5) N-(4-methoxy-2-morpholino-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

6) N-(4-methoxy-2-(4-methylpiperazine-1-yl)-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

7) N-(2-(4-cyclopropylpiperazine-1-yl)-4-methoxy-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

8) N-(2-(2-(dimethylamino)ethoxy)-4-methoxy-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

9) N-(4-methoxy-2-(4-(4-methylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

10) N-(4-methoxy-2-(4-(1-methylpiperidine-4-yl)piperazine-1-yl)-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

11) N-(4-methoxy-2-(4-morpholinopiperidine-1-yl)-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

12) N-(2-(4-(dimethylamino)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

13) N-(2-((R)-3-(dimethylamino)pyrolidine-1-yl)-4-methoxy-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

14) N-(2-((S)-3-(dimethylamino)pyrolidine-1-yl)-4-methoxy-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

15) N-(2-(4-ethylpiperazine-1-yl)-4-methoxy-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

16) N-(2-(4-acetylpiperazine-1-yl)-4-methoxy-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

17) N-(4-methoxy-2-((2-methoxyethyl)(methyl)amino)-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

18) N-(4-methoxy-2-(4-(oxetane-3-yl)piperazine-1-yl)-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

19) N-(4-methoxy-2-(2-methyl-1H-imidazole-1-yl)-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

20) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide;

21) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-methylpiperazine-1-yl)phenyl)acrylamide;

22) N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((6-((R)-3-(3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

23) N-(5-((6-((R)-3-(3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-methylpiperazine-1-yl)phenyl)acrylamide;

24) N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((6-((R)-3-(3-methoxyphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

25) N-(4-methoxy-5-((6-((R)-3-(3-methoxyphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-methylpiperazine-1-yl)phenyl)acrylamide;

26) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-methylpiperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

27) N-(2-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(3-methoxyphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

28) N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

29) N-(2-(4-methylpiperazine-1-yl)-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

30) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-morpholinopiperidine-1-yl)phenyl)acrylamide;

31) N-(5-((6-((R)-3-(3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-methylpiperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

32) N-(4-methoxy-2-(5-methyl-2,5-diazabicyclo[2.2.1]heptane-2-yl)-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

33) N-(2-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)-4-methoxy-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

34) N-(2-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)-4-methoxy-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

35) N-(4-methoxy-2-(3-methyl-3,6-diazabicyclo[3.1.1]heptane-6-yl)-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

36) N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((6-((R)-3-(6-methylpyridine-3-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

37) N-(5-((6-((R)-3-(4-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide;

38) N-(5-((6-((R)-3-(3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-morpholinopiperidine-1-yl)phenyl)acrylamide;

39) N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((6-((R)-3-(4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

40) N-(4-methoxy-5-((6-((R)-3-(3-methoxyphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-methylpiperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

41) N-(2-(4-(4-ethylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(6-methylpyridine-3-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

42) N-(2-(4-ethylpiperazine-1-yl)-4-methoxy-5-((6-((R)-3-(6-methylpyridine-3-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

43) N-(4-methoxy-5-((6-((R)-3-(6-methylpyridine-3-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-morpholinophenyl)acrylamide;

44) N-(4-methoxy-2-(4-methylpiperazine-1-yl)-5-((6-((R)-3-(6-methylpyridine-3-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

45) N-(4-methoxy-5-((6-((R)-3-(6-methylpyridine-3-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-morpholinopiperidine-1-yl)phenyl)acrylamide;

46) N-(2-(4-cyclopropylpiperazine-1-yl)-4-methoxy-5-((6-((R)-3-(6-methylpyridine-3-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

47) N-(4-methoxy-2-(4-(4-methylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(6-methylpyridine-3-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

48) N-(4-methoxy-2-(4-(1-methylpiperidine-4-yl)piperazine-1-yl)-5-((6-((R)-3-(6-methylpyridine-3-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

49) N-(2-(4-acetylpiperazine-1-yl)-4-methoxy-5-((6-((R)-3-(6-methylpyridine-3-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

50) N-(2-(4-dimethylaminopiperidine-1-yl)-4-methoxy-5-((6-((R)-3-(6-methylpyridine-3-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

51) N-(2-((1R,4R)-5-ethyl-2,5-diazabicyclo[2.2.1]heptane-2-yl)-4-methoxy-5-((6-((R)-3-(6-methylpyridine-3-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

52) N-(4-methoxy-2-(4-(5-methyl-2,5-diazabicyclo[2.2.1]heptane-2-yl)piperidine-1-yl)-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

53) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

54) N-(2-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

55) N-(2-(4-(4-ethylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

56) N-(2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

57) N-(2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

58) N-(5-((6-((R)-3-(4-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

59) N-(5-((6-((R)-3-(3-chloro-4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

60) N-(2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3,4-dichloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

61) N-(2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

62) N-(5-((6-((R)-3-(3-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

63) N-(5-((6-((R)-3-(4-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

64) N-(2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

65) N-(2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(3-methoxyphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

66) N-(2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

67) N-(2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(6-methylpyridine-3-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

68) N-(2-(4-(4-cyclobutylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

69) N-(2-(4-(4-cyclobutylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(3-methoxyphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

70) N-(5-((6-((R)-3-(3-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-cyclobutylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

71) N-(5-((6-((R)-3-(4-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-cyclobutylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

72) N-(2-(4-(4-cyclobutylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

73) N-(5-((6-((R)-3-(3-chloro-4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-cyclobutylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

74) N-(2-(4-(4-cyclobutylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3,4-dichloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

75) N-(5-((6-((R)-3-(4-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-cyclobutylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

76) N-(2-(4-(4-cyclobutylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

77) N-(2-(4-(4-cyclobutylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

78) N-(2-(4-(4-cyclobutylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(2-fluoro-3-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

79) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-(oxetane-3-yl)piperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

80) N-(5-((6-((R)-3-(3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-(oxetane-3-yl)piperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

81) N-(4-methoxy-5-((6-((R)-3-(3-methoxyphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-(oxetane-3-yl)piperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

82) N-(5-((6-((R)-3-(4-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-(oxetane-3-yl)piperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

83) N-(5-((6-((R)-3-(4-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-(oxetane-3-yl)piperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

84) N-(5-((6-((R)-3-(3,4-dichloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-(oxetane-3-yl)piperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

85) N-(5-((6-((R)-3-(4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-(oxetane-3-yl)piperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

86) N-(5-((6-((R)-3-(3-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-(oxetane-3-yl)piperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

87) N-(2-(4-(4-allylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

88) N-(2-(4-(4-allylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

89) N-(2-(4-(4-allylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3-chloro-4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

90) N-(2-(4-(4-allylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

91) N-(2-(4-(4-(cyclopropylmethyl)piperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

92) N-(2-(4-(4-(cyclopropylmethyl)piperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

93) N-(2-(4-(4-(cyclopropylmethyl)piperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

94) N-(5-((6-((R)-3-(3-chloro-4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-(cyclopropylmethyl)piperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

95) N-(2-(4-(4-(cyclopropylmethyl)piperazine-1-yl)piperidine-1-yl)-5-((6-((S)-3-(2,6-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

96) N-(5-((6-((R)-3-(3-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-(cyclopropylmethyl)piperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

97) N-(2-(4-(4-cyclopentylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

98) N-(2-(4-(4-cyclopentylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

99) N-(5-((6-((R)-3-(3-chloro-4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-cyclopentylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

100) N-(2-(4-(4-cyclopentylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

101) N-(5-((6-((R)-3-(3-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-cyclopentylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

102) N-(4-methoxy-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-(tetrahydro-2H-pyran-4-yl)piperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

103) N-(2-(4-(2-oxa-6-azaspiro[3.3]heptane-6-yl)piperidine-1-yl)-5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

104) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(5-ethylhexahydropyrrolo[3,4-c]pyrrole-2(1H)-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

105) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-((3aR,6aS)-tetrahydro-1H-puro[3,4-c]pyrrole-5(3H)-yl)piperidine-1-yl)phenyl)acrylamide;

106) N-(2-(4-(4-cyclopropyl-3,3-dimethylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

107) N-(2-(4-((2R,5S)-4-cyclopropyl-2,5-dimethylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

108) N-(2-(4-((2S,5R)-4-cyclopropyl-2,5-dimethylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

109) N-(2-(4-((R)-4-cyclopropyl-3-methylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

110) N-(2-(4-((S)-4-cyclopropyl-3-methylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

111) N-(2-(4-((S)-4-cyclopropyl-2-methylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

112) N-(2-(4-((R)-4-cyclopropyl-2-methylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

113) N-(2-(4-((2S,5S)-4-cyclopropyl-2,5-dimethylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

114) N-(2-(4-((2R,5R)-4-cyclopropyl-2,5-dimethylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

115) N-(2-(4-((1R,5S)-8-cyclopropyl-3,8-diazabicyclo[3.2.1]octan-3-yl)piperidine-1-yl)-5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

116) N-(2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-ethoxyphenyl)acrylamide;

117) N-(2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)-(E)-4-(dimethylamino)but-2-enamide;

118) N-(2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-5-((6-((S)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

119) N-(2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-(((R)-1,1,1-trifluoropropane-2-yl)oxy)phenyl)acrylamide;

120) N-(2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)-2-fluoroacrylamide;

121) N-(5-((6-((R)-3-(3-chloro-4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((2S,5S)-4-cyclopropyl-2,5-dimethylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

122) N-(5-((6-((R)-3-(3-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((2R,5R)-4-cyclopropyl-2,5-dimethylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

123) N-(2-(4-((2S,5S)-4-cyclopropyl-2,5-dimethylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(2-fluoro-3-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

124) N-(2-(4-((2R,5R)-4-cyclopropyl-2,5-dimethylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(2-fluoro-3-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

125) N-(5-((6-((R)-3-(3-cyanophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((S)-4-cyclopropyl-3-methylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

126) N-(5-((6-((R)-3-(3-cyanophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((R)-4-cyclopropyl-3-methylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

127) N-(2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(2,3-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

128) N-(5-((6-((R)-3-(3-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((2S,5S)-4-cyclopropyl-2,5-dimethylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

129) N-(2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-5-((6-((S)-3-(2,6-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

130) N-(5-((6-((R)-3-(4-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

131) N-(5-((6-((R)-3-(3-cyanophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((R)-4-cyclopropyl-2-methylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

132) N-(5-((6-((R)-3-(3-cyanophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((S)-4-cyclopropyl-2-methylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

133) N-(5-((6-((R)-3-(3-cyanophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(8-cyclopropyl-3,8-diazabicyclo[3.2.1]octan-3-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

134) N-(2-(4-(8-cyclopropyl-3,8-diazabicyclo[3.2.1]octan-3-yl)piperidine-1-yl)-5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

135) N-(2-(4-(8-cyclopropyl-3,8-diazabicyclo[3.2.1]octan-3-yl)piperidine-1-yl)-5-((6-((R)-3-(2,3-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

136) N-(2-(4-((S)-4-cyclopropyl-3-methylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(2,6-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

137) N-(2-(4-((R)-4-cyclopropyl-3-methylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(2,6-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

138) N-(5-((6-((R)-3-(3-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

139) N-(2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

140) N-(2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(2-fluoro-3-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

141) N-(5-((6-((R)-3-(3-cyanophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

142) N-(5-((6-((R)-3-(2-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(8-cyclopropyl-3,8-diazabicyclo[3.2.1]octan-3-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

143) N-(5-((6-((R)-3-(2-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((R)-4-cyclopropyl-2-methylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

144) N-(5-((6-((R)-3-(2-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((S)-4-cyclopropyl-2-methylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

145) N-(5-((6-((R)-3-(3-chloro-2-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

146) N-(2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(naphthalene-1-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

147) N-(2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(thiophene-2-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

148) N-(2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(3-(trifluoromethyl)phenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

149) N-(5-((6-((R)-3-(3-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((R)-4-cyclopropyl-2-methylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

150) N-(5-((6-((R)-3-(3-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((S)-4-cyclopropyl-2-methylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

151) N-(2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(naphthalene-2-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

152) N-(5-((6-((R)-3-(3-chloro-2-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((R)-4-cyclopropyl-3-methylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

153) N-(5-((6-((R)-3-(3-chloro-2-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((S)-4-cyclopropyl-3-methylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

154) N-(5-((6-((R)-3-(3-chloro-2-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(8-cyclopropyl-3,8-diazabicyclo[3.2.1]octan-3-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

155) N-(2-(4-((R)-4-cyclopropyl-3-methylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(naphthalene-1-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

156) N-(2-(4-((S)-4-cyclopropyl-3-methylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(naphthalene-1-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

157) N-(5-((6-((R)-3-(3-chloro-5-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((S)-4-cyclopropyl-3-methylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

158) N-(5-((6-((R)-3-(3-chloro-5-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((R)-4-cyclopropyl-3-methylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

