SIALYLATED GLYCOPROTEIN COMPOSITONS AND USES THEREOF
The present application relates to sialylated glycoprotein compositions and methods of their use in treating various conditions and disorders.
1 .- 27 . (canceled)
28 . A method for treating mucopolysaccharidosis type 7 in a subject in need thereof, comprising administering to the subject a composition comprising a recombinant β-glucuronidase, wherein the recombinant β-glucuronidase is administered every other week by continuous intravenous infusion at a dose of 1 mg/kg to 8 mg/kg.
29 . The method of claim 28 , wherein the subject is a human.
30 . The method of claim 28 , wherein the recombinant β-glucuronidase is administered at a dose of 2 mg/kg to 6 mg/kg.
31 . The method of claim 28 , wherein the recombinant β-glucuronidase is administered at a dose of 4 mg/kg.
32 . The method of claim 28 , wherein the recombinant β-glucuronidase is administered concurrently with or following antihistamine therapy.