Optimizing analyte sensor calibration

1. A continuous glucose monitoring system, comprising:

a transcutaneous glucose sensor having an in vivo portion configured to be positioned in contact with an interstitial fluid of a user;

a data processing unit couplable to the transcutaneous glucose sensor and including

a data processing unit non-transitory memory, and

at least one data processing unit processor coupled to the data processing unit non-transitory memory; and

a receiver commutatively coupled to the data processing unit via a communication link and including

a receiver non-transitory memory,

at least one receiver processor coupled to the receiver non-transitory memory, and

an output device;

wherein at least one of the at least one data processing unit processor and the at least one receiver processor is configured to store a calibration schedule in the respective non-transitory memory, wherein the calibration schedule comprises a plurality of scheduled calibration events for receiving scheduled blood glucose measurements to calibrate the glucose sensor;

upon receiving an unscheduled blood glucose measurement after a successful prior scheduled calibration event, but before a next scheduled calibration event, at least one of the at least one data processing unit processor and the at least one receiver processor is configured to provide a prompt, via the output device, to verify the unscheduled blood glucose measurement;

upon receiving, via the output device, a confirmation acknowledgment to the prompt to verify the unscheduled blood glucose measurement, at least one of the at least one data processing unit processor and the at least one receiver processor is configured to perform an unscheduled calibration event using the unscheduled blood glucose measurement to calibrate the glucose sensor using the unscheduled blood glucose measurement;

at least one of the at least one data processing unit processor and the at least one receiver processor is configured to determine if the unscheduled calibration event successfully calibrated the glucose sensor;

at least one of the at least one data processing unit processor and the at least one receiver processor is configured to provide a notification, via the output device, if the unscheduled calibration event failed; and

at least one of the at least one data processing unit processor and the at least one receiver processor is configured to update the calibration schedule to override or modify the next scheduled calibration event if the unscheduled calibration event was successful.

2. The system of claim 1 , wherein to update the calibration schedule, at least one of the at least one data processing unit processor and the at least one receiver processor is further configured to modify the next scheduled calibration event to be a fixed time period after the unscheduled calibration event.

3. The system of claim 2 , wherein the fixed time period is the same as a time period between the successful prior scheduled calibration event and the next scheduled calibration event before modification of the next calibration event.

4. The system of claim 1 , wherein to perform the unscheduled calibration event, at least one of the at least one data processing unit processor and the at least one receiver processor is further configured to validate a calibration condition parameter associated with the calibration of the glucose sensor.

5. The system of claim 4 , wherein to validate the calibration condition parameter associated with the calibration of the glucose sensor, at least one of the at least one data processing unit processor and the at least one receiver processor is further configured to determine if the unscheduled blood glucose measurement is within an acceptable range.

6. The system of claim 4 , wherein the calibration condition parameter comprises a glucose rate of change.

7. The system of claim 1 , wherein the calibration schedule comprises a first predetermined calibration event scheduled 12 hours after a prior scheduled calibration event.

8. The system of claim 7 , wherein the calibration schedule comprises a second predetermined calibration event scheduled 12 hours after the first scheduled predetermined calibration event.

9. The system of claim 8 , wherein the calibration schedule comprises a third predetermined calibration event scheduled 24 hours after the second scheduled predetermined calibration event.

10. The system of claim 9 , wherein the calibration schedule comprises additional predetermined calibration events scheduled every 24 hours after the third scheduled predetermined calibration event.

11. The system of claim 7 , wherein upon receiving the unscheduled blood glucose measurement after the first predetermined calibration event and before the second predetermined calibration event, at least one of the at least one data processing unit processor and the at least one receiver processor is further configured to update the calibration schedule by modifying the second predetermined calibration event to be scheduled 12 hours after the unscheduled calibration event.

12. The system of claim 8 , wherein upon receiving the unscheduled blood glucose measurement after the first predetermined calibration event and before the second predetermined calibration event, at least one of the at least one data processing unit processor and the at least one receiver processor is further configured to update the calibration schedule by modifying the second predetermined calibration event to be scheduled 12 hours after the unscheduled calibration event and the third predetermined calibration event to be scheduled 24 hours after the modified second predetermined calibration event.

13. The system of claim 9 , wherein upon receiving the unscheduled blood glucose measurement after the first predetermined calibration event and before the second predetermined calibration event, at least one of the at least one data processing unit processor and the at least one receiver processor is further configured to update the calibration schedule by modifying the second predetermined calibration event to be scheduled 12 hours after the unscheduled calibration event, the third predetermined calibration event to be scheduled 24 hours after the modified second predetermined calibration event, and the additional predetermined calibration events to be scheduled every 24 hours after the modified third scheduled predetermined calibration event.

