IP Library Granted Patent US 12,105,169
Granted Patent B2
US 12,105,169 · App. 17/535,250 · Granted Oct 1, 2024

High-dimensional fast convolutional framework (HICU) for calibrationless MRI

Inventors: Shen Zhao (Columbus, OH); Rizwan Ahmad (Columbus, OH); Lee Potter (Riverlea, OH)
Assignee: Ohio State Innovation Foundation
G01R33/4818G01R33/543G01R33/5608G01R33/5611G01R33/5619
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Quick Facts
Patent No.
US 12,105,169
App. No.
17/535,250
Granted
Oct 1, 2024
Kind
B2
Abstract

The present disclosure is directed to a computational procedure for accelerated, calibrationless magnetic resonance image (CI-MRI) reconstruction that is fast, memory efficient, and scales to high dimensional imaging. The computational procedure, High-dimensional fast ConvolUtional framework (HICU), provides fast, memory-efficient recovery of unsampled k-space points.

Claims (30)

1. A method for Magnetic Resonance Imaging (MRI) reconstruction comprising:

acquiring undersampled k-space MRI data;

interpolating and extrapolating the undersampled k-space MRI data to form a completed k-space data array;

computing, by convergent iteration, the completed data array to minimize a cost function defined as the weighted distance of a multi-level block Hankel matrix to a manifold of matrices with a rank, r, that is an integer value associated with a cost function;

converting the completed data array into reconstructed images; and

displaying the reconstructed images.

2. The method in claim 1 , wherein, at each iteration, an element in the linear variety of multi-level block Hankel matrices is parsimoniously parametrized and updated using the k-space data array and the principal r right singular vectors from the previous iterate, without recourse to the full tangent space to the low-rank manifold.

3. The method in claim 2 where the cost function is augmented by one or more functionals differentiable with respect to the entries in the data array; examples include barrier function for exact match of observed k-space samples and a weighted norm of mismatch between estimated and observed k-space samples.

4. The method in claim 2 where an image or k-space denoising subroutine is called within each iteration.

5. The method in claim 2 , wherein computation of a descent direction on the variety is accelerated by reducing the dimensionality of the multi-level Hankel matrix nullspace from r to p, constructed either explicitly or implicitly for the purpose of computing a descent direction.

6. The method in claim 2 , wherein the time to convergence is accelerated by interpolating a small subregion of the data array, then progressively expanding the region to encompass the entirety of the data array.

7. The method in claim 2 , wherein k-space data array has dimensions beyond spatial frequency, including time, coil, diffusion encoding, and velocity encoding.

8. The method in claim 2 , wherein update of multi-level Hankel matrix nullspace is stopped, while continuing descent iterations to update the data array.

9. The method in claim 2 , wherein additional nullspace vectors are approximated at initialization by collapsing one dimension of the completed data array via averaging.

10. The method in claim 2 , wherein the kernel size used to construct the multi-level Hankel matrix has, in any dimension, any integer size no less than 1 and no greater than the size of the data array in the corresponding dimension.

11. The method of claim 2 , wherein the kernel size used to define the multi-level Hankel matrix is modified from iteration to iteration.

12. The method of claim 5 , wherein the dimension, p, of the reduced-dimension nullspace is modified from iteration to iteration.

13. The method of claim 2 , wherein the coil dimension of the data array is compressed to a smaller dimension or expanded using virtual coils via conjugate symmetry.

14. The method in claim 2 , wherein the procedure is applied independently and in parallel to planes of dimension N-1 extracted from the N-dimensional data array.

15. The method of claim 2 , wherein initial iterations for a data array of dimension N are accelerated by operating on (N-q)-dimensional planes of the data array for 1<q<N.

16. A non-transitory computer-readable storage medium storing instructions that when executed by a computer cause the computer to perform a method for Magnetic Resonance Imaging (MRI) reconstruction, comprising:

acquiring undersampled k-space MRI data;

interpolating and extrapolating the undersampled k-space MRI data to form a completed k-space data array;

computing, by convergent iteration, the completed data array to minimize a cost function defined as the weighted distance of a multi-level block Hankel matrix to a manifold of matrices with a rank, r, that is an integer value associated with a cost function:

converting the completed data array into reconstructed images; and

displaying the reconstructed images.

17. The non-transitory computer-readable storage medium as recited in claim 16 , further comprising instructions wherein, at each iteration, an element in the linear variety of multi-level block Hankel matrices is parsimoniously parametrized and updated using the k-space data array and the principal r right singular vectors from the previous iterate, without recourse to the full tangent space to the low-rank manifold.

18. The non-transitory computer-readable storage medium as recited in claim 17 , further comprising instructions wherein the cost function is augmented by one or more functionals differentiable with respect to the entries in the data array; examples include barrier function for exact match of observed k-space samples and a weighted norm of mismatch between estimated and observed k-space samples.

19. The non-transitory computer-readable storage medium as recited in claim 17 , further comprising instructions wherein computation of a descent direction on the variety is accelerated by reducing the dimensionality of the multi-level Hankel matrix nullspace from r to p, constructed either explicitly or implicitly for the purpose of computing a descent direction.

20. The non-transitory computer-readable storage medium as recited in claim 17 , further comprising instructions wherein the time to convergence is accelerated by interpolating a small subregion of the data array, then progressively expanding the region to encompass the entirety of the data array.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 9, 2024
From: ZHAO, SHEN; AHMAD, RIZWAN; POTTER, LEE
To: OHIO STATE INNOVATION FOUNDATION
Reel/Frame 066426/0199 →
CONFIRMATORY LICENSE Recorded Dec 13, 2023
From: OHIO STATE UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 065989/0569 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 10, 2023
From: ZHAO, SHEN; AHMAD, RIZWAN; POTTER, LEE
To: OHIO STATE INNOVATION FOUNDATION
Reel/Frame 063274/0513 →
Continuity (2)
Provisional Application 63141520 · Jan 26, 2021
Related Publication 20220244333A1 · Aug 4, 2022