159) N-(5-((6-((R)-3-(3-chloro-5-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((R)-4-cyclopropyl-2-methylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

160) N-(5-((6-((R)-3-(3-chloro-5-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((S)-4-cyclopropyl-2-methylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

161) N-(2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

162) N-(2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(2,3-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

163) N-(5-((6-((R)-3-(3-chloro-5-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

164) N-(5-((6-((R)-3-(2-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

165) N-(2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3-ethynylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

166) N-(2-(4-((R)-4-cyclopropyl-3-methylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(2,3,6-trifluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

167) N-(2-(4-((S)-4-cyclopropyl-3-methylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(2,3,6-trifluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

168) N-(5-((6-((R)-3-(3-chloro-2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

169) N-(2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(2,3,6-trifluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

170) N-(2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(2,3,4-trifluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

171) N-(2-(4-((2S,5S)-4-cyclopropyl-2,5-dimethylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

172) N-(2-(4-((2R,5R)-4-cyclopropyl-2,5-dimethylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

173) N-(2-(4-((2R,5S)-4-cyclopropyl-2,5-dimethylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

174) N-(2-(4-((2S,5R)-4-cyclopropyl-2,5-dimethylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

175) N-(2-(4-((S)-4-cyclopropyl-3-methylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(2,3-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

176) N-(2-(4-((R)-4-cyclopropyl-3-methylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(2,3-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

177) N-(5-((6-((R)-3-(3-chloro-4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((S)-4-cyclopropyl-3-methylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

178) N-(5-((6-((R)-3-(3-chloro-4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((2R,5R)-4-cyclopropyl-2,5-dimethylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

179) N-(5-((6-((R)-3-(3-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((S)-4-cyclopropyl-3-methylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

180) N-(5-((6-((R)-3-(3-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((R)-4-cyclopropyl-3-methylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

181) N-(5-((6-((R)-3-(3-chloro-4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-cyclopropyl-3,3-dimethylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

182) N-(2-(4-(4-cyclobutylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(2,3-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

183) N-(5-((6-((R)-3-(3-cyanophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-cyclobutylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

184) N-(2-(4-(4-cyclobutylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(naphthalene-1-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

185) N-(5-((6-((R)-3-(3-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-cyclobutylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

186) N-(2-(4-(4-cyclobutylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

187) N-(2-(4-(4-cyclobutylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(2,3,4-trifluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

188) N-(5-((6-((R)-3-(3-chloro-2-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-cyclobutylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

189) N-(5-((6-((R)-3-(3-chloro-5-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-cyclobutylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

190) N-(2-(4-(4-cyclobutylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(naphthalene-2-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

191) N-(2-(4-(4-cyclobutylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3-ethynylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

192) N-(5-((6-((R)-3-(2-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-cyclobutylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

193) N-(5-((6-((R)-3-(3-chloro-2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-cyclobutylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

194) N-(2-(4-(4-cyclobutylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(2,3,6-trifluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

195) N-(5-((6-((R)-3-(2,3-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-(oxetane-3-yl)piperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

196) N-(5-((6-((R)-3-(3-cyanophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-(oxetane-3-yl)piperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

197) N-(5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-(oxetane-3-yl)piperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

198) N-(4-methoxy-5-((6-((R)-3-(naphthalene-1-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-(oxetane-3-yl)piperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

199) N-(5-((6-((R)-3-(3-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-(oxetane-3-yl)piperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

200) N-(4-methoxy-5-((6-((R)-3-(naphthalene-2-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-(oxetane-3-yl)piperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

201) N-(5-((6-((R)-3-(2-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-(oxetane-3-yl)piperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

202) N-(5-((6-((R)-3-(3-chloro-2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-(oxetane-3-yl)piperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

203) N-(2-(4-(4-(cyclopropylmethyl)piperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

204) N-(2-(4-(4-(cyclopropylmethyl)piperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(2,3-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

205) N-(2-(4-(4-cyclopentylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

206) N-(2-(4-(4-cyclopentylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(2,3-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

207) N-(5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-(tetrahydro-2H-pyran-4-yl)piperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

208) N-(5-((6-((R)-3-(2,3-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-(tetrahydro-2H-pyran-4-yl)piperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

209) N-(2-(4-(4-allylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(2,3-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

210) N-(2-(4-(4-allylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3-cyanophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

211) N-(2-(4-(4-allylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(4-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

212) N-(2-(4-(4-allylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

213) N-(2-(4-(4-allylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3-chloro-2-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

214) N-(2-(4-(4-allylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3-chloro-5-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

215) N-(2-(4-(4-allylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(3-methoxyphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

216) N-(2-(4-(4-allylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3-ethynylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

217) N-(2-((1S,4S)-5-ethyl-2,5-diazabicyclo[2.2.1]heptane-2-yl)-4-methoxy-5-((6-((R)-3-(6-methylpyridine-3-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

218) N-(4-methoxy-5-((6-((R)-3-(6-methylpyridine-3-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(oxetane-3-yl)piperazine-1-yl)phenyl)acrylamide;

219) N-(2-(4-(2-(dimethylamino)ethyl)piperazine-1-yl)-4-methoxy-5-((6-((R)-3-(6-methylpyridine-3-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

220) N-(2-(4-isopropylpiperazine-1-yl)-4-methoxy-5-((6-((R)-3-(6-methylpyridine-3-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

221) N-(2-((R)-3-(dimethylamino)pyrolidine-1-yl)-4-methoxy-5-((6-((R)-3-(6-methylpyridine-3-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

222) N-(2-((S)-3-(dimethylamino)pyrolidine-1-yl)-4-methoxy-5-((6-((R)-3-(6-methylpyridine-3-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

223) N-(4-methoxy-2-((2-methoxyethyl)(methyl)amino)-5-((6-((R)-3-(6-methylpyridine-3-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

224) N-(2-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)-4-methoxy-5-((6-((R)-3-(6-methylpyridine-3-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

225) N-(2-(4-cyclopentylpiperazine-1-yl)-4-methoxy-5-((6-((R)-3-(6-methylpyridine-3-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

226) N-(2-(4-cyclopentylpiperazine-1-yl)-4-methoxy-5-((6-((R)-3-(6-methylpyridine-3-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

227) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(6-methylpyridine-3-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

228) N-(2-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(6-methylpyridine-3-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

229) N-(4-methoxy-2-(4-((2-methoxyethyl)(methyl)amino)piperidine-1-yl)-5-((6-((R)-3-(6-methylpyridine-3-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

230) N-(2-(4-(4-isopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(6-methylpyridine-3-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

231) N-(2-(4-((R)-3-(dimethylamino)pyrolidine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(6-methylpyridine-3-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

232) N-(2-(4-(4-acetylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(6-methylpyridine-3-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

233) N-(2-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)-4-methoxy-5-((6-((R)-3-(6-methylpyridine-3-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

234) N-(4-methoxy-2-(4-((1R,4R)-5-methyl-2,5-diazabicyclo[2.2.1]heptane-2-yl)piperidine-1-yl)-5-((6-((R)-3-(6-methylpyridine-3-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

235) N-(4-methoxy-5-((6-((R)-3-(6-methylpyridine-3-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-morpholino-[1,4′-bipiperidine]-1′-yl)phenyl)acrylamide;

236) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-ethylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

237) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((R)-3-(dimethylamino)pyrolidine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

238) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

239) N-(2-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

240) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-ethylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

241) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(dimethylamino)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

242) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((R)-3-(dimethylamino)pyrolidine-1-yl)-4-methoxyphenyl)acrylamide;

243) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((R)-3-(3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

244) N-(2-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((R)-3-(3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

245) N-(2-(4-(dimethylamino)piperidine-1-yl)-5-((6-((R)-3-(3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

246) N-(2-(4-ethylpiperazine-1-yl)-5-((6-((R)-3-(3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

247) N-(2-((R)-3-(dimethylamino)pyrolidine-1-yl)-5-((6-((R)-3-(3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

248) N-(2-(4-(4-ethylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

249) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(3-ethyl-3,6-diazabicyclo[3.1.1]heptane-6-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

250) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((S)-3-(dimethylamino)pyrolidine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

251) N-(2-(4-(4-acetylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

252) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(6-ethyl-3,6-diazabicyclo[3.1.1]heptane-3-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

253) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-4-(dimethylamino)-1,4′-bipiperidine-1′-yl)-4-methoxyphenyl)acrylamide;

254) N-(5-((6-((R)-3-(4-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-ethylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

255) N-(5-((6-((R)-3-(4-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-ethylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

256) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((R)-3-(4-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

257) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((R)-3-(3-chloro-4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

258) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((R)-3-(3-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

259) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

260) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptane-2-yl)piperidine-1-yl)phenyl)acrylamide;

261) N-(2-(4-(4-ethylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-(3-methyl-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

262) N-(5-((6-((R)-3-(4-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-ethylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

263) N-(5-((6-((R)-3-(3-chloro-4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-ethylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

264) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((1S,4S)-5-ethyl-2,5-diazabicyclo[2.2.1]heptane-2-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

265) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-isopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

266) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((2S,6R)-2,6-dimethylmorpholino)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

267) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((1R,4R)-5-ethyl-2,5-diazabicyclo[2.2.1]heptane-2-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

268) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((R)-3-(3,4-dichloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

269) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-4-methoxy-5-((6-((S)-3-methyl-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

270) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-methyl-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

271) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((R)-3-morpholinopyrolidine-1-yl)phenyl)acrylamide;

272) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((S)-3-morpholinopyrolidine-1-yl)phenyl)acrylamide;

273) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(oxetane-3-yl)piperazine-1-yl)phenyl)acrylamide;

274) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-methyl-3-oxopiperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

275) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((1-isopropylpiperidine-4-yl)amino)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

276) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((2-(dimethylamino)ethyl)(methyl)amino)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

277) N-(2-(4-(cyclopropylmethyl)piperazine-1-yl)-4-methoxy-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

278) N-(2-(4-(2-(dimethylamino)ethyl)piperazine-1-yl)-4-methoxy-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

279) N-(2-(4-cyclopentylpiperazine-1-yl)-4-methoxy-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

280) N-(2-((1R,4R)-5-ethyl-2,5-diazabicyclo[2.2.1]heptane-2-yl)-4-methoxy-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

281) N-(2-((1S,4S)-5-ethyl-2,5-diazabicyclo[2.2.1]heptane-2-yl)-4-methoxy-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

282) N-(4-methoxy-2-(4-methyl-1H-imidazole-1-yl)-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

283) N-(2-(4-(4-isopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

284) N-(2-(4-(4-acetylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

285) N-(2-(4-((2S,6R)-2,6-dimethylmorpholino)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

286) N-(2-(4-((S)-3-(dimethylamino)pyrolidine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

287) N-(5-((6-((R)-3-(3,4-dichloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(oxetane-3-yl)piperazine-1-yl)phenyl)acrylamide;

288) N-(5-((6-((R)-3-(3,4-dichloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide;

289) N-(5-((6-((R)-3-(3,4-dichloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-methylpiperazine-1-yl)phenyl)acrylamide;

290) N-(5-((6-((R)-3-(3,4-dichloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(dimethylamino)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

291) N-(5-((6-((R)-3-(3,4-dichloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((R)-3-(dimethylamino)pyrolidine-1-yl)-4-methoxyphenyl)acrylamide;

292) N-(5-((6-((R)-3-(3,4-dichloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-ethylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

293) N-(5-((6-((R)-3-(3,4-dichloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-ethylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

294) N-(5-((6-((R)-3-(3,4-dichloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((R)-3-morpholinopyrolidine-1-yl)phenyl)acrylamide;

295) N-(5-((6-((R)-3-(3,4-dichloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((S)-3-morpholinopyrolidine-1-yl)phenyl)acrylamide;

296) N-(5-((6-((R)-3-(4-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(oxetane-3-yl)piperazine-1-yl)phenyl)acrylamide;

297) N-(5-((6-((R)-3-(2,3-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-ethylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

298) N-(2-(4-acetylpiperazine-1-yl)-5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

299) N-(2-(4-cyclopropylpiperazine-1-yl)-5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

300) N-(5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-propylpiperazine-1-yl)phenyl)acrylamide;

301) N-(5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((S)-3-(dimethylamino)pyrolidine-1-yl)-4-methoxyphenyl)acrylamide;

302) N-(5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((S)-3-morpholinopyrolidine-1-yl)phenyl)acrylamide;

303) N-(5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-isopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

304) N-(5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((R)-3-(dimethylamino)pyrolidine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

305) N-(5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(dimethylamino)-(1,4′-bipiperidine)-1′-yl)-4-methoxyphenyl)acrylamide;

306) N-(5-((6-((S)-3-(2,6-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide;

