Granted Patent
B2
US 11,629,161 · App. 17/537,612 · Granted Apr 18, 2023
Synthesis of 1:1:1 co-crystal of 1-cyano-2-(4-cyclopropyl-benzyl)-4-(ß-d-glucopyranos-1-yl)-benzene, L-proline and water
Inventors:
Matthias Eckhardt (Biberach an der Riss, DE); Monika Brink (Gau-Algesheim, DE); Frank Himmelsbach (Mittelbiberach, DE); Stefan Sahli (Zofingen, CH); Chutian Shu (Shanghai, CN); Xiao-Jun Wang (Ridgefield, CT); Beat Theodor Weber (Zofingen, CH); Bing-Shiou Yang (Southbury, CT)
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Abstract
Intermediate compounds are described herein and which are used to manufacture a crystalline compound 1-cyano-2-(4-cyclopropyl-benzyl)-4-(β-D-glucopyranos-1-yl)-benzene L-proline monohydrate.
Claims (2)
1. An intermediate compound selected from the group consisting of:
2. The intermediate compound of claim 1 , wherein the intermediate compound is:
Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jan 18, 2022
From: WANG, XIAO-JUN; SAHLI, STEFAN; WEBER, BEAT THEODOR; BRINK, MONIKA; SHU, CHUTIAN; YANG, BING-SHIOU
To: BOEHRINGER INGELHEIM VETMEDICA GMBH
Reel/Frame 058676/0684 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jan 18, 2022
From: HIMMELSBACH, FRANK; ECKHARDT, MATTHIAS
To: BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG
Reel/Frame 058678/0139 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jan 18, 2022
From: BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG
To: BOEHRINGER INGELHEIM VETMEDICA GMBH
Reel/Frame 058678/0214 →
Priority Claims (1)
EP 17208315
· Dec 19, 2017
· regional
Continuity (2)
Division
16771717
Cited By (1)