IP Library › Granted Patent US 12,329,635
Granted Patent B2
US 12,329,635 · App. 17/543,555 · Granted Jun 17, 2025

Flared prosthetic cardiac valve delivery devices and systems

Inventors: Ali Salahieh (Saratoga, CA); Connor G. Mulcahy (San Francisco, CA); Alice Yang (Campbell, CA); Savina Brachthauser Balcells (Los Gatos, CA); Mitchell Young (San Francisco, CA); Jonathan H. Oakden (San Jose, CA); Jasper Adamek-Bowers (San Francisco, CA); Cornelius Crowley (San Francisco, CA); Terrence Vick (Los Gatos, CA); Balvir Johal (San Jose, CA); Thu Hoang Pham (San Jose, CA)
Assignee: Shifamed Holdings, LLC
A61F2/2418A61F2220/0008A61F2220/0025A61F2230/005A61F2230/0078A61F2230/0091A61F2250/0039
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Quick Facts
Patent No.
US 12,329,635
App. No.
17/543,555
Granted
Jun 17, 2025
Kind
B2
Abstract

A device for treating a diseased native valve in a patient is provided, the device including a frame structure; a valve segment positioned radially within the frame structure, the valve segment comprising a plurality of leaflets, and a plurality of commissure attachment mechanisms coupling the leaflets to the frame structure, each commissure attachment mechanism extending radially inwards from an outflow end of the frame structure as to create a gap between an interior diameter of the outflow end and an outflow edge of the valve segment. Other embodiments and methods of use are also provided.

Claims (31)

1. A device for treating a diseased native valve in a patient, the device comprising:

a frame structure comprising an inflow portion, a central annular portion having a first circular cross-section with a first inner diameter, and a flared outflow portion that has a second circular cross-section with a second inner diameter larger than the first inner diameter of the central annular portion;

a valve segment positioned radially within the frame structure and extending from the central annular portion to the flared outflow portion, the valve segment comprising a plurality of leaflets; and

a plurality of commissure attachment mechanisms coupling the plurality of leaflets to the frame structure, each commissure attachment mechanism extending radially and bending inwards approximately 180 degrees from an outflow end of the frame structure to align with the first inner diameter such that the plurality of leaflets form a cylindrical flow path from the central annular portion to the plurality of commissure attachment mechanisms for blood passing therethrough.

2. The device of claim 1 , wherein an inflow edge of the valve segment is unsupported by the frame structure.

3. The device of claim 2 , wherein the inflow edge is spaced radially inwards from an inflow end of the frame structure.

4. The device of claim 1 , wherein an inflow end of the frame structure is flared radially outwards.

5. The device of claim 1 , wherein tips of the outflow end point substantially axially.

6. The device of claim 1 , wherein the plurality of commissure attachment mechanisms each comprise a paddle, each of the paddles including a slot therein through which tabs of the plurality of leaflets pass.

7. The device of claim 6 , wherein the paddle further comprises a plurality of holes therethrough for sewing attachment of the tabs to the paddle.

8. The device of claim 1 , wherein the plurality of commissure attachment mechanisms each include a post that attaches to the outflow end of the frame structure and curves radially inwards.

9. The device of claim 8 , wherein the post attaches to a strut of the outflow end, and wherein a thickness of the post is greater than a thickness of the strut.

10. The device of claim 1 , wherein the gap is between 1.5 mm and 4 mm when the plurality of leaflets are fully opened.

11. The device of claim 1 , wherein the plurality of leaflets are unsupported except at the commissure attachment mechanisms.

12. The device of claim 1 , further comprising a spiral anchor configured to be placed around the central annular portion of the frame structure.

13. The device of claim 12 , wherein the frame structure comprises a plurality of struts, and wherein the struts are configured to create an area of flexibility within the central annular portion of the frame structure.

14. The device of claim 1 , wherein each commissure attachment mechanism is integrally formed with the frame structure.

15. The device of claim 1 , wherein the plurality of commissure attachment mechanisms extend radially inwards to point towards an inflow direction of the frame structure, wherein the outflow end of the frame structure further comprises a plurality of tips that point towards an outflow direction of the frame structure.

16. The device of claim 1 , wherein the plurality of commissure attachment mechanisms comprises up to three commissure attachment mechanisms.

17. The device of claim 1 , wherein commissures of the plurality of leaflets are directly attached to the plurality of commissure attachment mechanisms.

18. A device for treating a diseased native valve in a patient, the device comprising:

a frame structure comprising a central annular portion having a first circular cross-section with a first inner circumference, an inflow portion, and an outflow portion, wherein the outflow portion is flared radially outwards relative to the central annular portion such that it has a second circular cross-section with a second inner circumference that is larger than the first inner circumference;

a valve segment positioned radially within the frame structure, the valve segment comprising a plurality of leaflets; and

a plurality of commissure attachment mechanisms coupling the plurality of leaflets to the outflow portion of the frame structure, each commissure attachment mechanism extending radially inwards such that a third inner circumference formed by the commissure attachment mechanisms is equal to the first inner circumference of the central annular portion.

19. The device of claim 18 , wherein an inflow edge of the valve segment is unsupported by the frame structure.

20. The device of claim 19 , wherein the inflow edge is spaced radially inwards from the inflow portion of the frame structure.

21. The device of claim 18 , wherein the inflow portion of the frame structure is flared radially outwards.

22. The device of claim 18 , wherein the outflow portion further comprises tips that point substantially axially in an outflow direction of the frame structure.

23. The device of claim 22 , wherein the plurality of commissure attachment mechanisms further comprise second tips that point substantially axially in an inflow direction of the frame structure.

24. The device of claim 18 , wherein the plurality of commissure attachment mechanisms comprises up to three commissure attachment mechanisms.

25. The device of claim 18 , wherein commissures of the plurality of leaflets are directly attached to the plurality of commissure attachment mechanisms.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 29, 2025
From: SHIFAMED HOLDINGS, LLC
To: TIOGA CARDIOVASCULAR, INC.
Reel/Frame 073425/0381 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 12, 2023
From: SALAHIEH, ALI; MULCAHY, CONNOR G.; YANG, ALICE; BALCELLS, SAVINA BRACHTHAUSER; YOUNG, MITCHELL; OAKDEN, JONATHAN H.; ADAMEK-BOWERS, JASPER; CROWLEY, CORNELIUS; VICK, TERRENCE; JOHAL, BALVIR; PHAM, THU HOANG
To: SHIFAMED HOLDINGS, LLC
Reel/Frame 063307/0507 →
Continuity (4)
Provisional Application 63274821 · Nov 2, 2021
Provisional Application 63173281 · Apr 9, 2021
Provisional Application 63121812 · Dec 4, 2020
Related Publication 20220175522A1 · Jun 9, 2022
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