Skin care compositions and methods for regulating sebum production

1. A composition intended for application onto oily-prone skin, the composition comprising:

(1) a mixture of at least:

(a) about 0.02 to about 1% by weight of an extract capable of activating a cannabinoid type-2 receptor selected from Cannabis, Echinacea , Rue, members of the plant genus Brassica , and a Pogostemon Cablin leaf;

(b) about 0.1 to about 3% by weight of a blend of Tetraselmis chuii and Fucus spiralis algae extracts; and

(c) about 0.1 to about 4% by weight of an extract of Centella asiatica;

wherein all weights are based on total weight of the composition;

(2) optionally, an emulsifier; and

(3) a dermatologically acceptable carrier,

wherein the composition has a pH ranging from about 4.5 to about 5.5.

2. The composition of claim 1 , wherein (a) is employed in an amount of from about 0.02 to about 0.05% by weight, based on the total weight of the composition.

3. The composition of claim 1 , wherein (a) is employed in an amount of from about 0.02 to about 0.03% by weight, based on the total weight of the composition.

4. The composition of claim 1 , wherein (b) is employed in an amount of from about 0.5 to about 2.5% by weight, based on the total weight of the composition.

5. The composition of claim 1 , wherein (b) is employed in an amount of from about 1.0 to about 2.0% by weight, based on the total weight of the composition.

6. The composition of claim 1 , wherein (c) is employed in an amount of from about 1.0 to about 3.0% by weight, based on the total weight of the composition.

7. The composition of claim 1 , wherein (c) is employed in an amount of from about 1.5 to about 2.5% by weight, based on the total weight of the composition.

8. The composition of claim 1 , further comprising from about 0.1 to about 10% by weight, based on the total weight of the composition, of at least one auxiliary active ingredient selected from Betula alba extract, a glycolipid, Bakuchiol, an anti-acne active ingredient, an antimicrobial peptide, a bacteriophage, a genetically engineered enzyme capable of degrading P. acnes biofilm, and combinations thereof.

9. The composition of claim 8 , wherein the at least one auxiliary active ingredient is selected from: an anti-acne active ingredient, a genetically engineered bacteriophage targeted for P. acnes , a genetically engineered bacteriophage targeted for S. epidermis , and combinations thereof.

10. The composition of claim 1 , wherein (a) comprises a phytocannabinoid-infused Pogostemon Cablin extract.

11. The composition of claim 1 , further comprising a preservative system that comprises:

(A) from about 1 to about 5% by weight, of a Lactobacillus ferment;

(B) from about 1 to about 5% by weight, of Lactobacillus and Cocos nucifera fruit extract;

(C) up to about 0.5% by weight of salicylic acid;

(D) up to about 0.5% by weight of at least one salt of a weak acid; and

(E) from about 1 to about 10% by weight of propanediol, all weights based on the total weight of the composition.

12. The composition of claim 1 , further comprising from about 0.01 to about 0.05% by weight of an extract of Tulsi.

13. The composition of claim 9 , wherein the anti-acne active ingredient is selected from salicylic acid, sulfur, a fruit acid, gluconolactone, and combination thereof.

14. The composition of claim 1 , wherein (a) is employed in an amount of from about 0.02 to about 0.05% by weight, (b) is employed in an amount of from about 0.5 to about 2.5% by weight, and (c) is employed in an amount of from about 1.0 to about 3.0% by weight.

15. A composition intended for application onto human skin in order to enhance its health and appearance, the composition comprising:

(1) a mixture of at least:

(a) from about 0.02 to about 0.03% by weight of a phytocannabinoid-infused Pogostemon Cablin extract;

(b) from about 1 to about 2% by weight of a blend of Tetraselmis chuii and Fucus spiralis algae extracts;

(c) from about 1.5 to about 2.5% by weight of Centella asiatica extract; and

(d) from about 0.02 to about 0.03% by weight of Tulsi extract;

(2) optionally, an emulsifier;

(3) a preservative system comprising:

(A) from about 2 to about 4% by weight, of a Lactobacillus ferment;

(B) from about 2 to about 4% by weight, of Lactobacillus and Cocos nucifera fruit extract;

(C) from about 0.25 to about 0.4% by weight, of salicylic acid;

(D) from about 0.2 to about 0.4% by weight of potassium sorbate; and

(E) from about 4 to about 6% by weight of propanediol,

wherein all weights are based on total weight of the composition;

(4) a dermatologically acceptable carrier; and

(5) optionally, at least one auxiliary ingredient selected from Betula alba extract, a glycolipid, Bakuchiol, an anti-acne active ingredient, an antimicrobial peptide, a bacteriophage, a genetically engineered enzyme capable of degrading P. acnes biofilm, and combinations thereof,

wherein the composition has a pH ranging from about 4.8 to about 5.3.

16. The composition of claim 15 , wherein the auxiliary ingredient is selected from: an anti-acne active ingredient, a genetically engineered bacteriophage targeted for P. acnes , a genetically engineered bacteriophage targeted for S. epidermis , and combinations thereof; optionally wherein the anti-acne ingredient is selected from salicylic acid, sulfur, a fruit acid, a gluconolactone, and combinations thereof.