14. The system of claim 9 , wherein upon receiving the unscheduled blood glucose measurement after the second predetermined calibration event and before the third predetermined calibration event, at least one of the at least one data processing unit processor and the at least one receiver processor is further configured to update the calibration schedule by modifying the third predetermined calibration event to be scheduled 24 hours after the unscheduled calibration event.

15. The system of claim 10 , wherein upon receiving the unscheduled blood glucose measurement after the second predetermined calibration event and before the third predetermined calibration event, at least one of the at least one data processing unit processor and the at least one receiver processor is further configured to update the calibration schedule by modifying the third predetermined calibration event to be scheduled 24 hours after the unscheduled calibration event and the additional predetermined calibration events to be scheduled every 24 hours after the modified third scheduled predetermined calibration event.

16. The system of claim 1 , wherein the calibration schedule comprises a first predetermined calibration event scheduled 24 hours after a prior scheduled calibration event.

17. The system of claim 16 , wherein the calibration schedule comprises a second predetermined calibration event scheduled 24 hours after the first scheduled predetermined calibration event.

18. The system of claim 17 , wherein the calibration schedule comprises additional predetermined calibration events scheduled every 24 hours after the second scheduled predetermined calibration event.

19. The system of claim 17 , wherein upon receiving the unscheduled blood glucose measurement after the first predetermined calibration event and before the second predetermined calibration event, at least one of the at least one data processing unit processor and the at least one receiver processor is further configured to update the calibration schedule by modifying the second predetermined calibration event to be scheduled 24 hours after the unscheduled calibration event.

20. The system of claim 18 , wherein upon receiving the unscheduled blood glucose measurement after the first predetermined calibration event and before the second predetermined calibration event, at least one of the at least one data processing unit processor and the at least one receiver processor is further configured to update the calibration schedule by modifying the second predetermined calibration event to be scheduled 24 hours after the unscheduled calibration event and the additional predetermined calibration events to be scheduled every 24 hours after the modified second scheduled predetermined calibration event.

21. The system of claim 1 , wherein the calibration schedule comprises a plurality of different time periods between the plurality of scheduled calibration events.

22. The system of claim 1 , wherein at least one of the at least one data processing unit processor and the at least one receiver processor is further configured to determine a validity of glucose sensor data from the glucose sensor.

23. The system of claim 1 , wherein the unscheduled blood glucose measurement is determined via a blood glucose test strip.

24. The system of claim 1 , wherein to calibrate the glucose sensor using the unscheduled blood glucose measurement, at least one of the at least one data processing unit processor and the at least one receiver processor is further configured to:

change a parameter associated with the glucose sensor based on the unscheduled blood glucose measurement.

25. One or more computer-readable non-transitory storage media embodying software that is operable when executed to:

store a calibration schedule in the non-transitory memory, wherein the calibration schedule comprises a plurality of scheduled calibration events for receiving scheduled blood glucose measurements to calibrate a glucose sensor;

upon receiving an unscheduled blood glucose measurement after a successful prior scheduled calibration event but before a next scheduled calibration event, provide a prompt, via an output device, to verify the unscheduled blood glucose measurement;

upon receiving, via the output device, a confirmation acknowledgment to the prompt to verify the unscheduled blood glucose measurement, perform an unscheduled calibration event using the unscheduled blood glucose measurement to calibrate the glucose sensor using the unscheduled blood glucose measurement;

determine if the unscheduled calibration event successfully calibrated the glucose sensor;

provide, via the output device, a notification if the unscheduled calibration event failed; and

update the calibration schedule to override or modify the next scheduled calibration event if the unscheduled calibration event was successful.

26. The media of claim 25 , wherein the updating the calibration schedule further comprises modifying the next scheduled calibration event to be a fixed time period after the unscheduled calibration event.

27. The media of claim 26 , wherein the fixed time period is the same as a time period between the successful prior scheduled calibration event and the next scheduled calibration event before modification.

28. The media of claim 27 , wherein performing the unscheduled calibration event further comprises validating a calibration condition parameter associated with the calibration of the glucose sensor.

29. The media of claim 28 , wherein the validating further comprises determining if the unscheduled blood glucose measurement is within an acceptable range.

30. The media of claim 28 , wherein the calibration condition parameter comprises a glucose rate of change.