307) N-(5-((6-((S)-3-(2,6-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-methylpiperazine-1-yl)phenyl)acrylamide;

308) N-(5-((6-((S)-3-(2,6-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(dimethylamino)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

309) N-(5-((6-((S)-3-(2,6-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((2S,6R)-2,6-dimethylmorpholino)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

310) N-(2-(4-(4-acetylpiperazine-1-yl)piperidine-1-yl)-5-((6-((S)-3-(2,6-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

311) N-(5-((6-((S)-3-(2,6-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-isopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

312) N-(5-((6-((S)-3-(2,6-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-ethylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

313) N-(5-((6-((S)-3-(2,6-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((S)-3,4-dimethylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

314) N-(5-((6-((S)-3-(2,6-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((R)-3-(dimethylamino)pyrolidine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

315) N-(5-((6-((S)-3-(2,6-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((S)-3-(dimethylamino)pyrolidine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

316) N-(5-((6-((R)-3-(3-chloro-4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((3aS,6aS)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-yl)phenyl)acrylamide;

317) N-(5-((6-((R)-3-(3-chloro-4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((3aR,6aR)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-yl)phenyl)acrylamide;

318) N-(2-(4-(4-ethylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(2-fluoro-3-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

319) N-(5-((6-((R)-3-(2-fluoro-3-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((2-methoxyethyl)(methyl)amino)phenyl)acrylamide;

320) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((R)-3-(2-fluoro-3-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

321) N-(5-((6-((R)-3-(3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((S)-3-morpholinopyrolidine-1-yl)phenyl)acrylamide;

322) N-(2-(4-((1R,5S)-8-oxa-3-azabicyclo[3.2.1]octan-3-yl)piperidine-1-yl)-5-((6-((R)-3-(3-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

323) N-(5-((6-((R)-3-(3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((R)-3-morpholinopyrolidine-1-yl)phenyl)acrylamide;

324) N-(2-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)-5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

325) N-(5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-morpholinophenyl)acrylamide;

326) N-(5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-methylpiperazine-1-yl)phenyl)acrylamide;

327) N-(5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((2-methoxyethyl)(methyl)amino)phenyl)acrylamide;

328) N-(2-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)-5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

329) N-(2-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)-5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

330) N-(5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(2-methyl-1H-imidazole-1-yl)phenyl)acrylamide;

331) N-(5-((6-((R)-3-(3-cyanophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((3aR,6aR)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-yl)phenyl)acrylamide;

332) N-(5-((6-((R)-3-(3-cyanophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((3aS,6aS)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-yl)phenyl)acrylamide;

333) N-(2-(4-cyclopropylpiperazine-1-yl)-5-((6-((R)-3-(2,3-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

334) N-(5-((6-((R)-3-(2,3-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-isopropylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

335) N-(5-((6-((R)-3-(2,3-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((S)-3,4-dimethylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

336) N-(5-((6-((R)-3-(2,3-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((R)-3,4-dimethylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

337) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((S)-2-methylmorpholino)phenyl)acrylamide;

338) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((R)-2-methylmorpholino)phenyl)acrylamide;

339) N-(2-(4-(4-acetylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(2,3-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

340) N-(5-((6-((R)-3-(2,3-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((S)-3-(dimethylamino)pyrolidine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

341) N-(2-(4,4-difluoro-[1,4′-bipiperidine]-1′-yl)-5-((6-((R)-3-(2,3-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

342) N-(5-((6-((R)-3-(2,3-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-propylpiperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

343) N-(2-(4-acetylpiperazine-1-yl)-5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

344) N-(2-(4-cyclopropylpiperazine-1-yl)-5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

345) N-(5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(1-methylpiperidine-4-yl)piperazine-1-yl)phenyl)acrylamide;

346) N-(5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-isopropylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

347) N-(5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((2-methoxyethyl)(methyl)amino)phenyl)acrylamide;

348) N-(2-(4-cyclopentylpiperazine-1-yl)-5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

349) N-(5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(2-(dimethylamino)ethyl)piperazine-1-yl)-4-methoxyphenyl)acrylamide;

350) N-(5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide;

351) N-(5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-ethylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

352) N-(5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-methylpiperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

353) N-(2-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)-5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

354) N-(5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((1S,4S)-5-ethyl-2,5-diazabicyclo[2.2.1]heptane-2-yl)-4-methoxyphenyl)acrylamide;

355) N-(2-(4-(6-azaspiro[2.5]octan-6-yl)piperidine-1-yl)-5-((6-((R)-3-(3-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

356) N-(5-((6-((R)-3-(3-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-((S)-2-methylmorpholino)piperidine-1-yl)phenyl)acrylamide;

357) N-(5-((6-((R)-3-(3-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-((R)-2-methylmorpholino)piperidine-1-yl)phenyl)acrylamide;

358) N-(5-((6-((R)-3-(3-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-cyclopropyl-1,4-diazepane-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

359) N-(5-((6-((R)-3-(3-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide;

360) N-(5-((6-((R)-3-(3-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-methylpiperazine-1-yl)phenyl)acrylamide;

361) N-(5-((6-((R)-3-(3-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(dimethylamino)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

362) N-(2-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((R)-3-(2-fluoro-3-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

363) N-(2-(4-acetylpiperazine-1-yl)-5-((6-((R)-3-(4-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

364) N-(5-((6-((R)-3-(4-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-cyclopropylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

365) N-(5-((6-((R)-3-(4-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((S)-3-morpholinopyrolidine-1-yl)phenyl)acrylamide;

366) N-(5-((6-((S)-3-(2,6-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((R)-3-(dimethylamino)pyrolidine-1-yl)-4-methoxyphenyl)acrylamide;

367) N-(5-((6-((S)-3-(2,6-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((R)-3-morpholinopyrolidine-1-yl)phenyl)acrylamide;

368) N-(5-((6-((S)-3-(2,6-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((S)-3-morpholinopyrolidine-1-yl)phenyl)acrylamide;

369) N-(5-((6-((S)-3-(2,6-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(dimethylamino)-[1,4′-bipiperidine]-1′-yl)-4-methoxyphenyl)acrylamide;

370) N-(5-((6-((R)-3-(3-chloro-4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((3S,5R)-4-ethyl-3,5-dimethylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

371) N-(5-((6-((R)-3-(4-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide;

372) N-(5-((6-((R)-3-(4-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-methylpiperazine-1-yl)phenyl)acrylamide;

373) N-(2-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((R)-3-(4-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

374) N-(5-((6-((R)-3-(4-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((2S,6R)-2,6-dimethylmorpholino)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

375) N-(2-(4-(4-acetylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(4-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

376) N-(5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((R)-3-(dimethylamino)pyrolidine-1-yl)-4-methoxyphenyl)acrylamide;

377) N-(5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(5-methyl-1H-imidazole-1-yl)phenyl)acrylamide;

378) N-(5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-morpholinopiperidine-1-yl)phenyl)acrylamide;

379) N-(5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(tetrahydro-2H-pyran-4-yl)piperazine-1-yl)phenyl)acrylamide;

380) N-(2-(4-(cyclopropylmethyl)piperazine-1-yl)-5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

381) N-(2-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

382) N-(5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((1S,4S)-5-ethyl-2,5-diazabicyclo[2.2.1]heptane-2-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

383) N-(5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(oxetane-3-yl)piperazine-1-yl)phenyl)acrylamide;

384) N-(5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(dimethylamino)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

385) N-(5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((1R,4R)-5-ethyl-2,5-diazabicyclo[2.2.1]heptane-2-yl)-4-methoxyphenyl)acrylamide;

386) N-(5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-methyl-1H-imidazole-1-yl)phenyl)acrylamide;

387) N-(5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-((2-methoxyethyl)(methyl)amino)piperidine-1-yl)phenyl)acrylamide;

388) N-(5-((6-((R)-3-(3-cyanophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-((R)-3-methylmorpholino)piperidine-1-yl)phenyl)acrylamide;

389) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((R)-3-(3-cyanophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

390) N-(5-((6-((R)-3-(3-cyanophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-hydroxypiperidine-1-yl)-4-methoxyphenyl)acrylamide;

391) N-(5-((6-((R)-3-(3-cyanophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(oxetane-3-yl)piperazine-1-yl)phenyl)acrylamide;

392) N-(5-((6-((R)-3-(3-cyanophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide;

393) N-(5-((6-((R)-3-(3-cyanophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-methylpiperazine-1-yl)phenyl)acrylamide;

394) N-(5-((6-((R)-3-(3-cyanophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(dimethylamino)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

395) N-(5-((6-((R)-3-(3-cyanophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((R)-3-(dimethylamino)pyrolidine-1-yl)-4-methoxyphenyl)acrylamide;

396) N-(5-((6-((R)-3-(3-cyanophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-ethylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

397) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-morpholinophenyl)-(E)-4-(dimethylamino)but-2-enamide;

398) N-(5-((6-((R)-3-(3-cyanophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-methylpiperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

399) N-(5-((6-((R)-3-(3-cyanophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-ethylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

400) N-(5-((6-((R)-3-(3-cyanophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-morpholinopiperidine-1-yl)phenyl)acrylamide;

401) N-(5-((6-((R)-3-(4-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-ethylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

402) N-(1-(2-acrylamido-4-((6-((R)-3-(4-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-5-methoxyphenyl)piperidine-4-yl)-N-(1-isopropylpiperidine-4-yl)acrylamide;

403) N-(5-((6-((R)-3-(4-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(dimethylamino)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

404) N-(5-((6-((R)-3-(4-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((R)-3-(dimethylamino)pyrolidine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

405) N-(5-((6-((R)-3-(4-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((S)-3-(dimethylamino)pyrolidine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

406) N-(5-((6-((R)-3-(4-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((R)-3-morpholinopyrolidine-1-yl)phenyl)acrylamide;

407) N-(5-((6-((R)-3-(4-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((S)-3-morpholinopyrolidine-1-yl)phenyl)acrylamide;

408) N-(5-((6-((R)-3-(4-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-isopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

409) N-(5-((6-((R)-3-(4-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-ethylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

410) N-(5-((6-((R)-3-(4-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(dimethylamino)-[1,4′-bipiperidine]-1′-yl)-4-methoxyphenyl)acrylamide;

411) N-(5-((6-((R)-3-(3-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-ethylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

412) N-(5-((6-((R)-3-(3-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-ethylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

413) N-(5-((6-((R)-3-(3-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((R)-3-(dimethylamino)pyrolidine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

414) N-(5-((6-((R)-3-(3-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(dimethylamino)-[1,4′-bipiperidine]-1′-yl)-4-methoxyphenyl)acrylamide;

415) N-(5-((6-((R)-3-(3-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((2S,6R)-2,6-dimethylmorpholino)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

416) N-(5-((6-((R)-3-(3-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-methylpiperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

417) N-(5-((6-((R)-3-(3-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-morpholinopiperidine-1-yl)phenyl)acrylamide;

418) N-(2-(4-((R)-3-(dimethylamino)pyrolidine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(2-fluoro-3-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

419) N-(5-((6-((R)-3-(4-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((R)-3-morpholinopyrolidine-1-yl)phenyl)acrylamide;

420) N-(2-(4-(dimethylamino)-[1,4′-bipiperidine]-1′-yl)-5-((6-((R)-3-(2-fluoro-3-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

421) N-(2-(4-(4-acetylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(2-fluoro-3-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

422) N-(5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((2-(dimethylamino)ethyl)(methyl)amino)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

423) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

424) N-(5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-ethylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

425) N-(5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((1R,4R)-5-ethyl-2,5-diazabicyclo[2.2.1]heptane-2-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

426) N-(5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-morpholino-[1,4′-bipiperidine]-1′-yl)phenyl)acrylamide;

427) N-(2-(4-(4-acetylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

428) N-(5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-isopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

429) N-(5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((R)-3-(dimethylamino)pyrolidine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

430) N-(5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-(1-methylpiperidine-4-yl)piperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

431) N-(5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-(2-(dimethylamino)ethyl)piperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

432) N-(5-((6-((R)-3-(3-cyanophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-propylpiperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

433) N-(5-((6-((R)-3-(3-cyanophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4,4-difluoro-[1,4′-bipiperidine]-1′-yl)-4-methoxyphenyl)acrylamide;

434) N-(2-(4-(4-acetylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3-cyanophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

435) N-(5-((6-((R)-3-(3-cyanophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((S)-3-(dimethylamino)pyrolidine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

436) N-(2-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)-5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

437) N-(2-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)-5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

438) N-(2-(4-cyclopropylpiperazine-1-yl)-5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

439) N-(4-methoxy-5-((6-((R)-3-(naphthalene-1-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(oxetane-3-yl)piperazine-1-yl)phenyl)acrylamide;

440) N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((6-((R)-3-(naphthalene-1-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

441) N-(4-methoxy-2-(4-methylpiperazine-1-yl)-5-((6-((R)-3-(naphthalene-1-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