17. A method of managing exaggerated sebum production in oily-prone skin, the method comprising applying onto the skin a composition that comprises:

(1) a mixture of at least:

(a) about 0.02 to about 1% by weight of an extract capable of activating a cannabinoid type-2 receptor selected from Cannabis, Echinacea , Rue, members of the plant genus Brassica , and a Pogostemon Cablin leaf;

(b) about 0.1 to about 3% by weight of a blend of Tetraselmis chuii and Fucus spiralis algae extracts; and

(c) about 0.1 to about 4% by weight of an extract of Centella asiatica;

wherein all weights are based on the total weight of the composition;

(2) optionally, an emulsifier; and

(3) a dermatologically acceptable carrier,

wherein the composition has a pH ranging from about 4.5 to about 5.5.

18. The method of claim 17 , wherein (a) is employed in an amount of from about 0.02 to about 0.03% by weight, based on the total weight of the composition.

19. The method of claim 17 , wherein (b) is employed in an amount of from about 1.0 to about 2.0% by weight, based on the total weight of the composition.

20. The method of claim 17 , wherein (c) is employed in an amount of from about 1.0 to about 3.0% by weight, based on the total weight of the composition.

21. The method of claim 17 , wherein the composition further comprises from about 0.1 to about 10% by weight, based on the total weight of the composition, of at least one auxiliary active ingredient selected from Betula alba extract, a glycolipid, Bakuchiol, an anti-acne active ingredient, an antimicrobial peptide, a bacteriophage, a genetically engineered enzyme capable of degrading P. acnes biofilm, and combinations thereof.

22. The method of claim 21 , wherein the at least one auxiliary active ingredient is selected from: an anti-acne active ingredient, a genetically engineered bacteriophage targeted for P. acnes , a genetically engineered bacteriophage targeted for S. epidermis , and combinations thereof.

23. The method of claim 17 , wherein (a) comprises a phytocannabinoid-infused Pogostemon Cablin extract.

24. The method of claim 17 , wherein the composition further comprises a preservative system that comprises:

(A) from about 1 to about 5% by weight, of a Lactobacillus ferment;

(B) from about 1 to about 5% by weight, of Lactobacillus and Cocos nucifera fruit extract;

(C) up to about 0.5% by weight of salicylic acid;

(D) up to about 0.5% by weight of at least one salt of a weak acid; and

(E) from about 1 to about 10% by weight of propanediol, all weights based on the total weight of the composition.

25. A method of managing exaggerated sebum production in oily-prone skin, the method comprising applying onto the skin a composition that comprises:

(1) a mixture of at least:

(a) from about 0.02 to about 0.03% by weight of a phytocannabinoid-infused Pogostemon Cablin extract;

(b) from about 1 to about 2% by weight of a blend of Tetraselmis chuii and Fucus spiralis algae extracts;

(c) from about 1.5 to about 2.5% by weight of Centella asiatica extract; and

(d) from about 0.02 to about 0.03% by weight of Tulsi extract;

(2) optionally, an emulsifier;

(3) a preservative system comprising:

(A) from about 2 to about 4% by weight, of a Lactobacillus ferment;

(B) from about 2 to about 4% by weight, of Lactobacillus and Cocos nucifera fruit extract;

(C) from about 0.25 to about 0.4% by weight, of salicylic acid;

(D) from about 0.2 to about 0.4% by weight of potassium sorbate; and

(E) from about 4 to about 6% by weight of propanediol,

wherein all weights are based on total weight of the composition;

(4) a dermatologically acceptable carrier; and

(5) optionally, at least one auxiliary ingredient selected from Betula alba extract, a glycolipid, Bakuchiol, an anti-acne active ingredient, an antimicrobial peptide, a bacteriophage, a genetically engineered enzyme capable of degrading P. acnes biofilm, and combinations thereof,

wherein the composition has a pH ranging from about 4.5 to about 5.5.

26. The method of claim 25 , wherein the auxiliary ingredient is selected from: an anti-acne active ingredient, a genetically engineered bacteriophage targeted for P. acnes , a genetically engineered bacteriophage targeted for S. epidermis , and combinations thereof; optionally wherein the anti-acne ingredient is selected from salicylic acid, sulfur, a fruit acid, gluconolactone, and combinations thereof.

27. The method of claim 17 , wherein the mixture of (1) further comprises from about 0.01 to about 0.05% by weight of an extract of Tulsi.

28. The method of claim 22 , wherein the anti-acne active ingredient is selected from salicylic acid, sulfur, a fruit acid, gluconolactone, and combinations thereof.

29. The method of claim 17 , wherein (a) is employed in an amount of from about 0.02 to about 0.05% by weight, (b) is employed in an amount of from about 0.5 to about 2.5% by weight, and (c) is employed in an amount of from about 1.0 to about 3.0% by weight.