IP Library Granted Patent US 12,043,840
Granted Patent B2
US 12,043,840 · App. 17/538,322 · Granted Jul 23, 2024

3'UTR sequence for transgene expression

Inventors: Lyudmila Sidorenko (Johnston, IA); Cory M. Larsen (Zionsville, IN); Geny Anthony (Urbandale, IA); Shreedharan Sriram (Waukee, IA); Holly Jean Butler (Indianapolis, IN); Lynne E. Sims (Polk City, IA); Scott H. Diehn (Altoona, IA); Gilda M. Rauscher (Johnston, IA); Kevin G. Ripp (Johnston, IA); Knut Meyer (Colona, IL)
C12N15/8223C12N15/8216Y02A40/146
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Quick Facts
Patent No.
US 12,043,840
App. No.
17/538,322
Granted
Jul 23, 2024
Kind
B2
Abstract

This disclosure concerns compositions and methods for promoting transcription of a nucleotide sequence in a plant or plant cell, employing a promoter from a GmCAB2 gene. Some embodiments relate to a promoter or a 5′ UTR from a GmCAB2 gene that functions in plants to promote transcription of operably linked nucleotide sequences. Other embodiments relate to a 3′ UTR or a terminator from a GmCAB2 gene that functions in plants to promote transcription of operably linked nucleotide sequences.

Claims (8)

1. A nucleic acid vector comprising a 3′ UTR operably linked to: a) a heterologous polylinker sequence; or b) a non-GmCAB2 polynucleotide sequence, wherein said 3′ UTR consists of a polynucleotide sequence that has at least 97% sequence identity with SEQ ID NO:5.

2. The nucleic acid vector of claim 1 , wherein said 3′ UTR is 425 bp in length.

3. The nucleic acid vector of claim 1 , further comprising a sequence encoding a selectable maker.

4. The nucleic acid vector of claim 1 , wherein said non-GmCAB2 polynucleotide sequence is a transgene.

5. The nucleic acid vector of claim 4 , wherein the transgene encodes a selectable marker or a gene product conferring insecticidal resistance, herbicide tolerance, expression of an RNAi, nitrogen use efficiency, water use efficiency, or nutritional quality.

6. The nucleic acid vector of claim 1 , further comprising a promoter polynucleotide sequence of SEQ ID NO:2, wherein the promoter sequence is operably linked to said polylinker or said non-GmCAB2 polynucleotide sequence.

7. The nucleic acid vector of claim 6 , further comprising an intron sequence.

8. The nucleic acid vector of claim 6 , wherein said promoter has tissue preferred specific expression.

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 9, 2024
From: SIDORENKO, LYUDMILA; LARSEN, CORY M.; ANTHONY, GENY; SRIRAM, SHREEDHARAN; BUTLER, HOLLY JEAN
To: DOW AGROSCIENCES LLC
Reel/Frame 067042/0944 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 9, 2024
From: SIDORENKO, LYUDMILA; LARSEN, CORY M.; ANTHONY, GENY; SRIRAM, SHREEDHARAN; BUTLER, HOLLY JEAN
To: DOW AGROSCIENCES LLC
Reel/Frame 067045/0146 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 9, 2024
From: SIMS, LYNNE E.; DIEHN, SCOTT H.; RAUSCHER, GILDA M.; RIPP, KEVIN G.; MEYER, KNUT
To: PIONEER HI-BRED INTERNATIONAL, INC.
Reel/Frame 067045/0532 →
CHANGE OF NAME Recorded Apr 9, 2024
From: DOW AGROSCIENCES LLC
To: CORTEVA AGRISCIENCE LLC
Reel/Frame 067046/0250 →
Continuity (4)
Continuation 16758649
Provisional Application 62727007 · Sep 5, 2018
Provisional Application 62578658 · Oct 30, 2017
Related Publication 20220090111A1 · Mar 24, 2022
Cited By (1)
US 12,319,918