442) N-(2-(4-(dimethylamino)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(naphthalene-1-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

443) N-(2-((R)-3-(dimethylamino)pyrolidine-1-yl)-4-methoxy-5-((6-((R)-3-(naphthalene-1-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

444) N-(2-(4-ethylpiperazine-1-yl)-4-methoxy-5-((6-((R)-3-(naphthalene-1-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

445) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-((3aR,6aR)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-yl)piperidine-1-yl)phenyl)acrylamide;

446) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-((3aS,6aS)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-yl)piperidine-1-yl)phenyl)acrylamide;

447) N-(5-((6-((R)-3-(2-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-((3aR,6aR)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-yl)piperidine-1-yl)phenyl)acrylamide;

448) N-(5-((6-((R)-3-(2-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-((3aS,6aS)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-yl)piperidine-1-yl)phenyl)acrylamide;

449) N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((6-((R)-3-(3-(trifluoromethyl)phenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

450) N-(4-methoxy-2-(4-methylpiperazine-1-yl)-5-((6-((R)-3-(3-(trifluoromethyl)phenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

451) N-(2-(4-(dimethylamino)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(3-(trifluoromethyl)phenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

452) N-(2-(4-ethylpiperazine-1-yl)-4-methoxy-5-((6-((R)-3-(3-(trifluoromethyl)phenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

453) N-(4-methoxy-2-(4-(4-methylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3-(trifluoromethyl)phenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

454) N-(5-((6-((R)-3-(4-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-methylpiperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

455) N-(5-((6-((R)-3-(4-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-morpholinopiperidine-1-yl)phenyl)acrylamide;

456) N-(5-((6-((R)-3-(4-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((R)-3-(dimethylamino)pyrolidine-1-yl)-4-methoxyphenyl)acrylamide;

457) N-(5-((6-((R)-3-(3,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide;

458) N-(5-((6-((R)-3-(3,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-methylpiperazine-1-yl)phenyl)acrylamide;

459) N-(5-((6-((R)-3-(3,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(dimethylamino)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

460) N-(5-((6-((R)-3-(3,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-ethylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

461) N-(5-((6-((R)-3-(3-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-isopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

462) N-(2-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((R)-3-(3-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

463) N-(5-((6-((R)-3-(3-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-cyclopropylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

464) N-(2-(4-acetylpiperazine-1-yl)-5-((6-((R)-3-(3-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

465) N-(5-((6-((R)-3-(3-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((R)-3-morpholinopyrolidine-1-yl)phenyl)acrylamide;

466) N-(2-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)-5-((6-((R)-3-(3-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

467) N-(5-((6-((R)-3-(3-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-morpholinophenyl)acrylamide;

468) N-(5-((6-((R)-3-(3-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((S)-3-(dimethylamino)pyrolidine-1-yl)-4-methoxyphenyl)acrylamide;

469) N-(5-((6-((R)-3-(3-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((R)-3-(dimethylamino)pyrolidine-1-yl)-4-methoxyphenyl)acrylamide;

470) N-(5-((6-((R)-3-(3-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(oxetane-3-yl)piperazine-1-yl)phenyl)acrylamide;

471) N-(2-(4-(4-acetylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

472) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((R)-3-(3-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

473) N-(5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-((1R,4R)-5-methyl-2,5-diazabicyclo[2.2.1]heptane-2-yl)piperidine-1-yl)phenyl)acrylamide;

474) N-(2-((S)-4-cyclopropyl-2-methylpiperazine-1-yl)-5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

475) N-(5-((6-((R)-3-(2,3-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-isopropylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

476) N-(5-((6-((R)-3-(2,3-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(dimethylamino)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

477) N-(5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-methylpiperazine-1-yl)-[1,4′-bipiperidine]-1′-yl)phenyl)acrylamide;

478) N-(5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(dimethylamino)-[1,4′-bipiperidine]-1′-yl)-4-methoxyphenyl)acrylamide;

479) N-(2-((S)-4-cyclopropyl-3-methylpiperazine-1-yl)-5-((6-((R)-3-(2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

480) N-(5-((6-((R)-3-(2,3-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-ethylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

481) N-(5-((6-((R)-3-(2,3-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-methylpiperazine-1-yl)phenyl)acrylamide;

482) N-(4-methoxy-2-(4-(4-methylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(naphthalene-1-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

483) N-(4-methoxy-2-(4-morpholinopiperidine-1-yl)-5-((6-((R)-3-(naphthalene-1-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

484) N-(2-(4-(4-ethylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(naphthalene-1-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

485) N-(5-((6-((R)-3-(3-chloro-2-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-methylpiperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

486) N-(5-((6-((R)-3-(3-chloro-2-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-morpholinopiperidine-1-yl)phenyl)acrylamide;

487) N-(5-((6-((R)-3-(3-chloro-2-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-ethylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

488) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(naphthalene-1-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

489) N-(2-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(naphthalene-1-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

490) N-(2-(4-(4-isopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(naphthalene-1-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

491) N-(2-(4-((2S,6R)-2,6-dimethylmorpholino)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(naphthalene-1-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

492) N-(5-((6-((R)-3-(3-cyanophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((R)-3-(dimethylamino)pyrolidine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

493) N-(2-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((R)-3-(3-cyanophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

494) N-(5-((6-((R)-3-(3-cyanophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-isopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

495) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(3-methoxy-3-methylbutoxy)phenyl)acrylamide;

496) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(3-methoxy-3-methylbutoxy)phenyl)-(E)-4-(dimethylamino)but-2-enamide;

497) N-(2-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((R)-3-(3,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

498) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((R)-3-(3,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

499) N-(5-((6-((R)-3-(3,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((R)-3-(dimethylamino)pyrolidine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

500) N-(5-((6-((R)-3-(3,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((S)-3-(dimethylamino)pyrolidine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

501) N-(5-((6-((R)-3-(3,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-isopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

502) N-(5-((6-((R)-3-(3,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-methylpiperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

503) N-(5-((6-((R)-3-(3,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-morpholinopiperidine-1-yl)phenyl)acrylamide;

504) N-(4-methoxy-2-(4-morpholinopiperidine-1-yl)-5-((6-((R)-3-(3-(trifluoromethyl)phenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

505) N-(2-((R)-3-(dimethylamino)pyrolidine-1-yl)-4-methoxy-5-((6-((R)-3-(3-(trifluoromethyl)phenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

506) N-(4-methoxy-2-((R)-3-morpholinopyrolidine-1-yl)-5-((6-((R)-3-(3-(trifluoromethyl)phenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

507) N-(4-methoxy-2-((S)-3-morpholinopyrolidine-1-yl)-5-((6-((R)-3-(3-(trifluoromethyl)phenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

508) N-(5-((6-((R)-3-(3-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((S)-3-(dimethylamino)pyrolidine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

509) N-(4-methoxy-2-(4-methylpiperazine-1-yl)-5-((6-((R)-3-(naphthalene-2-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

510) N-(2-(4-(dimethylamino)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(naphthalene-2-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

511) N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((6-((R)-3-(naphthalene-2-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

512) N-(2-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(naphthalene-2-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

513) N-(2-((R)-3-(dimethylamino)pyrolidine-1-yl)-4-methoxy-5-((6-((R)-3-(naphthalene-2-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

514) N-(2-(4-ethylpiperazine-1-yl)-4-methoxy-5-((6-((R)-3-(naphthalene-2-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

515) N-(2-(4-(4-ethylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(naphthalene-2-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

516) N-(5-((6-((R)-3-(2,3-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide;

517) N-(5-((6-((R)-3-(2,3-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-morpholinophenyl)acrylamide;

518) N-(2-(4-cyclopropylpiperazine-1-yl)-5-((6-((R)-3-(2,3-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

519) N-(2-(4-acetylpiperazine-1-yl)-5-((6-((R)-3-(2,3-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

520) N-(5-((6-((R)-3-(2,3-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(oxetane-3-yl)piperazine-1-yl)phenyl)acrylamide;

521) N-(5-((6-((R)-3-(2,3-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-morpholinopiperidine-1-yl)phenyl)acrylamide;

522) N-(2-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)-5-((6-((R)-3-(2,3-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

523) N-(2-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)-5-((6-((R)-3-(2,3-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

524) N-(5-((6-((R)-3-(2,3-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((1S,4S)-5-ethyl-2,5-diazabicyclo[2.2.1]heptane-2-yl)-4-methoxyphenyl)acrylamide;

525) N-(5-((6-((R)-3-(2,3-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((1R,4R)-5-ethyl-2,5-diazabicyclo[2.2.1]heptane-2-yl)-4-methoxyphenyl)acrylamide;

526) N-(5-((6-((R)-3-(2,3-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((R)-3-(dimethylamino)pyrolidine-1-yl)-4-methoxyphenyl)acrylamide;

527) N-(5-((6-((R)-3-(2,3-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-methyl-1H-imidazole-1-yl)phenyl)acrylamide;

528) N-(5-((6-((R)-3-(3-chloro-2-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((2S,6R)-2,6-dimethylmorpholino)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

529) N-(5-((6-((R)-3-(3-chloro-2-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-((S)-2-methylmorpholino)piperidine-1-yl)phenyl)acrylamide;

530) N-(5-((6-((R)-3-(3-chloro-2-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-((R)-2-methylmorpholino)piperidine-1-yl)phenyl)acrylamide;

531) N-(2-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((R)-3-(3-chloro-2-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

532) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((R)-3-(3-chloro-2-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

533) N-(2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-fluorophenyl)acrylamide;

534) N-(2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methylphenyl)acrylamide;

535) N-(4-methoxy-2-(4-((S)-2-methylmorpholino)piperidine-1-yl)-5-((6-((R)-3-(naphthalene-1-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

536) N-(4-methoxy-2-(4-((R)-2-methylmorpholino)piperidine-1-yl)-5-((6-((R)-3-(naphthalene-1-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

537) N-(5-((6-((R)-3-(3-chloro-5-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-methylpiperazine-1-yl)phenyl)acrylamide;

538) N-(5-((6-((R)-3-(3-chloro-5-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide;

539) N-(5-((6-((R)-3-(3-chloro-5-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-((3aR,6aR)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-yl)piperidine-1-yl)phenyl)acrylamide;

540) N-(5-((6-((R)-3-(3-chloro-5-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-((3aS,6aS)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-yl)piperidine-1-yl)phenyl)acrylamide;

541) N-(5-((6-((R)-3-(4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-((3aR,6aR)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-yl)piperidine-1-yl)phenyl)acrylamide;

542) N-(5-((6-((R)-3-(3,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(3-methyl-3,6-diazabicyclo[3.1.1]heptane-6-yl)phenyl)acrylamide;

543) N-(5-((6-((R)-3-(3,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((2S,6R)-2,6-dimethylmorpholino)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

544) N-(2-(4-(4-acetylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

545) N-(5-((6-((R)-3-(3,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-ethylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

546) N-(5-((6-((R)-3-(3,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(dimethylamino)-[1,4′-bipiperidine]-1′-yl)-4-methoxyphenyl)acrylamide;

547) N-(5-((6-((R)-3-(3,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-propylpiperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

548) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((R)-3-(4-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

549) N-(4-methoxy-5-((6-((R)-3-(3-methoxyphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-propylpiperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

550) N-(2-(4-(4-isopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(naphthalene-2-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

551) N-(5-((6-((R)-3-(2-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide;

552) N-(5-((6-((R)-3-(2-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-methylpiperazine-1-yl)phenyl)acrylamide;

553) N-(5-((6-((R)-3-(2-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(dimethylamino)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

554) N-(4-methoxy-2-(4-(4-methylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(naphthalene-2-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

555) N-(4-methoxy-2-(4-morpholinopiperidine-1-yl)-5-((6-((R)-3-(naphthalene-2-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

556) N-(2-(4-(4-acetylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(naphthalene-2-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

557) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(naphthalene-2-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

558) N-(5-((6-((R)-3-(2-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((R)-3-(dimethylamino)pyrolidine-1-yl)-4-methoxyphenyl)acrylamide;

559) N-(5-((6-((R)-3-(2-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-ethylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

560) N-(5-((6-((R)-3-(2-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-methylpiperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

561) N-(5-((6-((R)-3-(2,3-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(tetrahydro-2H-pyran-4-yl)piperazine-1-yl)phenyl)acrylamide;

562) N-(5-((6-((R)-3-(2,3-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(1-methylpiperidine-4-yl)piperazine-1-yl)phenyl)acrylamide;

563) N-(2-(4-cyclopentylpiperazine-1-yl)-5-((6-((R)-3-(2,3-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

564) N-(2-((R)-4-cyclopropyl-3-methylpiperazine-1-yl)-5-((6-((R)-3-(2,3-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

565) N-(5-((6-((R)-3-(2,3-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-methylpiperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

566) N-(5-((6-((R)-3-(2,3-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(2-(dimethylamino)ethyl)piperazine-1-yl)-4-methoxyphenyl)acrylamide;

567) N-(2-(4-(cyclopropylmethyl)piperazine-1-yl)-5-((6-((R)-3-(2,3-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

568) N-(2-((S)-4-cyclopropyl-3-methylpiperazine-1-yl)-5-((6-((R)-3-(2,3-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

569) N-(5-((6-((R)-3-(2,3-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-ethylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

570) N-(2-(4-ethylpiperazine-1-yl)-4-methoxy-5-((6-((R)-3-(2,3,4-trifluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

571) N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((6-((R)-3-(2,3,4-trifluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

572) N-(4-methoxy-2-(4-methylpiperazine-1-yl)-5-((6-((R)-3-(2,3,4-trifluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

573) N-(2-(4-(dimethylamino)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(2,3,4-trifluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

574) N-(2-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(2,3,4-trifluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

575) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(2,3,4-trifluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

576) N-(2-(4-((2S,6R)-2,6-dimethylmorpholino)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(2,3,4-trifluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

577) N-(5-((6-((R)-3-(3,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((R)-3-(dimethylamino)pyrolidine-1-yl)-4-methoxyphenyl)acrylamide;

578) N-(5-((6-((R)-3-(3,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((R)-3-morpholinopyrolidine-1-yl)phenyl)acrylamide;

579) N-(5-((6-((R)-3-(3,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((S)-3-morpholinopyrolidine-1-yl)phenyl)acrylamide;

580) N-(5-((6-((R)-3-(3-chloro-2-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-isopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

581) N-(5-((6-((R)-3-(3-chloro-2-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4,4-difluoro-[1,4′-bipiperidine]-1′-yl)-4-methoxyphenyl)acrylamide;

582) N-(5-((6-((R)-3-(3-chloro-2-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-propylpiperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

583) N-(5-((6-((R)-3-(3-chloro-2-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide;

584) N-(5-((6-((R)-3-(3-chloro-2-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-methylpiperazine-1-yl)phenyl)acrylamide;

585) N-(5-((6-((R)-3-(3-chloro-2-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-ethylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

586) N-(5-((6-((R)-3-(3-chloro-2-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((R)-3-(dimethylamino)pyrolidine-1-yl)-4-methoxyphenyl)acrylamide;

587) N-(5-((6-((R)-3-(3-chloro-5-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(3-(4-cyclopropylpiperazine-1-yl)azetidine-1-yl)-4-methoxyphenyl)acrylamide;

588) N-(2-(3-(4-cyclopropylpiperazine-1-yl)azetidine-1-yl)-5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

589) N-(5-((6-((R)-3-(3-chloro-5-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-morpholinopiperidine-1-yl)phenyl)acrylamide;

590) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((R)-3-(3-chloro-5-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

591) N-(5-((6-((R)-3-(3-chloro-5-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-hydroxypiperidine-1-yl)-4-methoxyphenyl)acrylamide;

592) N-(2-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((R)-3-(3-chloro-5-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

593) N-(5-((6-((R)-3-(3-chloro-5-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-isopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

594) N-(5-((6-((R)-3-(3-chloro-5-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((2S,6R)-2,6-dimethylmorpholino)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

595) N-(5-((6-((R)-3-(3-chloro-5-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-((S)-2-methylmorpholino)piperidine-1-yl)phenyl)acrylamide;

596) N-(5-((6-((R)-3-(3-chloro-5-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-((R)-2-methylmorpholino)piperidine-1-yl)phenyl)acrylamide;

597) N-(5-((6-((R)-3-(3-chloro-5-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(oxetane-3-yl)piperazine-1-yl)phenyl)acrylamide;

598) N-(5-((6-((R)-3-(2-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-morpholinopiperidine-1-yl)phenyl)acrylamide;

599) N-(5-((6-((R)-3-(3-chloro-2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((R)-3-(dimethylamino)pyrolidine-1-yl)-4-methoxyphenyl)acrylamide;

600) N-(5-((6-((R)-3-(3-chloro-2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-ethylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

601) N-(2-(4-(4-acetylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(2-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

602) N-(5-((6-((R)-3-(2-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-ethylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

603) N-(5-((6-((R)-3-(3-chloro-2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide;

604) N-(5-((6-((R)-3-(3-chloro-2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-methylpiperazine-1-yl)phenyl)acrylamide;

605) N-(5-((6-((R)-3-(3-chloro-2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-methylpiperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

606) N-(5-((6-((R)-3-(3-chloro-2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-morpholinopiperidine-1-yl)phenyl)acrylamide;

607) N-(5-((6-((R)-3-(2,3-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((1S,4S)-5-ethyl-2,5-diazabicyclo[2.2.1]heptane-2-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

608) N-(2-(4-(4-acetylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(2,3-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

609) N-(5-((6-((R)-3-(2,3-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-isopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

610) N-(5-((6-((R)-3-(2,3-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((R)-3-(dimethylamino)pyrolidine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

611) N-(5-((6-((R)-3-(2,3-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-(1-methylpiperidine-4-yl)piperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

612) N-(2-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)-5-((6-((R)-3-(3,4-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

613) N-(5-((6-((R)-3-(2,3-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((2-(dimethylamino)ethyl)(methyl)amino)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

614) N-(5-((6-((R)-3-(2,3-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-morpholino-[1,4′-bipiperidine]-1′-yl)phenyl)acrylamide;

615) N-(5-((6-((R)-3-(3,4-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-morpholinophenyl)acrylamide;

616) N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((6-((R)-3-(3-ethynylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

617) N-(5-((6-((R)-3-(3-ethynylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-methylpiperazine-1-yl)phenyl)acrylamide;

618) N-(2-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((R)-3-(3-ethynylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

619) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((R)-3-(3-ethynylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

620) N-(4-methoxy-2-(4-(4-methylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(2,3,4-trifluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

621) N-(4-methoxy-2-(4-morpholinopiperidine-1-yl)-5-((6-((R)-3-(2,3,4-trifluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

622) N-(2-((R)-3-(dimethylamino)pyrolidine-1-yl)-4-methoxy-5-((6-((R)-3-(2,3,4-trifluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

623) N-(4-methoxy-2-((R)-3-morpholinopyrolidine-1-yl)-5-((6-((R)-3-(2,3,4-trifluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

624) N-(4-methoxy-2-((S)-3-morpholinopyrolidine-1-yl)-5-((6-((R)-3-(2,3,4-trifluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

625) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((S)-3-((dimethylamino)methyl)pyrolidine-1-yl)-4-methoxyphenyl)acrylamide;

626) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((S)-3-((dimethylamino)methyl)pyrolidine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

627) N-(5-((6-((R)-3-(3-chloro-5-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(dimethylamino)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

628) N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((6-((R)-3-(2,3,6-trifluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

629) N-(4-methoxy-2-(4-methylpiperazine-1-yl)-5-((6-((R)-3-(2,3,6-trifluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

630) N-(2-((R)-3-(dimethylamino)pyrolidine-1-yl)-4-methoxy-5-((6-((R)-3-(2,3,6-trifluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

631) N-(2-(4-ethylpiperazine-1-yl)-4-methoxy-5-((6-((R)-3-(2,3,6-trifluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

632) N-(4-methoxy-2-(4-morpholinopiperidine-1-yl)-5-((6-((R)-3-(2,3,6-trifluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

633) N-(3-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-5-(4-methylpiperazine-1-yl)phenyl)acrylamide;

634) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((R)-3-(2-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

635) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((R)-3-(3-chloro-2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

636) N-(2-(4-(4-acetylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3-chloro-2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

637) N-(2-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((R)-3-(3-chloro-2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

638) N-(5-((6-((R)-3-(3-chloro-2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(dimethylamino)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

639) N-(5-((6-((R)-3-(3-chloro-2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-ethylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

640) N-(2-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((R)-3-(2-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

641) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(2,3,6-trifluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

642) N-(2-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(2,3,6-trifluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

643) N-(2-(4-(4-isopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(2,3,6-trifluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

644) N-(2-(4-((2S,6R)-2,6-dimethylmorpholino)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(2,3,6-trifluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

645) N-(4-methoxy-2-(4-((S)-2-methylmorpholino)piperidine-1-yl)-5-((6-((R)-3-(2,3,6-trifluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

646) N-(4-methoxy-2-(4-((R)-2-methylmorpholino)piperidine-1-yl)-5-((6-((R)-3-(2,3,6-trifluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

647) N-(2-(4-(dimethylamino)piperidine-1-yl)-5-((6-((R)-3-(3-ethynylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

648) N-(2-(4-ethylpiperazine-1-yl)-5-((6-((R)-3-(3-ethynylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

649) N-(5-((6-((R)-3-(3-ethynylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-methylpiperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

650) N-(5-((6-((R)-3-(3-ethynylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-morpholinopiperidine-1-yl)phenyl)acrylamide;

651) N-(2-(4-((2S,6R)-2,6-dimethylmorpholino)piperidine-1-yl)-5-((6-((R)-3-(3-ethynylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

652) N-(2-(4-(4-ethylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3-ethynylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

653) N-(2-((R)-3-(dimethylamino)pyrolidine-1-yl)-5-((6-((R)-3-(3-ethynylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

654) N-(2-(4-cyclopropylpiperazine-1-yl)-5-((6-((R)-3-(3-ethynylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

655) N-(2-(4-(dimethylamino)-[1,4′-bipiperidine]-1′-yl)-5-((6-((R)-3-(3-ethynylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

656) N-(2-(4-(dimethylamino)-[1,4′-bipiperidine]-1′-yl)-4-methoxy-5-((6-((R)-3-(2,3,4-trifluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

657) N-(5-((6-((R)-3-(3-chloro-2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((S)-2-methylmorpholino)phenyl)acrylamide;

658) N-(5-((6-((R)-3-(3-chloro-2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((2S,6S)-2,6-dimethylmorpholino)-4-methoxyphenyl)acrylamide;

659) N-(4-methoxy-2-((S)-2-methylmorpholino)-5-((6-((R)-3-(naphthalene-2-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

660) N-(2-((2S,6S)-2,6-dimethylmorpholino)-4-methoxy-5-((6-((R)-3-(naphthalene-2-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

661) N-(5-((6-((R)-3-(2-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-isopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

662) N-(2-((S)-3,4-dimethylpiperazine-1-yl)-4-methoxy-5-((6-((R)-3-(naphthalene-2-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

663) N-(4-methoxy-2-((R)-2-methylmorpholino)-5-((6-((R)-3-(naphthalene-2-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

664) N-(2-((2S,6R)-2,6-dimethylmorpholino)-4-methoxy-5-((6-((R)-3-(naphthalene-2-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

665) N-(5-((6-((R)-3-(3-chloro-2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((S)-3,4-dimethylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

666) N-(5-((6-((R)-3-(3-chloro-2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((R)-2-methylmorpholino)phenyl)acrylamide;

667) N-(5-((6-((R)-3-(3-chloro-2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((2S,6R)-2,6-dimethylmorpholino)-4-methoxyphenyl)acrylamide;

668) N-(5-((6-((R)-3-(3-chloro-2,4-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-isopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

669) N-(5-((6-((R)-3-(3,4-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide;

670) N-(5-((6-((R)-3-(3,4-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-methylpiperazine-1-yl)phenyl)acrylamide;

671) N-(2-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)-5-((6-((R)-3-(3,4-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

672) N-(5-((6-((R)-3-(3,4-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-ethylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

673) N-(2-(4-cyclopropylpiperazine-1-yl)-5-((6-((R)-3-(3,4-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

674) N-(5-((6-((R)-3-(3,4-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((1R,4R)-5-methyl-2,5-diazabicyclo[2.2.1]heptane-2-yl)phenyl)acrylamide;

675) N-(2-(4-acetylpiperazine-1-yl)-5-((6-((R)-3-(3,4-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

676) N-(5-((6-((R)-3-(3,4-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((1R,4R)-5-ethyl-2,5-diazabicyclo[2.2.1]heptane-2-yl)-4-methoxyphenyl)acrylamide;

677) N-(5-((6-((R)-3-(3,4-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(dimethylamino)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

678) N-(5-((6-((R)-3-(3,4-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((1S,4S)-5-ethyl-2,5-diazabicyclo[2.2.1]heptane-2-yl)-4-methoxyphenyl)acrylamide;

679) N-(5-((6-((R)-3-(3,4-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((2-methoxyethyl)(methyl)amino)phenyl)acrylamide;

680) N-(5-((6-((R)-3-(3,4-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-isopropylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

681) N-(5-((6-((R)-3-(3,4-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-methylpiperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

682) N-(5-((6-((R)-3-(3,4-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((R)-3-(dimethylamino)pyrolidine-1-yl)-4-methoxyphenyl)acrylamide;

683) N-(5-((6-((R)-3-(3,4-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-morpholinopiperidine-1-yl)phenyl)acrylamide;

684) N-(5-((6-((R)-3-(3,4-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptane-2-yl)phenyl)acrylamide;

685) N-(5-((6-((R)-3-(3,4-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(1-methylpiperidine-4-yl)piperazine-1-yl)phenyl)acrylamide;

686) N-(5-((6-((R)-3-(3,4-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(2-(dimethylamino)ethyl)piperazine-1-yl)-4-methoxyphenyl)acrylamide;

687) N-(2-(4-(cyclopropylmethyl)piperazine-1-yl)-5-((6-((R)-3-(3,4-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

688) N-(2-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((R)-3-(3,4-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

689) N-(5-((6-((R)-3-(3,4-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-isopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

690) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((R)-3-(3,4-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

691) N-(5-((6-((R)-3-(2-chloro-3,6-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-cyclopropylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

692) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((R)-3-(2-chloro-3,6-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

693) N-(2-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((R)-3-(2-chloro-3,6-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

694) N-(5-((6-((R)-3-(4-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-methylpiperazine-1-yl)phenyl)acrylamide;

695) N-(5-((6-((R)-3-(4-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((R)-3-(dimethylamino)pyrolidine-1-yl)-4-methoxyphenyl)acrylamide;

696) N-(5-((6-((R)-3-(3,4-dichloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-methylpiperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

697) N-(5-((6-((R)-3-(3,4-dichloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-morpholinopiperidine-1-yl)phenyl)acrylamide;

698) N-(2-(4-ethylpiperazine-1-yl)-4-methoxy-5-((6-((R)-3-(3-methoxyphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

699) N-(2-(4-(4-ethylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(3-methoxyphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

700) N-(2-(4-(6-azaspiro[2.5]octan-6-yl)piperidine-1-yl)-5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

701) N-(5-((6-((R)-3-(3-chloro-4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide;

702) N-(5-((6-((R)-3-(3-chloro-4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-methylpiperazine-1-yl)phenyl)acrylamide;

703) N-(5-((6-((R)-3-(3-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((S)-3-(dimethylamino)pyrolidine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

704) N-(2-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((R)-3-(3-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

705) N-(2-(4-(4-acetylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

706) N-(5-((6-((R)-3-(3-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((2S,6R)-2,6-dimethylmorpholino)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

707) N-(5-((6-((R)-3-(3-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-isopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

708) N-(5-((6-((R)-3-(4-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-isopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

709) N-(5-((6-((R)-3-(4-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((2S,6R)-2,6-dimethylmorpholino)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

710) N-(2-(4-((2S,6R)-2,6-dimethylmorpholino)piperidine-1-yl)-5-((6-((R)-3-(3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

711) N-(5-((6-((R)-3-(3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-isopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

712) N-(5-((6-((R)-3-(3-chloro-4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((2S,6R)-2,6-dimethylmorpholino)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

713) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(3-(dimethylamino)azetidine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

714) N-(5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((2S,6R)-2,6-dimethylmorpholino)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

715) N-(5-((6-((R)-3-(3-chloro-4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-isopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

716) N-(2-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((R)-3-(3-chloro-4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

717) N-(2-(4-(4-cyclopropyl-1,4-diazepane-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

718) N-(2-(4,4-difluoro-[1,4′-bipiperidine]-1′-yl)-5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

719) N-(5-((6-((R)-3-(3-chloro-4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-methylpiperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

720) N-(5-((6-((R)-3-(3-chloro-4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-morpholinopiperidine-1-yl)phenyl)acrylamide;

721) N-(5-((6-((R)-3-(3-chloro-4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-ethylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

722) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-methyl-2-oxopiperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

723) N-(5-((6-((R)-3-(3-chloro-4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-ethylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

724) N-(5-((6-((R)-3-(3-chloro-4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-isopropylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

725) N-(5-((6-((R)-3-(3-chloro-4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-cyclopropylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

726) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(3-methoxyphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

727) N-(2-(4-((2S,6R)-2,6-dimethylmorpholino)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(3-methoxyphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

728) N-(2-(4-((R)-3-(dimethylamino)pyrolidine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(3-methoxyphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

729) N-(2-(4-((S)-3-(dimethylamino)pyrolidine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(3-methoxyphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

730) N-(4-methoxy-5-((6-((R)-3-(3-methoxyphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(oxetane-3-yl)piperazine-1-yl)phenyl)acrylamide;

731) N-(2-(4-(dimethylamino)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(3-methoxyphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

732) N-(5-((6-((R)-3-(4-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-methylpiperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

733) N-(5-((6-((R)-3-(4-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((R)-3-morpholinopyrolidine-1-yl)phenyl)acrylamide;

734) N-(5-((6-((R)-3-(4-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((S)-3-morpholinopyrolidine-1-yl)phenyl)acrylamide;

735) N-(2-(4-((2-(dimethylamino)ethyl)(methyl)amino)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

736) N-(4-methoxy-2-(4-((2-methoxyethyl)(methyl)amino)piperidine-1-yl)-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

737) N-(2-(4-((1S,4S)-5-ethyl-2,5-diazabicyclo[2.2.1]heptane-2-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

738) N-(2-(4-((1R,4R)-5-ethyl-2,5-diazabicyclo[2.2.1]heptane-2-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

739) N-(2-(4-(4-(2-(dimethylamino)ethyl)piperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

740) N-(2-(4-(dimethylamino)-[1,4′-bipiperidine]-1′-yl)-4-methoxy-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

741) N-(2-(4-(4-acetylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

742) N-(5-((6-((R)-3-(3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-methylpiperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

743) N-(5-((6-((R)-3-(3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-morpholinopiperidine-1-yl)phenyl)acrylamide;

744) N-(2-(4-((S)-3-(dimethylamino)pyrolidine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

745) N-(5-((6-((R)-3-(3-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(oxetane-3-yl)piperazine-1-yl)phenyl)acrylamide;

746) N-(5-((6-((R)-3-(3-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide;

747) N-(5-((6-((R)-3-(3-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-methylpiperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

748) N-(2-(4-((R)-3-(dimethylamino)pyrolidine-1-yl)piperidine-1-yl)-5-((6-(3-(3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

749) N-(2-(4-(dimethylamino)-[1,4′-bipiperidine]-1′-yl)-5-((6-((R)-3-(3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

750) N-(5-((6-((R)-3-(4-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-morpholinopiperidine-1-yl)phenyl)acrylamide;

751) N-(5-((6-((R)-3-(4-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-methylpiperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

752) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((2S,6S)-2,6-dimethylmorpholino)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

753) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-(2-(dimethylamino)ethyl)piperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

754) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(piperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

755) N-(5-((6-((R)-3-(3-chloro-4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(dimethylamino)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

756) N-(5-((6-((R)-3-(3-chloro-4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((R)-3-(dimethylamino)pyrolidine-1-yl)-4-methoxyphenyl)acrylamide;

757) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-((S)-2-methylmorpholino)piperidine-1-yl)phenyl)acrylamide;

758) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-((R)-2-methylmorpholino)piperidine-1-yl)phenyl)acrylamide;

759) N-(2-(4-((1R,5S)-8-oxa-3-azabicyclo[3.2.1]octan-3-yl)piperidine-1-yl)-5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

760) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((S)-3,4-dimethylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

761) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((R)-2,4-dimethylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

762) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((S)-2,4-dimethylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

763) N-(2-(4-(4-acetylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3-chloro-4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

764) N-(5-((6-((R)-3-(3-chloro-4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((S)-3-(dimethylamino)pyrolidine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

765) N-(5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-methylpiperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

766) N-(5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-morpholinopiperidine-1-yl)phenyl)acrylamide;

767) N-(5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-ethylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

768) N-(5-((6-((R)-3-(3-chloro-4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(dimethylamino)-[1,4′-bipiperidine]-1′-yl)-4-methoxyphenyl)acrylamide;

769) N-(5-((6-((R)-3-(3-chloro-4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((R)-3-(dimethylamino)pyrolidine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

770) N-(2-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((R)-3-(3,4-dichloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

771) N-(5-((6-((R)-3-(3,4-dichloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((R)-3-(dimethylamino)pyrolidine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

772) N-(5-((6-((R)-3-(3,4-dichloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((S)-3-(dimethylamino)pyrolidine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

773) N-(5-((6-((R)-3-(3,4-dichloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((2S,6R)-2,6-dimethylmorpholino)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

774) N-(2-(4-(4-acetylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3,4-dichloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

775) N-(4-methoxy-5-((6-((R)-3-(3-methoxyphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-morpholinopiperidine-1-yl)phenyl)acrylamide;

776) N-(2-((R)-3-(dimethylamino)pyrolidine-1-yl)-4-methoxy-5-((6-((R)-3-(3-methoxyphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

777) N-(4-methoxy-5-((6-((R)-3-(3-methoxyphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((R)-3-morpholinopyrolidine-1-yl)phenyl)acrylamide;

778) N-(4-methoxy-5-((6-((R)-3-(3-methoxyphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((S)-3-morpholinopyrolidine-1-yl)phenyl)acrylamide;

779) N-(2-(4-(4-acetylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(3-methoxyphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

780) N-(2-(4-(4-isopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(3-methoxyphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

781) N-(2-(4-(dimethylamino)-[1,4′-bipiperidine]-1′-yl)-4-methoxy-5-((6-((R)-3-(3-methoxyphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

782) N-(5-((6-((R)-3-(4-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-morpholinopiperidine-1-yl)phenyl)acrylamide;

783) N-(5-((6-((R)-3-(4-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((R)-3-(dimethylamino)pyrolidine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

784) N-(5-((6-((R)-3-(4-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((S)-3-(dimethylamino)pyrolidine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

785) N-(5-((6-((R)-3-(4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-methylpiperazine-1-yl)phenyl)acrylamide;

786) N-(5-((6-((R)-3-(4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-morpholinopiperidine-1-yl)phenyl)acrylamide;

787) N-(2-(4-((R)-3-(dimethylamino)pyrolidine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-phenylisoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

788) N-(5-((6-((R)-3-(3-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-morpholinopiperidine-1-yl)phenyl)acrylamide;

789) N-(5-((6-((R)-3-(3-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-methylpiperazine-1-yl)phenyl)acrylamide;

790) N-(5-((6-((R)-3-(3-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(dimethylamino)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

791) N-(5-((6-((R)-3-(3-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-ethylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

792) N-(5-((6-((R)-3-(3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(oxetane-3-yl)piperazine-1-yl)phenyl)acrylamide;

793) N-(5-((6-((R)-3-(4-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide;

794) N-(5-((6-((R)-3-(4-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((R)-3-(dimethylamino)pyrolidine-1-yl)-4-methoxyphenyl)acrylamide;

795) N-(5-((6-((R)-3-(4-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-methylpiperazine-1-yl)phenyl)acrylamide;

796) N-(2-(4-(4-acetylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(4-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

797) N-(5-((6-((R)-3-(4-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(dimethylamino)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

798) N-(5-((6-((R)-3-(4-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-ethylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

799) N-(5-((6-((R)-3-(4-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((S)-3-(dimethylamino)pyrolidine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

800) N-(5-((6-((R)-3-(4-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((R)-3-(dimethylamino)pyrolidine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

801) N-(5-((6-((R)-3-(4-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(oxetane-3-yl)piperazine-1-yl)phenyl)acrylamide;

802) N-(2-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((R)-3-(4-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

803) N-(5-((6-((R)-3-(4-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(dimethylamino)-[1,4′-bipiperidine]-1′-yl)-4-methoxyphenyl)acrylamide;

804) N-(5-((6-((R)-3-(3,4-dichloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-isopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

805) N-(5-((6-((R)-3-(4-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(dimethylamino)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

806) N-(2-(4-(4-acetylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(4-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

807) N-(5-((6-((R)-3-(4-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-isopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

808) N-(5-((6-((R)-3-(4-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(dimethylamino)-[1,4′-bipiperidine]-1′-yl)-4-methoxyphenyl)acrylamide;

809) N-(2-(4-(4-acetylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

810) N-(2-(4-((R)-3-(dimethylamino)pyrolidine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

811) N-(2-(4-((S)-3-(dimethylamino)pyrolidine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

812) N-(2-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((R)-3-(4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

813) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((R)-3-(4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

814) N-(2-(4-((2S,6R)-2,6-dimethylmorpholino)piperidine-1-yl)-5-((6-((R)-3-(4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

815) N-(2-(4-(4-acetylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

816) N-(5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((S)-3-(dimethylamino)pyrolidine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

817) N-(2-(4,4-difluoro-[1,4′-bipiperidine]-1′-yl)-5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

818) N-(5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-methylpiperazine-1-yl)phenyl)acrylamide;

819) N-(5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(dimethylamino)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

820) N-(2-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)piperidine-1-yl)-5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

821) N-(5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-((S)-2-methylmorpholino)piperidine-1-yl)phenyl)acrylamide;

822) N-(5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-((R)-2-methylmorpholino)piperidine-1-yl)phenyl)acrylamide;

823) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-morpholinophenyl)acrylamide;

824) N-(5-((6-((R)-3-(3-chloro-4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-morpholinophenyl)acrylamide;

825) N-(5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-morpholinophenyl)acrylamide;

826) N-(2-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

827) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((3S,5R)-4-ethyl-3,5-dimethylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

828) N-(2-(4-(6-azaspiro[2.5]octan-6-yl)piperidine-1-yl)-5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

829) N-(2-(4-(4-cyclopropyl-1,4-diazepane-1-yl)piperidine-1-yl)-5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

830) N-(2-(4-cyclopropylpiperazine-1-yl)-5-((6-((R)-3-(3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

831) N-(2-(4-acetylpiperazine-1-yl)-5-((6-((R)-3-(3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

832) N-(2-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)-5-((6-((R)-3-(3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

833) N-(2-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)-5-((6-((R)-3-(3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

834) N-(5-((6-((R)-3-(3-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((R)-3-(dimethylamino)pyrolidine-1-yl)-4-methoxyphenyl)acrylamide;

835) N-(2-(4-((1S,4S)-5-ethyl-2,5-diazabicyclo[2.2.1]heptane-2-yl)piperidine-1-yl)-5-((6-((R)-3-(3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

836) N-(5-((6-((R)-3-(4-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((S)-3-(dimethylamino)pyrolidine-1-yl)-4-methoxyphenyl)acrylamide;

837) N-(5-((6-((R)-3-(3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptane-2-yl)piperidine-1-yl)phenyl)acrylamide;

838) N-(5-((6-((R)-3-(3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((2-methoxyethyl)(methyl)amino)phenyl)acrylamide;

839) N-(2-((S)-3-(dimethylamino)pyrolidine-1-yl)-5-((6-((R)-3-(3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

840) N-(5-((6-((R)-3-(3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-morpholinophenyl)acrylamide;

841) N-(5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((3S,5R)-4-ethyl-3,5-dimethylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

842) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-((R)-3-methylmorpholino)piperidine-1-yl)phenyl)acrylamide;

843) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-((S)-3-methylmorpholino)piperidine-1-yl)phenyl)acrylamide;

844) N-(5-((6-((R)-3-(2-fluoro-3-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-morpholinophenyl)acrylamide;

845) N-(5-((6-((R)-3-(2-fluoro-3-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-methylpiperazine-1-yl)phenyl)acrylamide;

846) N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((6-((R)-3-(2-fluoro-3-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

847) N-(2-(4-ethylpiperazine-1-yl)-5-((6-((R)-3-(2-fluoro-3-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

848) N-(5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((R)-3-(dimethylamino)pyrolidine-1-yl)-4-methoxyphenyl)acrylamide;

849) N-(5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-ethylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

850) N-(5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((S)-3,4-dimethylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

851) N-(5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((R)-3,4-dimethylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

852) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(hexahydropyrrolo[1,2-a]pyrazine-2(1H)-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

853) N-(5-((6-((R)-3-(4-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((2-methoxyethyl)(methyl)amino)phenyl)acrylamide;

854) N-(5-((6-((R)-3-(4-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-morpholinophenyl)acrylamide;

855) N-(5-((6-((R)-3-(2-fluoro-3-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-methylpiperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

856) N-(5-((6-((R)-3-(2-fluoro-3-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-morpholinopiperidine-1-yl)phenyl)acrylamide;

857) N-(5-((6-((R)-3-(4-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptane-2-yl)piperidine-1-yl)phenyl)acrylamide;

858) N-(5-((6-((R)-3-(4-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((1S,4S)-5-ethyl-2,5-diazabicyclo[2.2.1]heptane-2-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

859) N-(5-((6-((R)-3-(4-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((1R,4R)-5-ethyl-2,5-diazabicyclo[2.2.1]heptane-2-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

860) N-(2-((R)-3-(dimethylamino)pyrolidine-1-yl)-5-((6-((R)-3-(2-fluoro-3-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

861) N-(5-((6-((R)-3-(3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(2-methyl-1H-imidazole-1-yl)phenyl)acrylamide;

862) N-(2-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)-5-((6-((R)-3-(4-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

863) N-(2-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)-5-((6-((R)-3-(4-chloro-3-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

864) N-(2-(4-(dimethylamino)piperidine-1-yl)-5-((6-((R)-3-(2-fluoro-3-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

865) N-(5-((6-((R)-3-(3,4-dichloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(dimethylamino)-[1,4′-bipiperidine]-1′-yl)-4-methoxyphenyl)acrylamide;

866) N-(2-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((R)-3-(4-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

867) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((R)-3-(4-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

868) N-(5-((6-((R)-3-(4-chlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((2S,6R)-2,6-dimethylmorpholino)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

869) N-(5-((6-((R)-3-(4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(dimethylamino)-[1,4′-bipiperidine]-1′-yl)-4-methoxyphenyl)acrylamide;

870) N-(2-(4-(dimethylamino)-[1,4′-bipiperidine]-1′-yl)-5-((6-((R)-3-(4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

871) N-(2-(4-((1R,5S)-8-oxa-3-azabicyclo[3.2.1]octan-3-yl)piperidine-1-yl)-5-((6-((R)-3-(3-chloro-4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

872) N-(2-(4-(6-azaspiro[2.5]octan-6-yl)piperidine-1-yl)-5-((6-((R)-3-(3-chloro-4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

873) N-(5-((6-((R)-3-(3-chloro-4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-((S)-2-methylmorpholino)piperidine-1-yl)phenyl)acrylamide;

874) N-(5-((6-((R)-3-(3-chloro-4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-((R)-2-methylmorpholino)piperidine-1-yl)phenyl)acrylamide;

875) N-(5-((6-((R)-3-(2,3-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((3aR,6aR)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-yl)phenyl)acrylamide;

876) N-(5-((6-((R)-3-(2,3-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((3aS,6aS)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-yl)phenyl)acrylamide;

877) N-(5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(5-methyl-2,5-diazabicyclo[2.2.1]heptane-2-yl)piperidine-1-yl)phenyl)acrylamide;

878) N-(5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((3S,5R)-4-ethyl-3,5-dimethylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

879) N-(2-((S)-4-cyclopropyl-2-methylpiperazine-1-yl)-5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

880) N-(2-((R)-4-cyclopropyl-2-methylpiperazine-1-yl)-5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

881) N-(5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(oxetane-3-yl)piperazine-1-yl)phenyl)acrylamide;

882) N-(5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide;

883) N-(5-((6-((R)-3-(2,3-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((S)-3,4-dimethylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

884) N-(5-((6-((R)-3-(2,3-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((R)-3,4-dimethylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

885) N-(5-((6-((R)-3-(2,3-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((R)-2,4-dimethylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

886) N-(5-((6-((R)-3-(2,3-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((S)-2,4-dimethylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

887) N-(2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5-((6-((R)-3-(2,3-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

888) N-(5-((6-((R)-3-(2,3-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((S)-2-methylmorpholino)phenyl)acrylamide;

889) N-(5-((6-((R)-3-(2,3-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((R)-2-methylmorpholino)phenyl)acrylamide;

890) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((3aR,6aR)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-yl)phenyl)acrylamide;

891) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((3aS,6aS)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-yl)phenyl)acrylamide;

892) N-(5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((3aR,6aR)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-yl)phenyl)acrylamide;

893) N-(5-((6-((R)-3-(2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((3aS,6aS)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-yl)phenyl)acrylamide;

894) N-(2-(4-(4-(sec-butyl)piperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

895) N-(5-((6-((S)-3-(2,6-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-ethylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

896) N-(5-((6-((S)-3-(2,6-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-methylpiperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

897) N-(5-((6-((S)-3-(2,6-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-morpholinopiperidine-1-yl)phenyl)acrylamide;

898) N-(5-((6-((S)-3-(2,6-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((3aR,6aR)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-yl)phenyl)acrylamide;

899) N-(5-((6-((S)-3-(2,6-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((3aS,6aS)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-yl)phenyl)acrylamide;

900) N-(5-((6-((R)-3-(3-chloro-4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((S)-3,4-dimethylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

901) N-(5-((6-((R)-3-(3-chloro-4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((R)-3,4-dimethylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

902) N-(2-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)-5-((6-((R)-3-(3-chloro-4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

903) N-(2-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)-5-((6-((R)-3-(3-chloro-4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

904) N-(5-((6-((R)-3-(3-chloro-4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((2-methoxyethyl)(methyl)amino)phenyl)acrylamide;

905) N-(5-((6-((R)-3-(3-chloro-4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-cyclopropylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

906) N-(5-((6-((R)-3-(3-chloro-4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((S)-3-(dimethylamino)pyrolidine-1-yl)-4-methoxyphenyl)acrylamide;

907) N-(2-(4-acetylpiperazine-1-yl)-5-((6-((R)-3-(3-chloro-4-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

908) N-(5-((6-((R)-3-(2-fluoro-3-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(oxetane-3-yl)piperazine-1-yl)phenyl)acrylamide;

909) N-(2-(4-cyclopropylpiperazine-1-yl)-5-((6-((R)-3-(2-fluoro-3-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

910) N-(2-(4-((S)-3-(dimethylamino)pyrolidine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(2-fluoro-3-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

911) N-(5-((6-((R)-3-(2-fluoro-3-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-isopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

912) N-(2-(4-((2S,6R)-2,6-dimethylmorpholino)piperidine-1-yl)-5-((6-((R)-3-(2-fluoro-3-methylphenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

913) N-(5-((6-((R)-3-(3-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-ethylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

914) N-(5-((6-((R)-3-(3-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((R)-3-(dimethylamino)pyrolidine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

915) N-(5-((6-((R)-3-(3-chloro-2-fluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(dimethylamino)-[1,4′-bipiperidine]-1′-yl)-4-methoxyphenyl)acrylamide;

916) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((S)-3,4-dimethylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

917) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((R)-3,4-dimethylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

918) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((R)-2,4-dimethylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

919) N-(5-((6-((R)-3-(3,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((S)-2,4-dimethylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

920) N-(5-((6-((R)-3-(2,3-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-morpholinopiperidine-1-yl)phenyl)acrylamide;

921) N-(5-((6-((R)-3-(2,3-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-methylpiperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

922) N-(5-((6-((R)-3-(2,3-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-ethylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

923) N-(5-((6-((R)-3-(2,3-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(oxetane-3-yl)piperazine-1-yl)phenyl)acrylamide;

924) N-(5-((6-((R)-3-(2,3-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide;

925) N-(5-((6-((R)-3-(2,3-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-methylpiperazine-1-yl)phenyl)acrylamide;

926) N-(5-((6-((R)-3-(2,3-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(dimethylamino)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

927) N-(5-((6-((R)-3-(2,3-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((R)-3-(dimethylamino)pyrolidine-1-yl)-4-methoxyphenyl)acrylamide;

928) N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((6-((R)-3-(thiophene-2-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

929) N-(4-methoxy-2-(4-methylpiperazine-1-yl)-5-((6-((R)-3-(thiophene-2-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

930) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(thiophene-2-yl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

931) N-(5-((6-((R)-3-(3,4-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-(oxetane-3-yl)piperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

932) N-(2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-5-((6-((R)-3-(3,4-dichlorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

933) N-(5-((6-((R)-3-(2-chloro-3,6-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

934) N-(5-((6-((R)-3-(2-chloro-3,6-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((S)-4-cyclopropyl-3-methylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

935) N-(5-((6-((R)-3-(2-chloro-3,6-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((R)-4-cyclopropyl-3-methylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

936) N-(5-((6-((S)-3-(2-chloro-3,6-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

937) N-(2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((S)-3-(2,3,6-trifluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

938) N-(5-((6-((R)-3-(3-chloro-2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

939) N-(5-((6-((R)-3-(3-chloro-2,5-difluorophenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-cyclopropylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

940) N-(2-(4-cyclopropylpiperazine-1-yl)-4-methoxy-5-((6-((R)-3-(3-(trifluoromethyl)phenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

941) N-(2-(4-((S)-4-cyclopropyl-3-methylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(3-(trifluoromethyl)phenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

942) N-(2-(4-((R)-4-cyclopropyl-3-methylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(3-(trifluoromethyl)phenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

943) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(3-(trifluoromethyl)phenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

944) N-(2-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(3-(trifluoromethyl)phenyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

945) N-(5-((6-((S)-3-benzylisoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-methylpiperazine-1-yl)phenyl)acrylamide;

946) N-(5-((6-((S)-3-benzylisoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-ethylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

947) N-(5-((6-((S)-3-benzylisoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide;

948) N-(2-(4-acetylpiperazine-1-yl)-5-((6-((S)-3-benzylisoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

949) N-(5-((6-((S)-3-benzylisoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((1R,4R)-5-ethyl-2,5-diazabicyclo[2.2.1]heptane-2-yl)-4-methoxyphenyl)acrylamide;

950) N-(5-((6-((S)-3-benzylisoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((1S,4S)-5-ethyl-2,5-diazabicyclo[2.2.1]heptane-2-yl)-4-methoxyphenyl)acrylamide;

951) N-(5-((6-((S)-3-benzylisoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(dimethylamino)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

952) N-(5-((6-((S)-3-benzylisoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-cyclopropylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

953) N-(5-((6-((S)-3-benzylisoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-((2-methoxyethyl)(methyl)amino)phenyl)acrylamide;

954) N-(5-((6-((S)-3-benzylisoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-isopropylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

955) N-(5-((6-((S)-3-benzylisoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

956) N-(5-((6-((R)-3-benzylisoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

957) N-(5-((6-((S)-3-benzylisoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)-4-methoxyphenyl)acrylamide;

958) N-(5-((6-((S)-3-benzylisoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(oxetane-3-yl)piperazine-1-yl)phenyl)acrylamide;

959) N-(5-((6-((S)-3-benzylisoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(cyclopropylmethyl)piperazine-1-yl)-4-methoxyphenyl)acrylamide;

960) N-(5-((6-((S)-3-benzylisoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(2-methyl-1H-imidazole-1-yl)phenyl)acrylamide;

961) N-(5-((6-((S)-3-benzylisoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(2-(dimethylamino)ethyl)piperazine-1-yl)-4-methoxyphenyl)acrylamide;

962) N-(5-((6-((S)-3-benzylisoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)-4-methoxyphenyl)acrylamide;

963) N-(5-((6-((S)-3-benzylisoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(4-methylpiperazine-1-yl)piperidine-1-yl)phenyl)acrylamide;

964) N-(5-((6-((S)-3-benzylisoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((R)-3-(dimethylamino)pyrolidine-1-yl)-4-methoxyphenyl)acrylamide;

965) N-(5-((6-((S)-3-benzylisoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-morpholinopiperidine-1-yl)phenyl)acrylamide;

966) N-(5-((6-((R)-3-benzylisoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-morpholinophenyl)acrylamide;

967) N-(5-((6-((R)-3-benzylisoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(cyclopropylmethyl)piperazine-1-yl)-4-methoxyphenyl)acrylamide;

968) N-(5-((6-((R)-3-benzylisoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-methylpiperazine-1-yl)phenyl)acrylamide;

969) N-(5-((6-((S)-3-benzylisoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(5-methyl-2,5-diazabicyclo[2.2.1]heptane-2-yl)phenyl)acrylamide;

970) N-(5-((6-((S)-3-benzylisoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(1-methylpiperidine-4-yl)piperazine-1-yl)phenyl)acrylamide;

971) N-(5-((6-((S)-3-benzylisoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(tetrahydro-2H-pyran-4-yl)piperazine-1-yl)phenyl)acrylamide;

972) N-(5-((6-((S)-3-benzylisoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-cyclopentylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

973) N-(5-((6-((R)-3-benzylisoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide;

974) N-(5-((6-((R)-3-benzylisoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(1-methylpiperidine-4-yl)piperazine-1-yl)phenyl)acrylamide;

975) N-(5-((6-((R)-3-benzylisoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-(tetrahydro-2H-pyran-4-yl)piperazine-1-yl)phenyl)acrylamide;

976) N-(5-((6-((R)-3-benzylisoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(2-(dimethylamino)ethyl)piperazine-1-yl)-4-methoxyphenyl)acrylamide;

977) N-(5-((6-((R)-3-benzylisoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-cyclopentylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

978) N-(5-((6-((S)-3-benzylisoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(2-(diethylamino)ethoxy)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

979) N-(5-((6-((S)-3-(2,3-dichlorobenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-morpholinopiperidine-1-yl)phenyl)acrylamide;

980) N-(2-(4-((R)-4-cyclopropyl-3-methylpiperazine-1-yl)piperidine-1-yl)-5-((6-((S)-3-(2,3-dichlorobenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

981) N-(2-(4-((S)-4-cyclopropyl-3-methylpiperazine-1-yl)piperidine-1-yl)-5-((6-((S)-3-(2,3-dichlorobenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

982) N-(5-((6-((S)-3-(2,3-dichlorobenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide;

983) N-(5-((6-((S)-3-(2,3-dichlorobenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-methylpiperazine-1-yl)phenyl)acrylamide;

984) N-(5-((6-((S)-3-(2,3-dichlorobenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((R)-3-(dimethylamino)pyrolidine-1-yl)-4-methoxyphenyl)acrylamide;

985) N-(2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((S)-3-(pyridine-3-ylmethyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

986) N-(2-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-4-methoxy-5-((6-((S)-3-(pyridine-3-ylmethyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

987) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-4-methoxy-5-((6-((S)-3-(pyridine-3-ylmethyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

988) N-(2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(pyridine-3-ylmethyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

989) N-(2-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(pyridine-3-ylmethyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

990) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(pyridine-3-ylmethyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

991) N-(5-((6-((S)-3-(3-fluorobenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-methylpiperazine-1-yl)phenyl)acrylamide;

992) N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((6-((S)-3-(3-fluorobenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

993) N-(2-(4-((S)-4-cyclopropyl-3-methylpiperazine-1-yl)piperidine-1-yl)-5-((6-((S)-3-(3-fluorobenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

994) N-(2-(4-((R)-4-cyclopropyl-3-methylpiperazine-1-yl)piperidine-1-yl)-5-((6-((S)-3-(3-fluorobenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

995) N-(2-(4-((1R,5S)-8-cyclopropyl-3,8-diazabicyclo[3.2.1]octan-3-yl)piperidine-1-yl)-5-((6-((S)-3-(3-fluorobenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

996) N-(5-((6-((S)-3-(3-fluorobenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-morpholinopiperidine-1-yl)phenyl)acrylamide;

997) N-(2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-5-((6-((S)-3-(3-fluorobenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

998) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((S)-3-(3-fluorobenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

999) N-(2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-5-((6-((S)-3-(3-fluoro-2-methylbenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

1000) N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((6-((S)-3-(3-fluoro-2-methylbenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

1001) N-(5-((6-((S)-3-(3-fluoro-2-methylbenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-methylpiperazine-1-yl)phenyl)acrylamide;

1002) N-(2-((R)-3-(dimethylamino)pyrolidine-1-yl)-5-((6-((S)-3-(3-fluoro-2-methylbenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

1003) N-(2-(4-ethylpiperazine-1-yl)-5-((6-(S)-(3-(3-fluoro-2-methylbenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

1004) N-(2-(4-((R)-4-cyclopropyl-3-methylpiperazine-1-yl)piperidine-1-yl)-5-((6-((S)-3-(3-fluoro-2-methylbenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

1005) N-(2-(4-((S)-4-cyclopropyl-3-methylpiperazine-1-yl)piperidine-1-yl)-5-((6-((S)-3-(3-fluoro-2-methylbenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

1006) N-(5-((6-((S)-3-(2-chloro-3-fluorobenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-cyclopropylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

1007) N-(5-((6-((S)-3-(2-chloro-3-fluorobenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

1008) N-(5-((6-((S)-3-(2,3-dichlorobenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-ethylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

1009) N-(2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-5-((6-((S)-3-(2,3-dichlorobenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

1010) N-(5-((6-((S)-3-(2,3-dichlorobenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((2S,6R)-2,6-dimethylmorpholino)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

1011) N-(5-((6-((S)-3-(2,3-dichlorobenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-((R)-2-methylmorpholino)piperidine-1-yl)phenyl)acrylamide;

1012) N-(2-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((S)-3-(2,3-dichlorobenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

1013) N-(5-((6-((S)-3-(2,3-dichlorobenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxy-2-(4-((S)-2-methylmorpholino)piperidine-1-yl)phenyl)acrylamide;

1014) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((S)-3-(2,3-dichlorobenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

1015) N-(5-((6-((S)-3-(2,3-dichlorobenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-isopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

1016) N-(5-((6-((S)-3-(3-chloro-2-fluorobenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide;

1017) N-(5-((6-((S)-3-(3-chloro-2-fluorobenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-cyclopropylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

1018) N-(5-((6-((S)-3-(3-chloro-2-fluorobenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((S)-4-cyclopropyl-3-methylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

1019) N-(5-((6-((S)-3-(3-chloro-2-fluorobenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((R)-4-cyclopropyl-3-methylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

1020) N-(5-((6-((S)-3-(3-chloro-2-fluorobenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

1021) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((S)-3-(3-chloro-2-fluorobenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

1022) N-(2-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((S)-3-(3-chloro-2-fluorobenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

1023) N-(2-(4-(4-cyclobutylpiperazine-1-yl)piperidine-1-yl)-5-((6-((S)-3-(2,3-dichlorobenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

1024) N-(2-(4-(4-allylpiperazine-1-yl)piperidine-1-yl)-5-((6-((S)-3-(2,3-dichlorobenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

1025) N-(5-((6-((S)-3-(3-chloro-2-methylbenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

1026) N-(5-((6-((S)-3-(3-chloro-2-methylbenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-cyclopropylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

1027) N-(5-((6-((S)-3-(3-chloro-2-methylbenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((R)-4-cyclopropyl-3-methylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

1028) N-(5-((6-((S)-3-(3-chloro-2-methylbenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((S)-4-cyclopropyl-3-methylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

1029) N-(2-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((S)-3-(3-chloro-2-methylbenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

1030) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((S)-3-(3-chloro-2-methylbenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

1031) N-(5-((6-((S)-3-(3,5-difluorobenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide;

1032) N-(2-(4-cyclopropylpiperazine-1-yl)-5-((6-(S)-(3-(3,5-difluorobenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

1033) N-(2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-5-((6-((S)-3-(3,5-difluorobenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

1034) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((S)-3-(3,5-difluorobenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

1035) N-(2-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((S)-3-(3,5-difluorobenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

1036) N-(5-((6-((S)-3-(2-chloro-3-fluorobenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((R)-4-cyclopropyl-3-methylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

1037) N-(5-((6-((S)-3-(2-chloro-3-fluorobenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-((S)-4-cyclopropyl-3-methylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

1038) N-(2-(4-cyclopropylpiperazine-1-yl)-5-((6-((S)-3-(3-fluoro-2-methylbenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

1039) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((S)-3-(3-fluoro-2-methylbenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

1040) N-(2-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((S)-3-(3-fluoro-2-methylbenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

1041) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((S)-3-(2-chloro-3-fluorobenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

1042) N-(2-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((S)-3-(2-chloro-3-fluorobenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

1043) N-(2-(4-cyclopropylpiperazine-1-yl)-5-((6-((S)-3-(3-(dimethylamino)benzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

1044) N-(2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-5-((6-((S)-3-(3-(dimethylamino)benzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

1045) N-(2-(4-((S)-4-cyclopropyl-3-methylpiperazine-1-yl)piperidine-1-yl)-5-((6-((S)-3-(3-(dimethylamino)benzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

1046) N-(2-(4-((R)-4-cyclopropyl-3-methylpiperazine-1-yl)piperidine-1-yl)-5-((6-((S)-3-(3-(dimethylamino)benzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

1047) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((S)-3-(3-(dimethylamino)benzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

1048) N-(2-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((S)-3-(3-(dimethylamino)benzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

1049) N-(2-(4-cyclopropylpiperazine-1-yl)-4-methoxy-5-((6-((S)-3-(4-(trifluoromethyl)benzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

1050) N-(2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((S)-3-(4-(trifluoromethyl)benzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

1051) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-4-methoxy-5-((6-((S)-3-(4-(trifluoromethyl)benzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

1052) N-(2-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-4-methoxy-5-((6-((S)-3-(4-(trifluoromethyl)benzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

1053) N-(5-((6-((S)-3-(3-chloro-2-methoxybenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-cyclopropylpiperazine-1-yl)-4-methoxyphenyl)acrylamide;

1054) N-(5-((6-((S)-3-(3-chloro-2-methoxybenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxyphenyl)acrylamide;

1055) N-(2-(4-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-yl)piperidine-1-yl)-5-((6-((S)-3-(3-chloro-2-methoxybenzyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)-4-methoxyphenyl)acrylamide;

1056) N-(2-(4-((R)-4-cyclopropyl-3-methylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((S)-3-(pyridine-3-ylmethyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

1057) N-(2-(4-((S)-4-cyclopropyl-3-methylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((S)-3-(pyridine-3-ylmethyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide;

1058) N-(2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((R)-3-(pyridine-2-ylmethyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide; and

1059) N-(2-(4-(4-cyclopropylpiperazine-1-yl)piperidine-1-yl)-4-methoxy-5-((6-((S)-3-(pyridine-2-ylmethyl)isoxazolidine-2-yl)pyrimidine-4-yl)amino)phenyl)acrylamide, or a stereoisomer, hydrate, or pharmaceutically acceptable salt thereof.

10. A pharmaceutical composition comprising a compound of claim 1 , or a stereoisomer, hydrate, or pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable carriers.

11. A compound selected from the group consisting of: